Effect of oral iron therapy on the symptoms of anaemia.

Elwood, Peter Creighton; Wood, Matthew R.

doi:10.1136/jech.20.4.172

Cited by 15 publications

(5 citation statements)

References 7 publications

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“…This postulate is strengthened by the fact that the symptom questionnaire could not differentiate iron replete subjects from those with depleted iron stores. Our findings are in accordance with an older placebo controlled study, in which neither any subjective differences in health complaints nor any subjective effects of iron therapy could be found between mildly anaemic and non-anaemic women (24,25). Recent well-designed studies using more sophisticated methods, have demonstrated statistically significant effects of iron therapy on some parameters of cognition, endurance and mood in adolescents, even in the absence of anaemia per definition (26)(27)(28)(29).…”

Section: Discussionsupporting

confidence: 91%

Anaemia and iron deficiency screening in adolescence: a pilot study of iron stores and haemoglobin response to iron treatment in a population of 14-15-year-olds in Norway

Eskeland

1999

Acta Paediatrica

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Screening for haemoglobin (Hb) and s-ferritin, in 176 of all 189 (93%) pupils at 8th grade (14-15-years-old) in one Norwegian community was performed in order to map the prevalence of anaemia and depleted iron stores. In order to determine the clinical significance of the findings, a questionnaire aimed at detecting symptoms or risk factors for iron deficiency was completed by all participants, and a 3 mo therapeutic trial with iron was offered to subjects with s-ferritin values below 15 microg/l. Four percent of girls and 8% of boys were anaemic according to WHO cut-off levels. S-ferritin <15 microg/l was found in 25% of girls and 30% of boys. Forty-four of 48 pupils with s-ferritin <15 microg/l completed the therapeutic trial. Only three pupils had a clinically significant increase in Hb, representing less than 2% of the population. The questionnaire gave no clues that could identify subjects with depleted iron stores. To increase Hb in one 14-15-y-old with depleted iron stores, 59 (95% CHI: 20-285) had to be screened and 16 (6-76) had to be given iron treatment. This pilot study suggests that functional iron deficiency is rare in Norwegian adolescents despite a high frequency of low iron stores. A double blind, placebo controlled study covering the entire span of pubescence is needed to confirm these results.

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Section: Discussionsupporting

confidence: 91%

Anaemia and iron deficiency screening in adolescence: a pilot study of iron stores and haemoglobin response to iron treatment in a population of 14-15-year-olds in Norway

Eskeland

1999

Acta Paediatrica

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“…Our study, however, appears to us to give very little encouragement for community health screening for anaemia. Though a fairly high proportion of women were detected with haemoglobin levels below commonly accepted lower limits of normal, thus being consistent with data obtained in the community surveys of Kilpatrick (1961), Elwood (1964), and others, yet the importance of " anaemia," so defined, appears to be relatively small. This assessment of importance is based both on the apparent absence of serious treatable underlying conditions in the subjects with the lowest haemoglobin levels and on the absence of unequivocal benefit in the symptoms of those treated with iron.…”

Section: Resultssupporting

confidence: 85%

Evaluation of a screening survey for anaemia in adult non-pregnant women.

Elwood¹,

Waters²,

Greene³

et al. 1967

BMJ

Self Cite

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Regional Ileitis-Feldman et al. and the central problem of whether primary psychosomatic disease exists. Nevertheless the significant emotional factors relating to psychosomatic illness noted in the literature were investigated and found not to apply to any important degree. We do, therefore, raise the question whether the disease should be regarded as psychosomatic in any way.BIBLIOGRAPHY Acheson, E. D. (1960). Gut, 1, 291. (1965). Chapter 11 in Badenocb and Brooke (1965). and Nefzger, M. D (1963). Gastroenrerology, 44, 7. Arieti, S (1959). American Hanabook of Psychiatry. New York.Armitage, G., and Wilson, M. (1950) Brit. 7. Surg., 38, 182. Atwell, J. D., Duthie, H. L., and Goligher, J. C. (1965). Ibid., 52, 966. Aylett, S. 0. (1966). Brit. med. 7., 1, 1001. Badenoch. J., and Brooke, B. N. (1965). Recent Advances in Gastroenterology. Boston.Bahn, A. K., Gardner. E. A., Alltop, L., Knatterud, G. L., and Solomon, M. (1967). Amer. 7. publ. Hith, 56, 2033. Bargen, J A. (1955. Wis. med. 7., 54, 367. -(1966 Grace. W. J. (1953). Gastroenterology, 23, 542. Hendrix, T. (1964). Chapter 4 in Mellinkoff (1964). Hunt, T. (1965). Trans. med. Soc. Lond., 81, 87. Janowitz, H. D. (195). 7. Mt Sinai Hosp., 22, 223. Kaelbling, R., and Patterson, R. M. (1966 Brit. med. J'., 1967, 4,[714][715][716][717] Considerable interest has been shown recently in community health screening (Backett, 1960 ; Wilson, 1963 ;Acheson, 1963; Horne, Clark, and Patterson, 1967). The value of any healthscreening procedure depends both on the proportion of persons detected with the disease (or diseases) being sought, or with treatable associated conditions, and on the importance to life or health of these conditions. The number of affected persons detected is dependent both on the prevalence of the disease, or the conditions associated with it, in the community to which screening is offered, and on the nature and extent of selection, if any, of those members of that community who co-operate. In fact very little is known about the selection of persons who readily co-operate in health-screening procedures except in a very few situations, such as mass miniature radiography (Bradbury, 1948) and cervical cytology (Wakefield and Bari6, 1965), in both of which it seems that affected individuals are, on average, less likely to co-operate than those who are unaffected, though in coal-workers' pneumoconiosis (Cochrane, 1951) and possibly in other compensatable industrial diseases the reverse is probably true. Other than in a few such cases very little is known about how persons who spontaneously attend community screening clinics differ from other members of the community.Assessment of the importance of the conditions detected during a screening survey necessitates value judgements which are not easily made and which ideally should be based on data relating to changes in the subsequent mortality or morbidity in the community screened. In the haematological community study described here the initial survey was evaluated as an ad hoc health-scree...

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“…These markedly lower estimates of prevalence of anemia in females are similar to what was observed in Vietnam. Since treatment for Hb between 8-12 g/dl, anemia by WHO criteria, improves Hb but not symptoms in non-pregnant women, an unduly high cutoff value inappropriate for a community may exaggerate the prevalence of anemia in a community without any obvious benefit [10].…”

Section: Discussionmentioning

confidence: 99%

When is a South Indian Really Anemic?

Pasupula

Reddy

2013

Ind J Clin Biochem

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To determine the normal range of Hemoglobin and cutoff values in healthy adults of Southern India, blood samples were analyzed for parameters of RBC and iron metabolism in 177 male and 203 female medical students. The data were compared with the American white population (NHANES III) and the WHO criteria for detection of anemia. The mean values for hemoglobin and hematocrit in male students differed minimally from American white males. However, values for parameters of iron metabolism were lower except total iron binding capacity (TIBC) which was higher. In female students, hemoglobin, hematocrit and parameters of iron metabolism were lower than American white females, except TIBC which was higher. Lower 5th percentile cutoff point (Mean -1.645 SD) in males and females were 13.5 and 10 g/dl respectively. In conclusion, South Indian adult males have Hb values similar to American male adults, but South Indian females have considerably lower Hb levels than American females, raising the questions about appropriateness of WHO or US criteria for detection of anemia in Indian females.

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Effect of oral iron therapy on the symptoms of anaemia.

Cited by 15 publications

References 7 publications

Anaemia and iron deficiency screening in adolescence: a pilot study of iron stores and haemoglobin response to iron treatment in a population of 14-15-year-olds in Norway

Anaemia and iron deficiency screening in adolescence: a pilot study of iron stores and haemoglobin response to iron treatment in a population of 14-15-year-olds in Norway

Evaluation of a screening survey for anaemia in adult non-pregnant women.

When is a South Indian Really Anemic?

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