a b s t r a c tNitrate losses are the dominant cause of the non-point source pollution under agricultural fields. In this study, the HYDRUS-2D model was first calibrated and validated using data collected during a two-year field investigation in a drip-irrigated maize field and then applied to evaluate the influence of 176 different N-managed water-saving irrigation scenarios on water and N dynamics and maize grain yield. Various scenarios were defined by combining 11 irrigation levels (IL = 0-100% with a 10% interval), 8 N fertilization rates (NR = 0-400 kg ha −1 with a 50 kg ha −1 interval) and two water-saving irrigation strategies: deficit irrigation (DI) and partial root-zone drying (PRD). Reliable estimates of soil NO 3 − -N concentrations (RMSE = 0.39-10.9 mg l −1 and MBE = −8.9-8.4 mg l −1 ), crop N uptake (RMSE = 3.9-8.9 kg ha −1 and MBE = −5.3-6.25 kg ha −1 ), and soil water contents (RMSE = 2.3-5.11 mm and MBE = 1.63-4.93 mm) were provided by HYDRUS-2D. Based on the simulated results, the fertigation strategy with NR = 200 kg ha −1 is an optimum strategy. For the higher fertigation rates (NR ≥ 250 kg ha −1 ), the NO 3 − -N leaching out of the surface layers (0-20 cm) increased by 0.1-183% while N uptake was enhanced by only 0.3-15%. On the other hand, reducing NR below this level would have resulted in severe economic losses. A 30% reduction in IL at NR = 200 kg ha −1 shows an enormous potential in lowering N leaching below different soil layers (12-99%) while reducing crop N uptake by only 5.4%. In addition, higher crop yield by 0.2-20.2% can be expected under PRD since crop N uptake is enhanced by more water available in the surface layers. While on the one hand, PRD ensures environmentally safer fertilizer applications, on the other hand, the economic objectives are met more easily under PRD than under DI. Additionally, it could be concluded that the HYDRUS-2D model, instead of labor-and time-consuming and expensive field investigations, could be reliably used for determining the optimal scenarios under both the DI and PRD strategies.