Effect of oral prednisone on the measurement ofplasma steroid concentrations by the competitive protein-binding radioassay

Efficacy and safety of alternate-day prednisolone compared to single daily cloprednol were evaluated over a six-week period in 11 children with severe asthma requiring in-residence medical supervision and long-term corticosteroid therapy. Clinical indices of efficacy, including daily pulmonary symptom scores, number of asthma attacks, asthma severity scores, and bronchodilator usage, all favored cloprednol. Afternoon pulmonary function tests (FEV1, FVC, and PEFR) were all significantly improved during the cloprednol period. Although plasma cortisol values remained within the broad range of normal during the cloprednol period, mean values were consistent with partial pituitary-adrenal suppression similar in degree to that observed 24 hours after administration of an alternate-day program of prednisolone therapy. The results of this trial showed cloprednol in single daily doses to be more effective than prednisolone in alternate doses for the treatment of children with severe asthma.

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Short‐Term Efficacy and Side Effects of Cloprednol in Children with Asthma

Ellis

Morris

Kiechel

et al. 1979

The Journal of Clinical Pharma

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RIA vs. CPB for prednisolone

Colburn

Buller

1975

Journal of Pharmacokinetics and Biopharmaceutics

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A graded dose assessment of the efficacy of beclomethasone dipropionate aerosol for severe chronic asthma

Toogood¹,

Lefcoe²,

Haines³

et al. 1977

Journal of Allergy and Clinical Immunology

183

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Effect of oral prednisone on the measurement ofplasma steroid concentrations by the competitive protein-binding radioassay

Cited by 6 publications

References 14 publications

Short‐Term Efficacy and Side Effects of Cloprednol in Children with Asthma

Short‐Term Efficacy and Side Effects of Cloprednol in Children with Asthma

RIA vs. CPB for prednisolone

A graded dose assessment of the efficacy of beclomethasone dipropionate aerosol for severe chronic asthma

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