Effect of oral l-arginine supplementation on post-exercise blood pressure in hypertensive adults: A systematic review with meta-analysis of randomized double-blind, placebo-controlled studies

Porto, Andrey Alves; Gonzaga, Luana Almeida; Benjamim, Cicero Jonas R.; Garner, David M.; Adami, Fernando; Valenti, Vincenzo

doi:10.1016/j.scispo.2021.04.003

Cited by 4 publications

(4 citation statements)

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“…Many studies have found a close relationship between arginine and hypertension. In patients with hypertension, the levels of arginine were low (42), and arginine supplementation could lower blood pressure levels (43)(44)(45)(46). Arginine synthesizes nitric oxide by nitric oxide synthase, and nitric oxide plays a vital role as an intercellular messenger and neurotransmitter in the cardiovascular system and nervous system, including promoting vasodilation, inhibiting platelet aggregation, inhibiting smooth muscle cell proliferation and so on (47).…”

Section: Discussionmentioning

confidence: 99%

Causal association between blood metabolites and risk of hypertension: a Mendelian randomization study

Cheng,

Yun,

Fan

et al. 2024

Front. Cardiovasc. Med.

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BackgroundPrevious studies have indicated a strong link between blood metabolites and hypertension, however the causality of metabolites and hypertension is unknown.MethodsTwo-sample Mendelian randomization (MR) analysis was performed to assess the causal relationship between 486 blood metabolites and essential hypertension (EHT). Blood metabolite GWAS data was utilized as the exposure, with EHT GWAS data as the outcome. To further verify the results, another different source of EHT GWAS data was repeatedly analyzed. The major MR analytic approach used to determine causality was inverse variance weighted (IVW), with MR-Egger, Weighted Median, and MR-PRESSO models serving as supplements. We used the Cochran Q test to examine heterogeneity. Horizontal pleiotropy was examined using MR-Egger intercept and MR-PRESSO global test. The MR Steiger test confirmed the causal relationship between blood metabolites and EHT.ResultsIn this study, nine blood metabolites associated with EHT were preliminarily identified by MR analysis, including four known metabolites (N-acetylornithine, X-12510–2-aminooctanoic acid, creatine, hexadecanedioate) and five unknown metabolites. Then another source of EHT GWAS data was repeatedly analyzed for further verification, and two overlapped metabolites (N-acetylornithine, X-12510-2-aminooctanoic acid) were found. There was a negative correlation between N-acetylornithine and EHT (OR = 0.987, 95% CI = 0.980–0.993, P = 1.01 × 10−4), Cochran's Q test suggested there was no heterogeneity (Q = 31.7586, P = 0.1331), MR-Egger intercept and MR-PRESSO global test suggested there was no horizontal pleiotropy (P > 0.05), Leave-one-out analysis indicated that no single single-nucleotide polymorphism (SNP) had a significant effect on the results, and MR Steiger test confirmed that the direction of causality was correct (P < 0.001). There was a negative correlation between X-12510-2-aminooctanoic acid and EHT (OR = 0.982, 95% CI = 0.972–0.993, P = 0.0017), and there was no evidence of heterogeneity or pleiotropy in multiple sensitivity analyses.ConclusionThe study discovered some blood metabolites causally linked to EHT, which might lead to new understandings of the pathophysiology of hypertension.

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Section: Discussionmentioning

confidence: 99%

Causal association between blood metabolites and risk of hypertension: a Mendelian randomization study

Cheng,

Yun,

Fan

et al. 2024

Front. Cardiovasc. Med.

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“…The analysis of cardiovascular behavior during exercise and the recovery phase is a valuable instrument for forecasting risk and sudden cardiac death in situations that enforce physiological stress, such as physical exercise [11][12][13][14][15]. The measurement of heart rate (HR) and HR variability (HRV), which permits the study of cardiac autonomic modulation, is regarded as a practical and reliable method for analyzing the outcomes of cardiovascular system interventions in response to physical exercise [16][17][18][19][20][21]. Furthermore, BP analyses with these variables create an understanding of hemodynamic control and, consequently, a more accurate analysis of global cardiovascular function [12,21].…”

Section: Introductionmentioning

confidence: 99%

“…The measurement of heart rate (HR) and HR variability (HRV), which permits the study of cardiac autonomic modulation, is regarded as a practical and reliable method for analyzing the outcomes of cardiovascular system interventions in response to physical exercise [16][17][18][19][20][21]. Furthermore, BP analyses with these variables create an understanding of hemodynamic control and, consequently, a more accurate analysis of global cardiovascular function [12,21].…”

Section: Introductionmentioning

confidence: 99%

Influence of Fluid Ingestion on Heart Rate, Cardiac Autonomic Modulation and Blood Pressure in Response to Physical Exercise: A Systematic Review with Meta-Analysis and Meta-Regression

Porto,

Benjamim,

da Silva Sobrinho

et al. 2023

Nutrients

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A systematic review was undertaken to investigate the involvement of hydration in heart rate (HR), HR variability (HRV) and diastolic (DBP) and systolic (SBP) blood pressure in response to exercise. Data synthesis: The EMBASE, MEDLINE, Cochrane Library, CINAHL, LILACS and Web of Science databases were searched. In total, 977 studies were recognized, but only 36 were included after final screening (33 studies in meta-analysis). This study includes randomized controlled trials (RCTs) and non-RCTs with subjects > 18 years old. The hydration group consumed water or isotonic drinks, while the control group did not ingest liquids. For the hydration protocol (before, during and after exercise), the HR values during the exercise were lower compared to the controls (−6.20 bpm, 95%CI: −8.69; −3.71). In the subgroup analysis, “water ingested before and during exercise” showed lower increases in HR during exercise (−6.20, 95%CI: 11.70 to −0.71), as did “water was ingested only during exercise” (−6.12, 95%CI: −9.35 to −2.89). Water intake during exercise only revealed a trend of avoiding greater increases in HR during exercise (−4,60, 95%CI: −9.41 to 0.22), although these values were not significantly different (p = 0.06) from those of the control. “Isotonic intake during exercise” showed lower HRs than the control (−7.23 bpm, 95% CI: −11.68 to −2.79). The HRV values following the exercise were higher in the hydration protocol (SMD = 0.48, 95%CI: 0.30 to 0.67). The values of the SBP were higher than those of the controls (2.25 mmHg, 95%CI: 0.08 to 4.42). Conclusions: Hydration-attenuated exercise-induced increases in HR during exercise, improved autonomic recovery via the acceleration of cardiac vagal modulation in response to exercise and caused a modest increase in SBP values, but did not exert effects on DBP following exercise.

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Section: Discussionmentioning

confidence: 99%

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Effect of oral l-arginine supplementation on post-exercise blood pressure in hypertensive adults: A systematic review with meta-analysis of randomized double-blind, placebo-controlled studies

Cited by 4 publications

References 31 publications

Causal association between blood metabolites and risk of hypertension: a Mendelian randomization study

Causal association between blood metabolites and risk of hypertension: a Mendelian randomization study

Influence of Fluid Ingestion on Heart Rate, Cardiac Autonomic Modulation and Blood Pressure in Response to Physical Exercise: A Systematic Review with Meta-Analysis and Meta-Regression

Datasheet1.docx

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