Effect of oral clonidine on perioperative haemodynamic response and post-operative requirement of analgesic for patients undergoing laparoscopic surgery

Pandya, Dimple K; Patel, Tirth; Patel, Krupal; Sharma, Manisha; Batavia, Karan A

doi:10.33545/26643766.2021.v4.i2a.228

Cited by 1 publication

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“…[ 7 ] Intraoperative stress response can be reduced by using α-2 receptor stimuli. [ 8 9 10 ] The use of narcotics to control postoperative pain has many side effects, including respiratory weakness, drowsiness and sedation, postoperative nausea, and vomiting. Nonsteroidal anti-inflammatory drugs are also used to control postoperative pain in practice but they are associated with side effects, such as coagulation disorders, renal dysfunction, and gastrointestinal bleeding.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effect of Preoperative Oral Tizanidine and Pregabalin on Shoulder Pain in Laparoscopic Cholecystectomy Under General Anesthesia

Sane

Sayyadi

Abbasivash

et al. 2023

Advanced Biomedical Research

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Background: Shoulder pain is considered as the most important and relatively common postoperative cholecystectomy complications that often controls in recovery room by systemic narcotics that may have some side effects. The aim of this study was to evaluate the effect of premedication with oral tizanidine on shoulder pain relief after elective laparoscopic cholecystectomy. Materials and Methods: In this double-blinded clinical trial, 75 adults of American Society of Anesthesiologist physiologic state 1 and 2 scheduled for elective laparoscopic cholecystectomy under general anesthesia were selected and randomly divided in three groups of T, P, and control groups. Ninety minutes before the induction of anesthesia, patients received either 4 mg tizanidine (T group), 100 mg pregabalin (P group), or orally in 50cc or the same volume of plain water as a placebo (control group). Then, the vital signs, pain intensity, and the need for analgesic were measured during 24 hours and then compared in the groups. Results: There was no significant difference in patient characteristics, with respect to age, weight, gender, and duration of anesthesia and surgery between the groups ( P > 0.05). The pain intensity and need for analgesic were significantly lower in tizanidine and pregabalin groups than the control group ( P < 0.003) vs ( P < 0.001). There was no significant difference in vital signs characteristics between the groups. Conclusion: Oral administration of 4 mg tizanidine and 100 mg pregabalin 90 minutes before laparoscopic cholecystectomy significantly relive postoperative shoulder pain and analgesic consumption without any complication.

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Section: Introductionmentioning

confidence: 99%