Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats

Rühle, KH; Khullar, Madhu; Kashyap, Manoj Kumar; Pandhi, P; Uppal, R

doi:10.1097/00004872-200018070-00014

Cited by 52 publications

(23 citation statements)

References 22 publications

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“…First, the early and persistent reduction in PBMC [Mg 2ϩ ] i that accompanies ALDOST was attenuated by a Mg 2ϩ -supplemented diet and NAC but not by CCB. As we and others have previously reported, 10 14,20,21 and with mineralocorticoid administration in humans. 22 weeks.…”

Section: Discussionsupporting

confidence: 66%

“…10 have been reported in rodent and human platelets during chronic mineralocorticoid excess (inappropriate for dietary Na ϩ intake) and in rodent neutrophils in response to dietary Mg 2ϩ deficiency. 14,22,28 The proinflammatory phenotype seen with dietary Mg 2ϩ deficiency is prevented when such a diet is simultaneously made Ca 2ϩ -deficient. 23 A Mg 2ϩ -supplemented diet has been reported to attenuate endothelin-1 production by heart, aorta, and kidneys in rats receiving DOC/salt treatment.…”

Section: Discussionmentioning

confidence: 99%

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Aldosteronism and a Proinflammatory Vascular Phenotype

et al. 2005

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Aldosteronism and a Proinflammatory Vascular Phenotype

et al. 2005

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“…19,20 It has been demonstrated that magnesium supplementation attenuates blood pressure increases in various models of hypertension, including the stroke-prone spontaneously hypertensive rat, 21 angiotensin II-induced hypertension, 22 and mineralocorticoid salt hypertension. 3,23,24 Although the effects of magnesium on blood pressure seem to be more rapid and pronounced in disease states such as hypertension, 21 our data indicate that chronic magnesium deficiency also influences blood pressure in normotensive animals.…”

Section: Discussionmentioning

confidence: 66%

Dysregulation of Vascular TRPM7 and Annexin-1 Is Associated With Endothelial Dysfunction in Inherited Hypomagnesemia

et al. 2009

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Abstract-Inadequate magnesium intake and hypomagnesemia may contribute to chronic diseases, such as hypertension.The novel magnesium transporter TRPM7 is a critical regulator of magnesium homeostasis in vascular cells, but its role in pathophysiology is unclear. In a model of hypomagnesemia, we examined microvascular structure and function, TRPM7 expression, and vascular inflammatory status using inbred mice selected for normal-high intracellular magnesium levels or low intracellular magnesium levels (MgLs). Blood pressure was significantly increased in MgLs compared with normal-high intracellular magnesium levels. Pressurized myography of mesenteric resistance arteries showed that MgLs had significantly impaired endothelial function together with decreased plasma nitrate levels and endothelial NO synthase expression when compared with normal-high intracellular magnesium levels. Significant differences in vascular structure were also evident in both mesenteric arteries and aortas from MgLs. Aortas from MgLs had increased medial cross-sectional areas, whereas mesenteric arteries from MgLs had increased lumen diameters with increased medial cross-sectional areas, indicating outward hypertrophic remodeling. Expression of the magnesium transporter TRPM7 was significantly elevated in the vasculature of MgLs, whereas expression of a TRPM7 downstream target, the anti-inflammatory molecule annexin-1, was reduced. MgLs had increased expression of vascular cell adhesion molecule-1 and plasminogen activator inhibitor-1, indicating vascular inflammation. Taken together, these data demonstrate that the inherited magnesium status of MgLs and normal-high intracellular magnesium levels mice affects magnesium transporter expression, endothelial function, vascular structure, and inflammation. Our findings suggest a potential regulatory role for TRPM7 signaling in the maintenance of vascular integrity. Alterations in magnesium status and/or TRPM7 signaling may contribute to vascular injury in conditions associated with hypomagnesemia. Key Words: magnesium Ⅲ TRPM7 Ⅲ endothelial function Ⅲ remodeling Ⅲ hypertrophy M agnesium, the second most abundant intracellular cation, is involved in many physiological processes regulating cardiovascular function. Magnesium influences vascular tone, vascular smooth muscle cell growth, inflammation, ion channel activity, and the production of vasoactive agents. 1 Under normal physiological conditions, magnesium levels in serum are maintained within a narrow range (0.7 to 1.1 mmol/L), and whole body magnesium balance is tightly controlled by regulating gastrointestinal absorption and renal excretion. On the other hand, in pathological conditions, hypomagnesemia and decreased tissue content of magnesium have been reported in various chronic diseases, such as type 2 diabetes mellitus and hypertension. 2 Several studies demonstrated that, in various experimental models of hypertension, magnesium supplementation attenuates the increase in blood pressure and ameliorates vascular damage. 3,4 Epidemiolo...

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“…Sin embargo otros autores refi eren que se reducen las cifras de PA, y que también disminuyen la incidencia de ACV 77,78 . En el mismo sentido, junto a la ingesta de vitamina D, podrían reducir la PA y también la frecuencia cardíaca en pacientes año-sos 79 . Podríamos concluir, en cuanto a las sales de calcio, que para confi rmar un potencial efecto protector son necesarias más investigaciones, ya que la evidencia actual no es sufi ciente para recomendar su uso en el tratamiento de la hipertensión arterial.…”

Section: ¿Cómo Infl Uyen Los Otros Minerales Presentes En Las Aguas Nunclassified

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Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats

Abstract: Magnesium supplementation prevents blood pressure elevation in DOCA hypertensive rats. These effects are associated with inhibition of platelet calcium uptake and decreased intracellular free calcium concentration.

Cited by 52 publications

References 22 publications

Aldosteronism and a Proinflammatory Vascular Phenotype

Aldosteronism and a Proinflammatory Vascular Phenotype

Dysregulation of Vascular TRPM7 and Annexin-1 Is Associated With Endothelial Dysfunction in Inherited Hypomagnesemia

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