Effect of Orthodontic Appliances on Oral Microbiota—6 Month Follow-up

Topaloglu-Ak, Aslı; Ertuğrul, Fahinur; Eden, Ece; Ateş, Mustafa; Bulut, Hacer Kobya

doi:10.17796/jcpd.35.4.61114412637mt661

Cited by 75 publications

(82 citation statements)

References 7 publications

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“…Six studies analyzed removable devices [11,17,18,31,49,52]. One study analyzed different interceptive removable appliances [49], demonstrating an increase in both S. mutans and Lactobacillus spp.…”

Section: Resultsmentioning

confidence: 99%

Changes in oral microbiota due to orthodontic appliances: a systematic review

Lucchese

Bondemark

Marcolina

et al. 2018

Journal of Oral Microbiology

141

115

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Background: Oral microbiota has been at the center of cultural attention in recent years. In daily clinical practice, orthodontic appliances may be associated with an increased cariogenic risk and a worsening of preexisting periodontal diseases.Objective: The purpose of this review is to investigate the available evidence regarding the association between orthodontic appliances and changes in the quality and quantity of the oral microbiota.Design: The research included every article published up to October 2017 featuring the keywords ‘Orthodontic appliance* AND (microbiological colonization OR periodontal pathogen* OR Streptococcus mutans OR Lactobacillus spp. OR Candida OR Tannerella forsythia OR Treponema denticola OR Fusobacterium nucleatum OR Aggregatibacter actinomycetemcomitans OR Prevotella intermedia OR Prevotella nigrescens OR Porphyromonas gingivalis)’ and was conducted in the major medical databases. The methodological quality of selected papers was scored using the ‘Swedish Council on Technology Assessment in Health Care Criteria for Grading Assessed Studies’ (SBU) method.Results: Orthodontic appliances influence the oral microbiota with an increase in the counts of S. mutans and Lactobacillus spp. and in the percentage of potentially pathogenic gram-negative bacteria.Conclusions: There is moderate/high evidence regarding the association between orthodontic appliances and changes in the oral microbiota.PROSPERO registration number CRD42018091589.

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Section: Resultsmentioning

confidence: 99%

Changes in oral microbiota due to orthodontic appliances: a systematic review

Lucchese

Bondemark

Marcolina

et al. 2018

Journal of Oral Microbiology

141

115

View full text Add to dashboard Cite

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“…Orthodontic appliances can change oral microflora, increase the levels of periodontal pathogens (7) and Streptococcus mutans (1,(8)(9)(10) in the saliva and dental biofilms during orthodontic treatment.…”

Section: Introductionmentioning

confidence: 99%

“…Such changes may be responsible for the increased susceptibility to the development of carious lesions, with or without cavitation, during orthodontic treatments (10,15).…”

Section: Introductionmentioning

confidence: 99%

Quantification of Streptococcus mutans in Different Types of Ligature Wires and Elastomeric Chains

et al. 2017

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This study aimed to test the hypothesis that Streptococcus mutans contamination levels differ according to the type of the orthodontic ligature. Thirteen patients were selected. Each quadrant was randomly subjected to one of the following ligature-use protocols: I) elastomeric chain, II) steel ligature crossed over the archwire, III) steel ligature crossed under the archwire, and IV) steel ligature in a figure-eight pattern under the archwire. After seven days, the devices were removed and the Streptococcus mutans colony-forming unit count per mg of biofilm weight was determined. Twelve specimens (n=3) were also processed for scanning electron microscopy analysis. ANOVA and Tukey-Kramer test were used for comparisons to assess S. mutans differences between groups at a 5% significance level. There was no statistical difference in detectable levels of S. mutans among the groups (p=0.294). Scanning electron microscopy results showed abundant biofilms and microbial contamination in all groups. In conclusion, S. mutans contamination levels are similar in the different orthodontic ligatures.

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“…[3][4][5] It is challenging which results from higher number of plaque-retentive sites and impaired mechanical plaque removal that most often seen with BOA. 6 The BOA also may affect the composition, metabolic activity, pathogenicity of the biofilm.…”

mentioning

confidence: 99%

Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Doubleblind Cross-over Clinical Trial

Ghorbanzadeh¹,

Pourakbari²,

Bahador³

2015

The Journal of Contemporary Dental Practice

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Aim Polymethyl-methacrylate (PMMA) is commonly used primarily for baseplates of orthodontic appliances (BOA). The activities of cariogenic bacteria in biofilm on these surfaces may contribute to dental caries, gingival inflammation and periodontal disease. The PMMA incorporated with nanoparticles of silver (NanoAg-I-PMMA) and NanoAg in situ in PMMA (NanoAg-IS-PMMA) have been shown to control the growth of cariogenic bacteria, but clinical trial of anti-cariogenic application of these novel materials in orthodontics has not been evaluated. The main aim of the study is to compare the clinical effectiveness of using NanoAg-IS-PMMA and NanoAg-I-PMMA for construction of new BOA in inhibiting the planktonic growth and biofilm formation of the cariogenic bacteria. Materials and methods Twenty four patients with a median age of 12.6 years (7-15) harboring Streptococcus mutans, Streptococcus sobrinus and Lactobacillus acidophilus as well as Lactobacillus casei participated in the randomized, doubleblind, cross-over study. The experimental BOA, NanoAg-ISBOA and NanoAg-I-BOA, contained 0.5% w/w NanoAg while the control BOA was standard PMMA. Antibacterial effect of NanoAg-IS-BOA and NanoAg-I-BOA was assessed against test cariogenic bacteria by planktonic and biofilm bacterial cells growth inhibition. Results The average levels of test cariogenic bacteria in saliva decreased about 2 to 70 fold (30.9-98.4%) compared to baseline depending on the microorganism type and test BOA. Biofilm inhibition analysis demonstrated that NanoAg-I-BOA and NanoAg-IS-BOA inhibited the biofilm of all test bacteria by 20.1 to 79.9% compared to BOA. NanoAg-IS-BOA had a strong anti-biofilm effect against S. mutans, S. sobrinus and L. casei. However, NanoAg-I-BOA showed only slight antibiofilm effects on test bacteria. Most notably, at all period of the clinical trial, NanoAg-IS-BOA showed a higher antibacterial activity than NanoAg-I-BOA. Conclusion Based on the novel data that presented here, the NanoAg-IS-BOA had strong antimicrobial activity in the planktonic phase and subsequent biofilm formation of the cariogenic bacteria. Clinical significance Wearing of NanoAg-IS-BOA has the potential to minimize dental plaque formation and caries during orthodontic treatment. How to cite this article Ghorbanzadeh R, Pourakbari B, Bahador A. Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Double-blind Cross-over Clinical Trial. J Contemp Dent Pract 2015;16(4):291-298.

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Effect of Orthodontic Appliances on Oral Microbiota—6 Month Follow-up

Cited by 75 publications

References 7 publications

Changes in oral microbiota due to orthodontic appliances: a systematic review

Changes in oral microbiota due to orthodontic appliances: a systematic review

Quantification of Streptococcus mutans in Different Types of Ligature Wires and Elastomeric Chains

Effects of Baseplates of Orthodontic Appliances with in situ generated Silver Nanoparticles on Cariogenic Bacteria: A Randomized, Doubleblind Cross-over Clinical Trial

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