Effect of Oral Isotretinoin Treatment on Retinal Nerve Fiber Layer Thickness

Uçak, Haydar; Aykut, Veysel; Öztürk, Savaş; Çiçek, Demet; Erden, Ilker; Demir, Betül

doi:10.2310/7750.2013.13168

Cited by 16 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ucak et al published a trial in 2014, where they assessed possible toxic effects of the treatment with isotretinoin 0.5–2 mg/kg/day for 4–9 months on the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL), and the results showed a significant decrease in posttreatment lower temporal (TL) values [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis

Kapała

Lewandowska

Placek

et al. 2022

IJERPH

View full text Add to dashboard Cite

Isotretinoin (ISO) is an oral prescription-only retinoid, well known for its acne-treating effect. However, it affects a substantial number of human cell types, causing a broad spectrum of adverse effects. The purpose of this study is to establish the isotretinoin therapy adverse events among human clinical trials and their prevalence. Two authors (J.K., J.L.) systematically performed the literature review and assessment from December 2021–February 2022. Three databases (PubMed, ClinicalTrials, and Cochrane Library) were searched using the following terms: “isotretinoin acne vulgaris” for published studies in English from 1980–2021. Finally, 25 randomized controlled clinical trials (RCTs) and five open-label clinical trials provided 3274 acne vulgaris suffering patients. Isotretinoin therapy affects almost all of the systems in the human body, causing numerous adverse events. However, they mainly concern mild mucocutaneous conditions (severe cases are rare) and represent individual responses to a drug. In addition, all adverse events are reversible and can be avoided by specific preparations.

show abstract

Section: Discussionmentioning

confidence: 99%

Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis

Kapała

Lewandowska

Placek

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…[11] Dinc et al [12] reported cases of decreased RNFL thickness and bilateral optical disc atrophy related to isotretinoin administration for the treatment of acne vulgaris. Ucak et al [13] reported the possible toxic effects of isotretinoinon RNFL, especially in the temporal layer. In the study conducted by Kapti et al [14] It is reported that isotretinoin has no effect on RNFL thickness We did not find a statistically significant difference in RNFL thickness in our study.…”

Section: Discussionmentioning

confidence: 99%

Macular Ganglion Cell Layer Thickness In Patients Using Oral Isotretinoin

Kocamış

Acer

2017

JOS

View full text Add to dashboard Cite

Objective: Determining the effects on macular ganglion cell layer thickness in patients using isotretinoin by utilization of optical coherence tomography. Material and Methods:Sixty eyes of 30 patients using isotretinoin and 60 eyes of 30 control group patients in the same age range were included in this study. The average age of the patients using isotretinoin was; 21.2 ± 3.62 years, whereas the average age of the patients in the control group was 22.7 ± 3.7 years. The thickness of the macular ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL) and subfoveal macular thickness of all patients were measured with optical coherence tomography (OCT). Results:The macular ganglion cell layer thickness in the OCT of the patients using isotretinoin was measured as 61.6±4.6 µm, 62.4±4.4µm, for the right and left eye respectively, whereas the thickness in the control group was measured as 60.6±4.1µm, 61.2±4.9µm respectively. The retinal nerve fiber layer thickness in the OCT of the patients using isotretinoin was measured as 74.8±11.3µm, 76.2±12.3µm, for the right and left eye respectively, whereas the thickness in the control group was measured as 72.2±10.5µm, 74.1±1.9µm, respectively. Conclusions:No statistically significant difference was observed in the macular ganglion cell layer thickness, retinal nerve fiber layer thickness and macular thickness in terms of both the right and left eyes between the control group and patients using isotretinoin.

show abstract

“…Regarding OECD countries, Uçak et al (2014) examined the relationship between carbon dioxide (CO 2 ) emissions and gross domestic product (GDP) for 20 high-income countries over the period 1961-2004. Their results have shown that there is a positive relationship between GDP and CO 2 , except for Norway.…”

Section: Literature Reviewmentioning

confidence: 99%

The Link between Economic Growth, Air Pollution and Health Expenditure in the G7 Countries

Zeiri,

Bouzir,

Mbarek

et al. 2023

IJEEP

View full text Add to dashboard Cite

The objective of this paper is to study the effect of economic growth and pollution on health expenditure in G7 countries, during the 1990-2020. In order to obtain a reliable estimate, we adopt the partial least squares (PLS) regression method, which focuses on three explanatory indicators (GDP, CO2, MR) and health expenditure (HE), as a dependent variable. The obtained empirical results reveal several important elements. First, all the models are significant, with the exception of Canada. Then, all countries have verified the economic theory that GDP positively affects HE. Then, we observe negative effects of CO2 emissions on HE, except in Japan. Finally, France, Italy, the United States and the United Kingdom have negative effects of MR on HE.

show abstract

Effect of Oral Isotretinoin Treatment on Retinal Nerve Fiber Layer Thickness

Cited by 16 publications

References 25 publications

Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis

Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis

Macular Ganglion Cell Layer Thickness In Patients Using Oral Isotretinoin

The Link between Economic Growth, Air Pollution and Health Expenditure in the G7 Countries

Contact Info

Product

Resources

About