Effect of oral contraceptive containing ethinyl estradiol combined with drospirenone vs. desogestrel on clinical and biochemical parameters in patients with polycystic ovary syndrome

Kriplani, Alka; Periyasamy, Anurekha Janaki; Agarwal, Nutan; Kulshrestha, Vidushi; Kumar, Anand; Ammini, Ariachery C.

doi:10.1016/j.contraception.2010.02.009

Cited by 95 publications

(84 citation statements)

References 27 publications

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“…The possible metabolic side effects of oral contraceptives are debated. In meta-analyses, treatment with oral contraceptives was associated with unchanged fasting insulin in PCOS (62), but fasting insulin is only a rough measure of insulin resistance (13) and different generation oral contraceptives could have divergent effects on metabolic risk (63). One year´s treatment with a third-generation oral contraceptive was associated with a median weight gain of 1.2 kg, which was evenly distributed on the upper and lower body regions and was unassociated with changes in testosterone levels (64).…”

Section: Cardiometabolic Disease In Pcosmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is the most prevalent endocrine condition in premenopausal women. The syndrome is characterized by hyperandrogenism, irregular menses and polycystic ovaries when other etiologies are excluded. Obesity, insulin resistance and low vitamin D levels are present in more than 50% patients with PCOS, these factors along with hyperandrogenism could have adverse effects on long-term health. Hyperinflammation and impaired epithelial function were reported to a larger extent in women with PCOS and could particularly be associated with hyperandrogenism, obesity and insulin resistance. Available data from register-based and data linkage studies support that metabolic-vascular and thyroid diseases, asthma, migraine, depression and cancer are diagnosed more frequently in PCOS, whereas fracture risk is decreased. Drug prescriptions are significantly more common in PCOS than controls within all diagnose categories including antibiotics. The causal relationship between PCOS and autoimmune disease represents an interesting new area of research. PCOS is a lifelong condition and long-term morbidity could be worsened by obesity, sedentary way of life, Western-style diet and smoking, whereas lifestyle intervention including weight loss may partly or fully resolve the symptoms of PCOS and could improve the long-term prognosis. In this review, the possible implications of increased morbidity for the clinical and biochemical evaluation of patients with PCOS at diagnosis and follow-up is further discussed along with possible modifying effects of medical treatment.

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Section: Cardiometabolic Disease In Pcosmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Morbidity in polycystic ovary syndrome

Glintborg

Andersen

2017

European Journal of Endocrinology

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“…34,35 The tool evaluates 6 elements in each study: the sequence generation, allocation concealment, blinding of participants, personnel and outcome assessors, completeness of follow up, selective outcome reporting, and presence of other biases. Each domain was assigned a score: "low risk, " or "high risk" or "unclear risk."…”

Section: Assessment Of Risk Of Bias and Quality Of The Evidence In Inmentioning

confidence: 99%

Metformin or Oral Contraceptives for Adolescents With Polycystic Ovarian Syndrome: A Meta-analysis

et al. 2016

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“…6 To date, contraceptive studies involving women with PCOS have focused mainly on efficacy, evaluating the effect of combined oral contraceptives on the reduction of hirsutism and hyperandrogenism. 7,8 Two studies assessed the metabolic effects of combined oral contraceptives in PCOS, but these studies had small sample sizes and could not evaluate for cardiovascular events. 9,10 Although women with PCOS have an increase in both cardiovascular risk factors and subclinical cardiovascular disease, 11 recent guidelines have concluded there are no data in the literature assessing the association between the use of oral contraceptives and cardiovascular disease among women with PCOS.…”

mentioning

confidence: 99%