Effect of ovarian activity on orthodontic tooth movement and gingival crevicular fluid levels of interleukin-1β and prostaglandin E2 in cats

Çelebi, Ahmet Arif; Demirer, Serhat; Çatalbaş, Bülent; Arıkan, Şenay

doi:10.2319/012912-78.1

Cited by 26 publications

(19 citation statements)

References 35 publications

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“…Osteoclast activity can be inhibited by oestrogen in a direct or indirect manner, thereby modulating bone resorption [42]. This aspect is beyond the scope of this study since it focused on changes in IL-1β levels with time and also due to the unequal and small sample size with a male/female ratio of 7:3.…”

Section: Resultsmentioning

confidence: 99%

A study of interleukin 1β levels in peri-miniscrew crevicular fluid (PMCF)

et al. 2014

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BackgroundThis study provides a vital insight in assessing the clinical and biochemical changes in interleukin (IL)-1β levels in peri-miniscrew crevicular fluid (PMCF) during the course of orthodontic tooth movement.MethodsThe study comprised the analysis of IL-1β in peri-miniscrew crevicular fluid obtained from crevices around the miniscrews inserted in 11 patients (eight females and three males, mean age 17.3 ± 4.64 years) with all first premolar extraction and maximum anchorage requirement using miniscrew-supported anchorage. Miniscrews were loaded at 3 weeks after placement by 200-g nitinol closed coil springs of 9-mm length for en masse retraction. Peri-miniscrew crevicular fluid was collected at miniscrew placement (T1), at 3 weeks (T2/baseline) and on loading at 0 (T3) and 1 day (T4), 21 (T5), 72 (T6), 120 (T7), 180 (T8) and 300 (T9) days. IL-1β levels were estimated by enzyme-linked immunosorbent assay (ELISA). Peri-miniscrew tissue was examined for signs of inflammation, and also, miniscrew mobility was assessed with Periotest and handles of two mouth mirrors.ResultsIL-1β levels in all miniscrews were significantly higher at T1 and peaked again at T4 showing a bimodal peak. However, there was a gradual and statistically significant decrease in IL-1β till T5, while further changes till the end of the study were statistically not significant.ConclusionsThe changing levels of IL-1β levels in PMCF over a duration of 300 days are suggestive of the underlying inflammatory process. IL-1β levels in PMCF show a significant rise during miniscrew insertion and on immediate loading. The trend of gradually reducing IL-1β levels around the miniscrew over the period after loading towards baseline is suggestive of adaptive bone response to stimulus.

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Section: Resultsmentioning

confidence: 99%

A study of interleukin 1β levels in peri-miniscrew crevicular fluid (PMCF)

et al. 2014

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“…Animal studies have evaluated correlation between ovarian activity and PGE2, IL-1β levels in GCF of female cats during OTM. Results revealed that mediator levels of estrous groups were lower than anestrous and ovariectomized groups on 6 and 12 days, indicating that ovarian activity can affect OTM [ 76 ]. The threshold levels of the inflammatory mediators for initiation for OTM also remain unexplored.…”

Section: Discussionmentioning

confidence: 99%

Effect of orthodontic forces on cytokine and receptor levels in gingival crevicular fluid: a systematic review

et al. 2014

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This systematic review aimed to generate evidence on role of potent markers of inflammation [cytokines, chemokines, their associated receptors and antagonists] following the application of orthodontic forces. Subsequent to registration with PROSPERO, literature search followed a predetermined search strategy to key databases along with hand search (HS). Seventy-seven articles from PubMed (P), 637 from Scopus (S), 51 from Embase (E), and 3 from hand search (HS) were identified. A total of 39 articles were shortlisted that met strict inclusion and exclusion criteria and quality assessment. Each study was evaluated for participant characteristics, study design, oral hygiene regimen, and gingival crevicular fluid (GCF) handling. Among these studies, biomarkers in the order of frequency were interleukin (IL)-1β (N = 21), tumor necrosis factor (TNF)-α (N = 10), IL-8,IL-6(N=8), receptor activator of nuclear factor kappa-B ligand (RANKL) (N = 7), monocyte chemoattractant protein (MCP)-1 (N = 3), IL-2 (N=4), IL-4, IL-10, RANTES (N = 2), IL-1, IL-5, IL-1α, IP-10, osteopontin (OPN) (N = 1) and receptors and their antagonists in the order of osteoprotegerin (OPG) (N = 8), IL-1RA (N = 5), and RANK (N = 1). Results revealed an immediate release of inflammatory bone-resorptive mediators, IL-1β and TNF-α, where IL-1β increased as early as 1 min to 1 h reaching peak at 24 h while TNF-α increased at 1 h or 1 day. This was accompanied by a fall in bone-protective mediator (OPG) levels at 1 h and 24 h after orthodontic force application. Continuous forces were accompanied by a decrease in mediator levels after attaining peak levels (most commonly at 24 h) while repeated activations in interrupted force upregulated their secretion. Significant correlations of IL-1β levels with pain intensity, rate of orthodontic tooth movement (OTM) and of activity index (AI) (IL-1β/IL-1RA) with velocity of tooth movement and growth status of individuals have also been deduced. A greater AI and RANKL/OPG ratio was seen in juveniles as compared to adults or non-growers that were associated with faster rate of OTM in juveniles. None of the studies addressed the effect of estrous cycle in female subjects. Lack of homogeneity in several parameters calls for a better controlled research on the biology of OTM.Electronic supplementary materialThe online version of this article (doi:10.1186/s40510-014-0065-6) contains supplementary material, which is available to authorized users.

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“…It has been reported that estrogen deficiency accelerates OTM in OVX rats 2, 5, 17–20 . Arslan et al .…”

Section: Introductionmentioning

confidence: 98%

Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

Dai

Zhou

Zhang

et al. 2017

Sci Rep

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As the number of elderly orthodontic patients increases, the impact of postmenopausal osteoporosis on orthodontic tooth movement (OTM) has attracted a great deal of attention because OTM relies on alveolar bone remodeling. The question of whether OTM causes subsequent alveolar bone loss and is harmful to alveolar bone health under osteoporotic conditions remains to be answered. The present study aimed to clarify the influences of OTM on alveolar bone in osteoporotic rats. OTM was accelerated in ovariectomized (OVX) rats as a result of increased bone resorption in the pressure area. At the same time, anabolic bone formation was promoted in the tension area during OTM in OVX rats. Micro-CT analysis of alveolar bone revealed a decrease in BMD, BV/TV and Tb.Th. in the OTM group compared with that in non-OTM rats on day 21 of OTM, suggesting that OTM caused alveolar bone loss in OVX rats during OTM. However, the OTM-induced bone loss could be recovered 3 months after OTM in OVX rats. Thus, our findings suggest that increased osteogenesis may compensate for the increased bone resorption during and after OTM and enable effective accelerated OTM in OVX rats.

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Effect of ovarian activity on orthodontic tooth movement and gingival crevicular fluid levels of interleukin-1β and prostaglandin E2 in cats

Abstract: These results indicate that ovarian activity can affect orthodontic tooth movement and GCF levels of IL-1β and PGE(2) in cats.

Cited by 26 publications

References 35 publications

A study of interleukin 1β levels in peri-miniscrew crevicular fluid (PMCF)

A study of interleukin 1β levels in peri-miniscrew crevicular fluid (PMCF)

Effect of orthodontic forces on cytokine and receptor levels in gingival crevicular fluid: a systematic review

Force-induced increased osteogenesis enables accelerated orthodontic tooth movement in ovariectomized rats

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