Effect of oral gabapentin on postoperative epidural analgesia

Abstract

Oral gabapentin (1.2 g day(-1)) as an adjunct to epidural analgesia decreased pain and analgesic consumption. Despite an increased incidence of dizziness it also increased patient satisfaction.

Evaluation of the effect of gabapentin on postoperative analgesia with epidural morphine after abdominal hysterectomy

“…However, our study has shown that gabapentin when given preoperatively has resulted in significant less morphine consumption. The findings are consistent with the studies 4,25,30 in which gabapentin was used in the dose of 1200mg, the same dose as used in our study. Pandey et al 29 and Giron et al 31 in their study reported a higher incidence of sedation in patients who received gabapentin.…”

“…Alparslan et al 25 investigated, in a randomized, placebo-controlled, double-blind study, the efficacy and safety of gabapentin on pain after abdominal hysterectomy and on tramadol consumption. The VAS scores in the sitting and supine position at 1,4,8,12,16, and 20h were significantly lower in the gabapentin group when compared with the placebo group upto 20h after surgery. Fassoulaki et al 28 , in contrast, were unable to demonstrate a decrease in analgesic consumption and VAS scores at rest and after movement during the first 24h postoperatively in mastectomy surgery.…”

“…The use of lower dose of gabapentin may have been responsible for lesser side effects in our study. In another study Turan et al 4 evaluated the perioperative use of Gabapentin as a non-opioid analgesic adjuvant for postoperative pain management with patient-controlled epidural analgesia. When gabapentin 1.2g was given 1h before and for 2 days after surgery the VRS pain scores were significantly lower at 1, 4, 8, 12, and 16h postoperatively in patients receiving gabapentin than in those receiving placebo.…”

“…[4][5][6][7][8] Postoperative pains are not purely nociceptive in nature, and may consist of inflammatory, neurogenic, and visceral components. 9 Opioid analgesics remain the primary pharmacologic therapy for moderate to severe postoperative pain.…”

Perioperative gabapentin as a component of multimodal analgesia for postoperative pain after total knee arthroplasty

“…Gabapentin has been used to treat postoperative acute and chronic pain following major lower limb surgery [7,[18][19][20][21]. However, a recent well-designed study found that the use of gabapentin cannot prevent acute postoperative pain following TKA, and it resulted in increased adverse reactions [12].…”