Effect of oral vitamin D supplementation on glycemic control in patients with type 2 diabetes mellitus with coexisting hypovitaminosis D: A parellel group placebo controlled randomized controlled pilot study

Upreti, Vimal; Maitri, Vijay; Dhull, Pawan; Handa, A; Prakash, Manyu; Behl, Anil

doi:10.1016/j.dsx.2018.03.008

Cited by 44 publications

(47 citation statements)

References 20 publications

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“…Meanwhile, Talaei et al [33] showed a significant decrease in serum FPG, insulin, and HOMA-IR in patients with T2DM who received weekly oral 50,000 IU of Vitamin D3 for 2 months. In Addition, Upreti et al [34] stated that Vitamin D3 for 6 months at a dose of 60,000 IU every week for the first 6 weeks and then once every 4 weeks until completion of the study had a beneficial effect on FBG and HbA1C levels.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Different Regimens of Vitamin D3 on Glucose Homeostasis in Type 2 Diabetic Patients

Ali

Ghanem

Sharaki

et al. 2019

Asian J Pharm Clin Res

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Objective: Vitamin D has a role in the regulation of pancreatic β-cell function and insulin sensitivity. Accordingly, Vitamin D deficiency is considered to be a risk factor for the development of type 2 diabetes mellitus (T2DM) and its complications. Therefore, the aim of the study was to assess and compare the effect of different regimens of Vitamin D3 on glucose homeostasis in patients with T2DM. Methods: The study included 80 patients with T2DM taking oral antidiabetic drugs. The patients were randomized to receive antidiabetic drugs alone or with different regimens of Vitamin D3 for 3 months. Vitamin D3-treated patients were supplemented by either daily oral 4000 IU Vitamin D3, weekly oral 50,000 IU Vitamin D3, or a single parenteral dose of 300,000 IU Vitamin D3. In addition to the assessment of patient characteristics, laboratory measurements of serum creatinine, blood urea, total and ionized calcium, serum phosphorus, fasting blood glucose, fasting serum insulin, homeostasis model assessment of insulin resistance, hemoglobin A1c, and 25(OH) Vitamin D levels were measured at the beginning and after 3 months. Results: After 3 months, the increased Vitamin D levels resulting from the daily and weekly oral doses of Vitamin D3 caused a significant decrease in metabolic parameters, whereas the parenteral dose demonstrated a non-significant decrease. Conclusion: Oral daily and weekly doses of Vitamin D3 could improve glucose homeostasis equally in patients with T2DM and better than a single parenteral dose of Vitamin D3.

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Section: Discussionmentioning

confidence: 99%

The Impact of Different Regimens of Vitamin D3 on Glucose Homeostasis in Type 2 Diabetic Patients

Ali

Ghanem

Sharaki

et al. 2019

Asian J Pharm Clin Res

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show abstract

“…Sunt studii care confirmă efecte benefice ale suplimentelor cu vitaminei D, dar și studii care nu au observat niciun impact al vitaminei D asupra parametrilor asociați cu rezistența la insulină în cazul pacienților cu DZ2 sau la cei cu prediabet [23][24][25][26][27][28]. Unele studii clinice au arătat că suplimentarea cu vitamina D reduce nivelul unor parametri precum colesterolul total, LDL, TG, HbA1c, precum și a indicatorului de rezistență la insulină -HOMA-IR la pacienții cu DZ2 [29,30].…”

Section: Roluri Fiziologice Ale Vitaminei Dunclassified

Vitamin D deficiency and insulin resistance

Miricescu¹,

Totan²,

Stănescu³

et al. 2019

Ro J Med Pract.

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RezumatVitamina D (colecalciferolul) este activă în organismul uman în urma a două reacții de hidroxilare. Odată activată, este implicată în metabolismul osos, dar mai poate influența și alte procese biologice precum creșterea și proliferarea celulară sau angiogeneza. Studii realizate până în prezent sugerează o legătură între deficiența de vitamină D și rezistența la insulină. Scopul acestui review este de a analiza efectele hipovitaminozei D, dar și ale administrării de suplimente bogate în vitamină D asupra rezistenței la insulină, prin intermediul datelor furnizate de literatura de specialitate. AbstractVitamin D or cholecalciferol is active in the human body after two hydroxylation reactions. Once activated, it is involved in bone metabolism, but can also influence other biological processes such as cell growth and proliferation or angiogenesis. Studies conducted so far suggest a link between vitamin D deficiency and insulin resistance. The purpose of this review is to analyze the effects of hypovitaminosis D as well as the administration of vitamin D rich supplements on the insulin resistance provided by the specialized literature.

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“…Vitamin D deficiency is associated with a higher risk of developing type 2 diabetes (T2D). Studies suggest that vitamin D supplementation may improve glycemic controls and insulin sensitivity [11,12]. Sphingolipid signaling is also involved in the development of T2D [3,4].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D3 Supplementation Increases Long-Chain Ceramide Levels in Overweight/Obese African Americans: A Post-Hoc Analysis of a Randomized Controlled Trial

et al. 2020

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Sphingolipid metabolism plays a critical role in cell growth regulation, lipid regulation, neurodevelopment, type 2 diabetes, and cancer. Animal experiments suggest that vitamin D may be involved in sphingolipid metabolism regulation. In this study, we tested the hypothesis that vitamin D supplementation would alter circulating long-chain ceramides and related metabolites involved in sphingolipid metabolism in humans. We carried out a post-hoc analysis of a previously conducted randomized, placebo-controlled clinical trial in 70 overweight/obese African-Americans, who were randomly assigned into four groups of 600, 2000, 4000 IU/day of vitamin D 3 supplements or placebo for 16 weeks. The metabolites were measured in 64 subjects (aged 26.0 ± 9.4 years, 17% male). Serum levels of N-stearoyl-sphingosine (d18:1/18:0) (C18Cer) and stearoyl sphingomyelin (d18:1/18:0) (C18SM) were significantly increased after vitamin D 3 supplementation (ps < 0.05) in a dose-response fashion. The effects of 600, 2000, and 4000 IU/day vitamin D 3 supplementation on C18Cer were 0.44 (p = 0.049), 0.52 (p = 0.016), and 0.58 (p = 0.008), respectively. The effects of three dosages on C18SM were 0.30 (p = 0.222), 0.61 (p = 0.009), and 0.68 (p = 0.004), respectively. This was accompanied by the significant correlations between serum 25-hydroxyvitamin D 3 [25(OH)D] concentration and those two metabolites (ps < 0.05). Vitamin D 3 supplementations increase serum levels of C18Cer and C18SM in a dose-response fashion among overweight/obese African Americans.

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Effect of oral vitamin D supplementation on glycemic control in patients with type 2 diabetes mellitus with coexisting hypovitaminosis D: A parellel group placebo controlled randomized controlled pilot study

Cited by 44 publications

References 20 publications

The Impact of Different Regimens of Vitamin D3 on Glucose Homeostasis in Type 2 Diabetic Patients

The Impact of Different Regimens of Vitamin D3 on Glucose Homeostasis in Type 2 Diabetic Patients

Vitamin D deficiency and insulin resistance

Vitamin D3 Supplementation Increases Long-Chain Ceramide Levels in Overweight/Obese African Americans: A Post-Hoc Analysis of a Randomized Controlled Trial

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