Red mud residue from alumina production has been proposed as an alternative liner material. The chemical and environmental compatibility of red mud upon exposure to representative organic (methanol, heptane, TCE, and acetic acid) and inorganic liquids (CaCl 2 and seawater) was studied. Chemical compatibility assays comprised Atterberg limits and sedimentation and hydraulic conductivity tests for red mud interacted with the chemical liquids, whereas the environmental compatibility was assessed through the leaching of metals from red mud as permeated with the liquids. Methanol greatly reduced the plasticity at concentrations C80 % by volume, but it did not increase the hydraulic conductivity of compacted red mud. High concentrations (C60 % v/v) of acetic acid reduced the plasticity and enhanced the sedimentation of red mud. Conversely, acetic acid concentrations B40 % caused dispersion, but damaged the hydraulic properties and structure of red mud. The percolation of a pH 2 acetic acid solution did not adversely affect the hydraulic performance of the red mud liner. Neither diluted heptane nor TCE affected the red mud. However, pure organics suppressed the plasticity and induced aggregation of red mud, suggesting a great detrimental effect on red mud liners. The red mud exhibited great resistance to attack by inorganic salt solutions. Some concerning leaching of metals (primarily Al and Cr) occurred as water, acetic acid, and CaCl 2 solutions percolated through red mud, but effluent metals concentration quickly dropped to permissible levels. In general, red mud exhibited a high resistance against chemical attack; nevertheless, exposure to low-dielectric-constant organic chemicals should be avoided.