2005
DOI: 10.1007/s00268-005-7721-4
|View full text |Cite
|
Sign up to set email alerts
|

Effect of Oral Glutamine Administration on Bacterial Tanslocation, Endotoxemia, Liver and Ileal Morphology, and Apoptosis in Rats with Obstructive Jaundice

Abstract: Postoperative complications in patients with obstructive jaundice remain increased when associated with endotoxemia and the inflammatory response due to gut barrier failure. Administration of glutamine has been proposed to maintain the integrity of the gut mucosa and thus reduce bacterial translocation (BT), but the effects of this pretreatment on apoptosis and histologic morphology of various organs affected by BT in obstructive jaundice have not been studied. We therefore studied the effects of oral glutamin… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

3
32
1
4

Year Published

2006
2006
2013
2013

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 50 publications
(40 citation statements)
references
References 37 publications
3
32
1
4
Order By: Relevance
“…Another interesting study demonstrated that oral glutamine could prevent increases in gut apoptosis and gut permeability in rats with obstructive jaundice. 35 In this present study, we found that glutamine supplementation could inhibit apoptotic cell death in the gut and has the potential to reduce gut damage following TBI. Glutamine deprivation may activate caspase-3 as a mechanism directly eliciting intrinsic apoptosis in enterocytes, 36 and glutamine limitation has been shown to modulate apoptosis via the extrinsic (death receptor) pathway.…”
Section: Discussionmentioning
confidence: 49%
“…Another interesting study demonstrated that oral glutamine could prevent increases in gut apoptosis and gut permeability in rats with obstructive jaundice. 35 In this present study, we found that glutamine supplementation could inhibit apoptotic cell death in the gut and has the potential to reduce gut damage following TBI. Glutamine deprivation may activate caspase-3 as a mechanism directly eliciting intrinsic apoptosis in enterocytes, 36 and glutamine limitation has been shown to modulate apoptosis via the extrinsic (death receptor) pathway.…”
Section: Discussionmentioning
confidence: 49%
“…White et al (26) detected a significant reduction only in liver tissue samples, whereas Karatepe et al (10) detected a significant reduction only in the blood. In some studies, a significant reduction in BT rates was observed in the MLNs and liver tissue samples in the groups supported with glutamine (7,9,18). On the other hand, in the study of Bildik et al (11) (11), in our study there was a significant reduction only in MLN samples in the group supported with glutamine, but no significant difference was detected, although there was a reduction of BT rates in the blood and other tissue samples.…”
contrasting
confidence: 64%
“…Two points play a key role in the pathophysiology of septic complications. One is physical disruption of the intestinal barrier function and the other is an impaired immune system, especially the reticuloendothelial system (RES) and metabolic functions of the liver because of cholestasis (1)(2)(3)(4)(5)(6)(7)(8)(9).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Roth et al (2002) reported that there is a significant correlation between the Gln supply and intracellular GSH content. The administration of Gln reduced liver injury after bile duct ligation in a model of obstructive jaundice (Margaritis et al 2005). In addition, preceding ingestion of a Gln suppressed liver injury in D-galactosamine-induced acute hepatitis (Komano et al 2008).…”
Section: Discussionmentioning
confidence: 99%