Effect of osteoprotegerin gene polymorphisms on the risk of cervical spondylotic myelopathy in a Chinese population

Yu, Haiming; Chen, Xiaolei; Wu, Wei; Yao, Xuedong; Sun, Jing-Qun; Su, Xin; Lin, Shufeng

doi:10.1016/j.clineuro.2018.09.013

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…While the former conferred no significant difference in mJOA score, in the latter patients with the A allele had significantly worse mJOA scores than their G allele counterparts (p < 0.001). Yu et al (2018) found the TT genotype of the 950T>C polymorphism in the OPG gene to be associated with higher mJOA scores and fewer ossified vertebrae (p < 0.05); the TT genotype appears to be protective [42]. Wu et al (2014) investigated four polymorphisms of the OPN gene in 187 CSM patients, finding no significant difference of all four polymorphisms on the mJOA score [43].…”

Section: What Are the Genetic Effects On Clinical Severity Of Dcm?mentioning

confidence: 99%

“…There is conflicting evidence of the effect of the IVS15-14T>C polymorphism: one study found it to be associated with a 3.01 times risk of myelopathy development (p = 0.022) [40], while another found no significant effect (p = 0.320) [33]. Yu et al (2018) found no significant effect of the 1181G>C and 163A>G polymorphisms in the osteoprotegerin (OPG) gene, but found the C allele of the 950T>C SNP to be associated with a greater risk of myelopathy (p < 0.01) [42].…”

Section: Spinal Cord Pathologymentioning

confidence: 99%

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Genetics of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Candidate Gene Studies

Pope

Davies

Mowforth

et al. 2020

JCM

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Degenerative cervical myelopathy (DCM) is estimated to be the most common cause of adult spinal cord impairment. Evidence that is suggestive of a genetic basis to DCM has been increasing over the last decade. A systematic search was conducted in MEDLINE, EMBASE, Cochrane, and HuGENet databases from their origin up to 14th December 2019 to evaluate the role of single genes in DCM in its onset, clinical phenotype, and response to surgical intervention. The initial search yielded 914 articles, with 39 articles being identified as eligible after screening. We distinguish between those contributing to spinal column deterioration and those contributing to spinal cord deterioration in assessing the evidence of genetic contributions to DCM. Evidence regarding a total of 28 candidate genes was identified. Of these, 22 were found to have an effect on the radiological onset of spinal column disease, while 12 genes had an effect on clinical onset of spinal cord disease. Polymorphisms of eight genes were found to have an effect on the radiological severity of DCM, while three genes had an effect on clinical severity. Polymorphisms of six genes were found to have an effect on clinical response to surgery in spinal cord disease. There are clear genetic effects on the development of spinal pathology, the central nervous system (CNS) response to bony pathology, the severity of both bony and cord pathology, and the subsequent response to surgical intervention. Work to disentangle the mechanisms by which the genes that are reviewed here exert their effects, as well as improved quality of evidence across diverse populations is required for further investigating the genetic contribution to DCM.

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Section: What Are the Genetic Effects On Clinical Severity Of Dcm?mentioning

confidence: 99%

Section: Spinal Cord Pathologymentioning

confidence: 99%

Genetics of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Candidate Gene Studies

Pope

Davies

Mowforth

et al. 2020

JCM

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Fatigue in stroke survivors: a 5-year follow-up of the Fall study of Gothenburg

Schnitzer,

Hansson,

Samuelsson

et al. 2023

J Neurol

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Longer term knowledge of post-stroke fatigue (PSF) is limited. Our aim was to describe the prevalence of, and to identify baseline predictors associated with, PSF 5 years after stroke. We undertook a follow-up of stroke survivors from the 504 consecutively recruited participants in the observational “The Fall Study of Gothenburg”, conducted between 2014 and 2016. The dependent variable, PSF, was assessed using the Swedish version of the Fatigue Assessment Scale (S-FAS) and defined as having a S-FAS score ≥ 24. The S-FAS questionnaire was mailed to potential participants in August 2020. The independent variables, previously obtained from medical records, included age; sex; comorbidities; stroke severity; hospital length of stay; body mass index (BMI); number of medications and lifestyle factors at index stroke. To identify predictors of PSF, univariable and multivariable logistic regression analyses were performed. Of the 305 eligible participants, 119 (39%) responded with complete S-FAS. Mean age at index stroke was 71 (SD 10.4) years and 41% were female. After a mean of 4.9 years after stroke, the prevalence of PSF was 52%. Among those with PSF, almost two thirds were classified as having both physical and mental PSF. In the multivariable analysis, only high BMI predicted PSF with an odds ratio of 1.25 (95% CI 1.11–1.41, p < 0.01). In conclusion, half of the participants reported PSF 5 years after index stroke and higher body mass index was identified as a predictor. The findings from this study are important for healthcare professionals, for planning health-related efforts and rehabilitation of stroke survivors.ClinicalTrials.gov, Identifier NCT02264470.

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An exploratory cohort study of serum estradiol, testosterone, osteoprotegerin, interleukin-6, calcium, and magnesium as potential biomarkers of cervical spondylosis

Igwe,

Onyeso,

Adandom

et al. 2023

Bull Fac Phys Ther

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Background Exploration of biomarkers for debilitating diseases such as cervical spondylosis is important to revolutionize clinical diagnosis and management of such conditions. The study aimed to determine the correlation between neck pain and disability and serum levels of interleukin-6 (IL-6), osteoprotegerin (OPG), estradiol (E2), testosterone (TES), calcium (Ca), and magnesium (Mg) among individuals with symptomatic cervical spondylosis. Methods This study was a cohort design. The participants were new referrals to two Nigerian physical therapy clinics. Participants’ neck pain intensity (PI), neck disability index (NDI), IL-6, OPG, E2, TES, Ca, and Mg were measured at baseline and after 13 weeks of follow-up. Data were analyzed using descriptive statistics, independent samples t test, Pearson’s correlation, and multiple linear regression. Results Forty individuals aged 52.40 ± 8.60 years participated in the study. Women had significantly higher levels of IL-6 (t = − 2.392, p = 0.026), OPG (t = − 3.235, p = 0.005), E2 (t = − 6.841, p = 0.001), but lower TES (t = 17.776, p = 0.001). There were no significant sex differences in PI and NDI. There were significant correlations between PI and OPG (r = 0.385, p < 0.001), NDI and OPG (r = 0.402, p < 0.001), and IL-6 (r = 0.235, p = 0.036). Significant predictors of PI were OPG (β = 0.442, p < 0.001) and E2 (β = − 0.285, p = 0.011), and NDI were OPG (β = 0.453, p < 0.001), E2 (β = − 0.292, p = 0.005), and IL-6 (β = 0.225, p = 0.024). Conclusion High serum levels of IL-6 and OPG were associated with cervical spondylosis severity. However, high serum levels of E2 and TES correlated with lesser severity. Moreover, TES inversely correlated with the proinflammatory cytokines.

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Effect of osteoprotegerin gene polymorphisms on the risk of cervical spondylotic myelopathy in a Chinese population

Cited by 4 publications

References 29 publications

Genetics of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Candidate Gene Studies

Genetics of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Candidate Gene Studies

Fatigue in stroke survivors: a 5-year follow-up of the Fall study of Gothenburg

An exploratory cohort study of serum estradiol, testosterone, osteoprotegerin, interleukin-6, calcium, and magnesium as potential biomarkers of cervical spondylosis

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