Effect of orally administered bovine lactoferrin on the immune response in the oral candidiasis murine model

Takakura, Natsuko; Wakabayashi, Hiroyuki; Ishibashi, Hidetoshi; Yamauchi, Koji; Teraguchi, Susumu; Tamura, Yoshitaka; Yamaguchi, Hideyo; Abe, Shigeru

doi:10.1099/jmm.0.05505-0

Cited by 56 publications

(30 citation statements)

References 34 publications

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“…Another recent study, however, has reported a role of Lf in the increased recruitment of neutrophils in blood, thus protecting mice from bacteremia [103]. Takakura et al [53] also showed that alleviation of oral candidiasis by Lf feeding to mice is correlated with the enhancement of the number of leukocytes and their cytokine responses in regional lymph nodes against candida infection.…”

Section: Role In the Recruitment Of Leukocytes At Infl Ammation Sitesmentioning

confidence: 96%

“…Furthermore, the susceptibility to tuberculosis of b-2-microglobulin knockout mice was abolished by Lf treatment [49]. Oral administration of Lf also revealed host-protecting effects against microbial infections [50], during lethal bacteraemia in mice [51,52] and against oral candidiasis [53]. Finally, orally administered Lf was shown to protect piglets against septic shock [54].…”

Section: In Vivo Evidence For Regulatory Roles Of Lfmentioning

confidence: 97%

“…A long-term bLf administration to chronic hepatitis C patients can produce a Th1-cytokine dominant environment in peripheral blood that favors the eradication of chronic hepatitis C virus by IFN therapy [101]. Upregulation of IFN-g and TNF-a production by cervical lymph node cells stimulated by heat-killed Candida albicans was observed in Lf-treated mice compared with non-treated mice [53].…”

Section: Pro-infl Ammatory Propertiesmentioning

confidence: 99%

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Lactoferrin

Legrand

Elass

Carpentier

et al. 2005

Cell. Mol. Life Sci.

358

117

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Lactoferrin is an iron-binding glycoprotein of the transferrin family. Abundant expression and secretion of lactoferrin, in particular in milk and fluids of the digestive tract, are related to its implication in the first line of host defense. Lactoferrin is also a prominent component of the secondary granules of neutrophils (PMNs) and is released in infected tissues and blood during the inflammatory process. In addition to its direct antimicrobial properties, the abilities of lactoferrin to regulate the immune response and to protect against infection and septic shock have been described in numerous in vitro and in vivo studies. Although the cellular and molecular mechanisms that account for the modulation of the inflammatory and immune responses by lactoferrin are not yet totally elucidated, many are now established. At the cellular level, lactoferrin modulates the migration, maturation and function of immune cells. At the molecular level and in addition to iron binding, interactions of lactoferrin with a plethora of compounds, either soluble or membrane molecules, account for its modulatory properties. This paper reviews our current understanding of the cellular and molecular mechanisms that explain the regulatory properties of lactoferrin in host defence.

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Section: Role In the Recruitment Of Leukocytes At Infl Ammation Sitesmentioning

confidence: 96%

Section: In Vivo Evidence For Regulatory Roles Of Lfmentioning

confidence: 97%

Section: Pro-infl Ammatory Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Lactoferrin

Legrand

Elass

Carpentier

et al. 2005

Cell. Mol. Life Sci.

358

117

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“…Even though Lf has numerous immune-stimulating properties [134][135][136], little is known about the actual mechanisms involved. Intracellular localization of Lf may result in regulation of host cell protein expression.…”

Section: Intracellular Targets For Lfmentioning

confidence: 99%

Anti herpes simplex virus activity of lactoferrin/lactoferricin – an example of antiviral activity of antimicrobial protein/peptide

Jenssen¹

2005

Cell. Mol. Life Sci.

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One of the most common viral infections in humans is caused by the herpes simplex virus (HSV). It was first effectively treated in the 1970s with the introduction of acyclovir, which is still the most commonly used treatment. Naturally occurring antimicrobial proteins and peptides have also been shown to possess antiviral activity against HSV. This review will focus on the anti-HSV activity of one such protein, lactoferrin, and a small peptide fragment from its N-terminal domain, lactoferricin. Both components have been shown to effectively block entry of HSV into the host cell. In addition to blocking HSV entry, the peptides appear to have immune stimulatory activity, although this is still somewhat controversial. Mode of action studies and knowledge about the anti-HSV activity of lactoferricin have also been successfully employed in the design of new, more specific HSV blockers.

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“…Ingestion of LF or its peptides improves the resolution of symptoms or the survival rate, reduces levels of pathogens in the body, and maintains homeostasis in animals or humans infected with bacteria (2, 4), fungi (24,36,38), protozoa (7), or viruses (8,21,26,33). Immunomodulatory effects of LF are thought to mediate these effects, because the following effects of orally administered LF have been reported in animal studies (27): enhancement of Th1 cytokine responses in splenocytes and lymph node cells (25,33), enhancement of effector cell activities in peritoneal macrophages and splenic NK cells (19,35), and increases in leukocyte numbers in the blood and lymphoid tissues (10,25,33,37). The primary target of orally administered LF may be the intestinal immune system, because intact LF or its functional fragments, which include the antimicrobial peptide lactoferricin B and antibody-reacting peptides, are rarely transferred to the blood after feeding in adult animals without injury in the gut (34).…”

mentioning

confidence: 99%

Modulation of Immunity-Related Gene Expression in Small Intestines of Mice by Oral Administration of Lactoferrin

Wakabayashi

Takakura

Yamauchi

et al. 2006

Clin Vaccine Immunol

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Oral administration of lactoferrin (LF), an antimicrobial and immunomodulatory protein, shows a protective effect against infectious diseases, possibly via immunomodulation of the host. Initially, we confirmed an immunomodulatory effect of LF by observing changes in the number of cells in the leukocyte subsets in the peripheral blood and spleens of mice 1 day after oral administration of LF. Then we developed a quantitative reverse transcription-PCR method for 20 immunity-related genes of antimicrobial proteins, pattern recognition receptors, cytokines, and lymphocyte mobilization-related proteins, and we assessed the expression of these genes in the small intestines of mice 2 h after administration of water, bovine serum albumin (BSA), or LF. Expression of the LF gene was lower in mice administered LF than in mice administered water or BSA, implying a negative-feedback control. Expression of gamma interferon (IFN-␥) and interleukin-10 (IL-10) was lower in both BSA-and LF-administered mice than in water administered mice, suggesting a nonspecific effect of protein ingestion. Expression of NOD2, IFN-␤, and IL-12p40 was higher with LF administration than with water or BSA administration. The expression levels of these three genes were correlated. This study indicated that oral administration of LF modulates the small intestinal expression of genes closely related to the host defense in a specific or a nonspecific manner.

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Effect of orally administered bovine lactoferrin on the immune response in the oral candidiasis murine model

Cited by 56 publications

References 34 publications

Lactoferrin

Lactoferrin

Anti herpes simplex virus activity of lactoferrin/lactoferricin – an example of antiviral activity of antimicrobial protein/peptide

Modulation of Immunity-Related Gene Expression in Small Intestines of Mice by Oral Administration of Lactoferrin

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