Effect of Orthophosphates and Citrates in Fluoride Toothpastes on Plaque pH (Short Communication)

Duke, Suzanne; Reading, J.P.; Jackson, Richard

doi:10.1159/000261136

Cited by 5 publications

(7 citation statements)

References 15 publications

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“…Acid citrate and citric acid at relatively low concentrations are known to inhibit phosphofructokinase. 57 Due to this inhibition of glycolytic enzymes, it may, therefore, reduce the acid which forms in the dental plaque by bacterial fermentation of sugars. Another comment made was that the stimulation of salivary flow by citrate may lead to quicker clearance of acid after an acidogenic challenge.…”

Section: Modifying Agents: Citratementioning

confidence: 99%

Soft drinks and dental health: A review of the current literature

Tahmassebi

Duggal

Malik-Kotru

et al. 2006

Journal of Dentistry

245

173

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Section: Modifying Agents: Citratementioning

confidence: 99%

Soft drinks and dental health: A review of the current literature

Tahmassebi

Duggal

Malik-Kotru

et al. 2006

Journal of Dentistry

245

173

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“…Al though there are no previous data with which to compare the results of our study, these findings can to some extent be explained on the basis of the known effect of citrate on plaque pH. Acid citrates and citric acid in relatively low concentrations are known to inhibit phosphokinase and may thus reduce the acid formation in the plaque [Duke et al, 1988]. On the other hand higher levels of acid citrates in drinks can have two possible effects.…”

Section: Discussionmentioning

confidence: 56%

“…It has been reported [Duke et al, 1988] that moderate levels of citrate in drinks reduced the acidogenic re sponse in the plaque. In our study it can be seen that all drinks containing citrate produced a significantly reduced acidogenic response in the dental plaque as compared with a pure 10% sucrose solution (chi-square = 25.3350, pcO.0001).…”

Section: Discussionmentioning

confidence: 99%

“…Edgar et al [1975] compared the potential cariogenic ity of different drinks and found that cola drinks that con tain phosphoric acid, and orange juice, which contains a high level of citric acid, produce essentially the same plaque pH response. However moderate levels of citrates in tooth pastes have been shown to reduce the fall in the plaque pH after a sucrose challenge [Duke et al, 1985[Duke et al, , 1988. It has been thought that factors, such as the citrate content in drinks, may modify the carbohydrate-derived acidogenic challenge of that drink.…”

mentioning

confidence: 99%

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The Effect of Different Concentrations of Citrate in Drinks on Plaque pH

Pollard¹,

Duggal²,

Curzon³

1993

Caries Res

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The effect of 0.1, 0.2 and 0.4% citrate in 10% sucrose solutions on the plaque pH in vivo was tested in 20 volunteers using the plaque harvesting technique. Results showed that the pH response for the three test solutions with citrate was significantly less compared with that for 10% sucrose (positive control) alone (p < 0.05). Mean areas under the pH curve were: sorbitol (negative control) 0.02, citrate 0.2% 5.30, citrate 0.4% 6.24, citrate 0.1% 6.94 and 10% 12.69. The cariogenic potential index of all the citrate test drinks was almost half compared with a 10% sucrose solution (p < 0.05). It was concluded that the addition of relatively low levels of citrate in a sucrose solution reduces the acidogenic response in the plaque.

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“…The models covered are animal caries, subdivided into diet and topical treatments; in situ studies; the ability to reduce plaque acid; and human data, subdivided into topical treatment and epidemiologic studies. Citrate is an interesting agent in that it might be expected to interfere with parts of the enzyme systems which produce acids in plaque, e.g., phosphofructokinase (Duke et al, 1988). From this survey, many metals could have anticaries potential.…”

Section: Metalsmentioning

confidence: 99%

Non-Fluoride Anticaries Agents

Forward¹

1994

Adv Dent Res.

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Many potential anticaries agents other than fluoride have been identified in a range of laboratory models. This review covers only those agents which have demonstrated significant activity in either animal caries models, in situ models, or human clinical trials, including those measuring plaque acid formation. The agents which so far have been identified can be divided into 5 categories: (1) phosphorus-containing agents, (2) calcium-containing agents, (3) antimicrobials and antibiotics, (4) metals, and (5) miscellaneous agents. Although many potential agents have been identified in various models, very few have been taken forward to full anticaries testing in humans. Chlorhexidine is an exception, and certain agents such as calcium glycerophosphate have been shown to result in greater anticaries activity when added to fluoride. In the future, non-fluoride agents which modify the production of acid in plaque--either antimicrobially, biochemically, or directly--appear to have the most promise for use in topical products and may prove to be effective anticaries systems. Phosphates have shown encouraging activity as diet additives.

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Effect of Orthophosphates and Citrates in Fluoride Toothpastes on Plaque pH (Short Communication)

Cited by 5 publications

References 15 publications

Soft drinks and dental health: A review of the current literature

Soft drinks and dental health: A review of the current literature

The Effect of Different Concentrations of Citrate in Drinks on Plaque pH

Non-Fluoride Anticaries Agents

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