Effect of oregano essential oil on the engraftment and development of Lewis carcinoma in F1 DBA C57 black hybrid mice

Essential Oils of Oregano: Biological Activity beyond Their Antimicrobial Properties

“…An in vivo study reported that low doses of EOO in a three-month period exerted preventive action by decreasing the sizes of tumors by 1.5 times in diseased animals. It was suggested that the EOO could possible affect the development and progression of the tumor process via the activation of regulator cell molecules [ 158 ]. The in vitro antitumor activity of EOs of O. onites , was analyzed against rat adipose tissue endothelial cells and c-H-ras transformed rat embryonic fibroblasts (5RP7) cells.…”

“…Nonetheless, investigations about anticarcinogenic effect of EOO are scarce. Likewise, there are considerably fewer works dedicated to the biological activity of EOs using cell cultures and using in vivo models [ 158 ]. Furthermore, the molecular targets at the genome level and the involved genetic pathways of the mechanisms of EOO are remaining poorly explored [ 164 ].…”

Antiradical properties of essential oils and extracts from clove bud and pimento

“…More over, experiments with animals showed that clove essential oil demonstrated properties of biological antioxidants in vivo in low doses when introduced to mice for 6 months [6]. Study of the biological activity of essential oils of oregano, savory, clove and the extract of ginger showed a promising effect of the uptake of small doses of these and other essential oils for the prophylaxis of diseases connected with oxida tive stress and an increase of longevity [10,11].…”

“…For example, the essential oils of oregano, savory, clove, and lemon and the extract of ginger increased the antioxidant and immune status of labo ratory mice. They also provided geroprotective, anti tumor, and antiradiation effects [6][7][8][9][10][11]. In many cases the biological activity of essential oils and extracts is provided by their antioxidant and antiradical proper ties, which are due to the presence of volatile phenols, flavonoids, phenolic acids, etc.…”

Antiradical properties of essential oils and extracts from coriander, cardamom, white, red, and black peppers

“…Thus, long term admin istration of low doses of savory and oregano resulted in delayed aging in laboratory mice, an increased level of polyunsaturated fatty acids in the brain of aging ani mals, and improved brain function [10]. EOs of savory, oregano, clove, which contain phenols, and ginger extract manifested themselves in experiments in vivo as effective bioantioxidants; they improved the antiox idant and immune status of mice, increased their resis tance to radiation and carcinogens, and extended their lifespan [11][12][13][14]. Most EOs possess AO, antiviral, anticancer, anti inflammatory, and geroprotective activity and prevent the onset of cardiovascular dis eases [1,2,9,[14][15][16].…”