Effect of osteosarcopenia on the development of a second compression fracture and mortality in elderly patients after vertebroplasty

doi:10.5152/j.aott.2023.23099

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…1 ). The prevalence largely varied from 2.78% [ 21 ] to 38.46% [ 20 ], leading to a substantial heterogeneity (I 2 = 99%).…”

Section: Resultsmentioning

confidence: 99%

Osteosarcopenia increases the risk of mortality: a systematic review and meta-analysis of prospective observational studies

Veronese,

Ragusa,

Sabico

et al. 2024

Aging Clin Exp Res

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Background & aims Osteosarcopenia is a recently recognized geriatric syndrome. The association between osteosarcopenia and mortality risk is still largely underexplored. In this systematic review with meta-analysis of prospective cohort studies, we aimed to explore whether osteosarcopenia could be associated with a higher mortality risk. Methods Several databases were searched from the inception to 16th February 2024 for prospective cohort studies dealing with osteosarcopenia and mortality. We calculated the mortality risk in osteosarcopenia vs. controls using the most adjusted estimate available and summarized the data as risk ratios (RRs) with their 95% confidence intervals (CIs). A random-effect model was considered for all analyses. Results Among 231 studies initially considered, nine articles were included after exclusions for a total of 14,429 participants (mean age: 70 years; 64.5% females). The weighted prevalence of osteosarcopenia was 12.72%. Over a mean follow-up of 6.6 years and after adjusting for a mean of four covariates, osteosarcopenia was associated with approximately 53% increased risk of mortality (RR: 1.53; 95% CI: 1.28–1.78). After accounting for publication bias, the re-calculated RR was 1.48 (95%CI: 1.23–1.72). The quality of the studies was generally good, as determined by the Newcastle Ottawa Scale. Conclusions Osteosarcopenia was significantly linked with an increased risk of mortality in older people, indicating the need to consider the presence of osteoporosis in patients with sarcopenia, and vice versa, since the combination of these two conditions typical of older people may lead to further complications, such as mortality.

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“…1 ). The prevalence largely varied from 2.78% [ 21 ] to 38.46% [ 20 ], leading to a substantial heterogeneity (I 2 = 99%).…”

Section: Resultsmentioning

confidence: 99%

Osteosarcopenia increases the risk of mortality: a systematic review and meta-analysis of prospective observational studies

Veronese,

Ragusa,

Sabico

et al. 2024

Aging Clin Exp Res

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“…The mechanical properties of PPF cement are akin to those of cancellous and cortical bone [ 41 ], and PPF displays efficient injectable properties [ 40 , 42 ]. For patients suffering from osteoporotic vertebral compression fractures, unbiased medical studies have demonstrated that the possibility of adjacent segment disease is greater in patients treated with PMMA bone cement than in those treated with other treatments [ 10 , 43 , 44 ]. The use of PPF as a substitute material for PMMA offers a resolution to the issues caused by the latter's high mechanical strength.…”

Section: Discussionmentioning

confidence: 99%

Incorporation of black phosphorus nanosheets into poly(propylene fumarate) biodegradable bone cement to enhance bioactivity and osteogenesis

Chen,

Huang,

Wang

et al. 2024

J Orthop Surg Res

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Background Injectable bone cement is commonly used in clinical orthopaedics to fill bone defects, treat vertebral compression fractures, and fix joint prostheses during joint replacement surgery. Poly(propylene fumarate) (PPF) has been proposed as a biodegradable and injectable alternative to polymethylmethacrylate (PMMA) bone cement. Recently, there has been considerable interest in two-dimensional (2D) black phosphorus nanomaterials (BPNSs) in the biomedical field due to their excellent photothermal and osteogenic properties. In this study, we investigated the biological and physicochemical qualities of BPNSs mixed with PPF bone cement created through thermal cross-linking. Methods PPF was prepared through a two-step process, and BPNSs were prepared via a liquid phase stripping method. BP/PPF was subsequently prepared through thermal cross-linking, and its characteristics were thoroughly analysed. The mechanical properties, cytocompatibility, osteogenic performance, degradation performance, photothermal performance, and in vivo toxicity of BP/PPF were evaluated. Results BP/PPF exhibited low cytotoxicity levels and mechanical properties similar to that of bone, whereas the inclusion of BPNSs promoted preosteoblast adherence, proliferation, and differentiation on the surface of the bone cement. Furthermore, 200 BP/PPF demonstrated superior cytocompatibility and osteogenic effects, leading to the degradation of PPF bone cement and enabling it to possess photothermal properties. When exposed to an 808-nm laser, the temperature of the bone cement increased to 45–55 °C. Furthermore, haematoxylin and eosin-stained sections from the in vivo toxicity test did not display any anomalous tissue changes. Conclusion BP/PPF exhibited mechanical properties similar to that of bone: outstanding photothermal properties, cytocompatibility, and osteoinductivity. BP/PPF serves as an effective degradable bone cement and holds great potential in the field of bone regeneration.

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Sarcopenia and the management of spinal disease in the elderly

Evans,

Smith,

Bakhsheshian

et al. 2024

GeroScience

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Effect of osteosarcopenia on the development of a second compression fracture and mortality in elderly patients after vertebroplasty

Cited by 3 publications

References 26 publications

Osteosarcopenia increases the risk of mortality: a systematic review and meta-analysis of prospective observational studies

Osteosarcopenia increases the risk of mortality: a systematic review and meta-analysis of prospective observational studies

Incorporation of black phosphorus nanosheets into poly(propylene fumarate) biodegradable bone cement to enhance bioactivity and osteogenesis

Sarcopenia and the management of spinal disease in the elderly

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