Effect of orlistat on weight loss, hormonal and metabolic profiles in women with polycystic ovarian syndrome: a randomized double-blind placebo-controlled trial

Moini, Ashraf; Kanani, Mahia; Kashani, Ladan; Hosseini, Reihaneh; Hosseini, Ladan

doi:10.1007/s12020-014-0426-4

Cited by 29 publications

(62 citation statements)

References 23 publications

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“…In terms of applicability, we found that the valid and important studies may not be highly applicable in our setting. The reason being is that although the age group and clinical characteristics were similar to that of our setting (that is, women of reproductive age with PCOS-related obesity), we found several issues regarding different ethnicity which potentially causes different dietary habit, the side effects reported by Moini et al [15] , and drug's feasibility. Orlistat is readily available in Indonesia yet it is rather expensive.…”

Section: Critical Appraisalmentioning

confidence: 67%

“…However, they used small sample size and did not use blinding method, making the study susceptible to observer bias. The study by Moini et al [15] was also considered strong, had a proper recruitment process and randomization for the same reasons as above. In addition, they also utilized double blinding method to prevent observer bias.…”

Section: Discussionmentioning

confidence: 99%

“…From the search selection and filtration above, two eligible RCT articles were selected to be reviewed: Kumar Both selected studies were critically appraised for their validity, importance, and applicability. Both studies from Kumar and Arora [14] and Moini et al [15] failed to mention allocation method. Nevertheless, the two studies fulfilled 4 out of 6 validity criteria, thus regarded as valid.…”

Section: Critical Appraisalmentioning

confidence: 99%

“…There were statistically significant reduction in weight, BMI, and WHR between intervention and control groups (Table 3). Moini et al [15] also reported about adverse events experienced by 50% of the patients in the intervention group including oily spotting, oily stools, and headache. In contrast to previous study, this study might be more similar to Indonesia in terms of dietary habit as it was conducted in Iran.…”

Section: The Evidencementioning

confidence: 99%

“…Moini et al [15] conducted a randomized, double-blind, controlled trial, which involved 100 patients that were randomized into two groups using randomization table method. Participants recruited were female aging between 19-38 years old with PCOS and BMI >25 kg/m 2 .…”

Section: The Evidencementioning

confidence: 99%

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The Effect of Orlistat as an Adjuvant to Lifestyle Modification on Weight Loss in Polycystic Ovary Syndrome Patients:An Evidence-Based Case Report

André¹,

Aristyo²,

Zhafira³

et al. 2017

IOSRPHR

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: Polycystic ovary syndrome (PCOS) occurs in 1 of 10 women of reproductive age. This syndrome is highly associated with obesity. Therefore, many of the patients face weight loss challenges. Given that many patients find it rather difficult to change their lifestyle, medicamentous intervention poses an option. Orlistat is an inhibitor of carboxyl ester lipase which inhibits the hydrolysis of dietary triglycerides that decreases the absorption of fatty acids and monoglyceride. The purpose of this study is to determine whether administration of orlistat can improve diet and exercise-induced body weight reduction in PCOS patients with obesity. Literature searching was done in 3 databases: PubMed, Cochrane Library, and Embase which yielded 141 articles. Findings were narrowed down using duplicate removal, inclusion and exclusion criteria into two relevant articles of randomized controlled trials. One randomized clinical trial showed a greater percentage in weight loss in PCOS patients BMI>23 kg/m2 administered with orlistat and lifestyle modification in comparison to lifestyle modification alone (7.81% (6.51-9.11%) vs 4.7% (4.19-5.21%) ; p<0.001). Similar body weight reduction was also found by another randomized clinical trial in PCOS patients BMI>25 kg/m2 with orlistat treatment (from 81.5 kg (80.3-82.7) to 76.2 kg (74.92-77.48) vs from 80.91 kg (79.65-82.17) to 79.15 kg (77.8-80.5) ; p<0.01). It was concluded that a considerable reduction of weight in obese and overweight PCOS patients was found when given orlistat with exercise and dietary interventions compared to exercise and dietary interventions alone.

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Section: Critical Appraisalmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Critical Appraisalmentioning

confidence: 99%

Section: The Evidencementioning

confidence: 99%

Section: The Evidencementioning

confidence: 99%

See 3 more Smart Citations

The Effect of Orlistat as an Adjuvant to Lifestyle Modification on Weight Loss in Polycystic Ovary Syndrome Patients:An Evidence-Based Case Report

André¹,

Aristyo²,

Zhafira³

et al. 2017

IOSRPHR

View full text Add to dashboard Cite

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Bridging gap in treatment of polycystic ovarian syndrome through drug repurposing: what we achieved and where we are?

Kumbhar,

Chavan,

Darekar

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials

Abdalla

Shah

Deshmukh

et al. 2022

Arch Gynecol Obstet

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Context: Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterised by insulin resistance and is a major cause of type 2 diabetes mellitus (T2DM). Objective: To review the literature on the effect of different pharmacological interventions on insulin resistance in women with PCOS. Data sources: We searched PubMed, MEDLINE, Scopus, Embase, Cochrane library and the Web of Science in April 2020 and updated in March 2021. Study selection: The study follows the 2020 Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Data extraction: Reviewers extracted data and assessed the risk of bias using the Cochrane risk of bias tool.Data synthesis: 58 RCTs there were significant reductions in the fasting blood glucose (FBG) with metformin vs placebo (mean difference (MD): -0.16 mg/dL; 95%

show abstract

Effect of orlistat on weight loss, hormonal and metabolic profiles in women with polycystic ovarian syndrome: a randomized double-blind placebo-controlled trial

Cited by 29 publications

References 23 publications

The Effect of Orlistat as an Adjuvant to Lifestyle Modification on Weight Loss in Polycystic Ovary Syndrome Patients:An Evidence-Based Case Report

The Effect of Orlistat as an Adjuvant to Lifestyle Modification on Weight Loss in Polycystic Ovary Syndrome Patients:An Evidence-Based Case Report

Bridging gap in treatment of polycystic ovarian syndrome through drug repurposing: what we achieved and where we are?

Impact of pharmacological interventions on biochemical hyperandrogenemia in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials

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