Effect of oral supplementation with branched-chain amino acid granules in the early stage of cirrhosis

Estimation of protein intake using urinary urea nitrogen in patients with early-stage liver cirrhosis

“…Although some reports have been shown the effects and benefits of longterm nutrition therapy using supplementation with BCAA for patients with LC. BCAA has been reported to be helpful in preventing events related to cirrhosis [14][15][16][17], nutrition status [9,[18][19][20], leg cramps [10], and overall quality of life [11]. The role of BCAA needs to be studied further.…”

Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis

“…Several studies have described that long-term supplementation with branched-chain amino acids (BCAA) was given to patients with decompensated cirrhosis for the treatment of protein malnutrition, and this therapy improved or maintained nutritional status, as well as increased survival rates [23][24][25][26][27][28]. However, these results have not been verified in larger studies, partly because of the lack of a BCAA preparation suitable for long-term treatment.…”

Inhibitory effect of branched-chain amino acid granules on progression of compensated liver cirrhosis due to hepatitis C virus

“…They showed that the BCAA treatment increased serum albumin levels in patients with cirrhosis and with BTR < 4, whereas there was no appreciable elevation in serum albumin levels in patients with BTR ≥ 4. 11,12 The BTR has been reported to correlate well with Fischer's ratio, 15 and a BTR value of 4 corresponds to a Fischer's ratio of 2. 11 In the present study, nearly all patients had a baseline Fischer's ratio of 2 or greater, and the BTR value was maintained without any decrease during the study.…”

“…Several studies have shown an effect of BCAA in patients with compensated cirrhosis by investigating infl uence of the therapy on serum albumin levels, 11,12 but no studies have been performed to investigate the effect of BCAA on the entire disease state of liver cirrhosis. Therefore, we conducted a randomized controlled trial on the presumption that treatment with BCAA in patients with compensated cirrhosis might possibly delay disease progression.…”