Effect of ovarian hormones upon liver mitochondrial function in diabetic rats

Brignone, J.A.; Brignone, C.M.C. de; Rodríguez, Rosalía; Marzi, A; Mignone, I.R; Susemihl, M. C.

doi:10.1016/s0168-8227(88)80026-3

Cited by 4 publications

(8 citation statements)

References 30 publications

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“…Analysis of variance: • P < 0.001 compared with the intact diabetic group. This and OD * Eol groups showed the same alterations we have seen before (Brignone et al 1988).…”

Section: Decreasing Of the Damping Factor Of The Oscillatory Mechanissupporting

confidence: 86%

“…Then the estrogens would potentiate the diabetic mitochondrial alteration since the treatment with TAM or the oophorectomy improved significantly the respiration and the oscillatory behaviour of intact mitochondria (Table 1 and Figure 1) and the activities of HBD and Cox enzymes of disrupted organelles (Table 2). Besides these we have shown previously that the restitution of 17p-estradiol to ovariectomized diabetic rats restored the respiration and the oscillatory behaviour of liver mitochondria to similar values of those observed in intact female diabetic rats (Brignone et al 1988). These data would indicate that the ovariectomy or the treatment with TAM of diabetic female rats provoked a better operating oxidoreduction system in the inner membrane.…”

Section: Discussionsupporting

confidence: 75%

“…In a previous work, we have demonstrated that chronic diabetes impaired hepatic mitochondrial function and altered certain enzyme activities of the organella (Brignone, Brignone de, Rodriguez, Badano and Stoppani 1982). In addition, we showed that diabetic alterations of some parameters of mitochondrial function in the liver of female diabetic rats were reverted partially or totally by ovariectomy (Brignone, Brignone de, Rodriguez, Marzi, Mignone de and Susemihl 1988). The restitution of 17B-estradiol restored these parameters to values similar to those of the intact diabetic animals.…”

Section: Introductionmentioning

confidence: 54%

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Improving Effects Obtained by the Ovariectomy or Treatment with Tamoxifen of Female Diabetic Rats over the Function and Enzyme Activities of Liver Mitochondria

Brignone

Brignone²,

Mignone³

et al. 1991

Horm Metab Res

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In the present work we studied, in female chronic diabetic rats the effect of either the parenteral administration of tamoxifen (TAM) (500 micrograms.kg-1.day-1) for 15 days or the ovariectomy upon the respiration and oscillatory behaviour of intact mitochondria and the activities of 3-hydroxybutyrate dehydrogenase (HBD) and cytochrome c oxidase (Cox) of disrupted liver mitochondria. The treatment with TAM as well as the ovariectomy of diabetic animals significantly increased the respiratory control (RC) and the state 3 (S3) of respiration of intact liver mitochondria with the three substrates assayed (3-hydroxybutyrate, malate-glutamate and succinate). Both treatments also lowered significantly the damped factors of the oscillatory variation of liver intact mitochondria of diabetic rats. Moreover, the two above-mentioned treatments restored the activities of HBD and Cox of liver disrupted mitochondria to normal values. The effect of estrogens at level of its receptors in the modulation of liver mitochondrial function and liver HBD and Cox activities in chronic diabetes is discussed.

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“…Analysis of variance: • P < 0.001 compared with the intact diabetic group. This and OD * Eol groups showed the same alterations we have seen before (Brignone et al 1988).…”

Section: Decreasing Of the Damping Factor Of The Oscillatory Mechanissupporting

confidence: 86%

Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 54%

See 1 more Smart Citation

Improving Effects Obtained by the Ovariectomy or Treatment with Tamoxifen of Female Diabetic Rats over the Function and Enzyme Activities of Liver Mitochondria

Brignone

Brignone²,

Mignone³

et al. 1991

Horm Metab Res

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“…183,184 STZ-induced chronic diabetes in female albino rats produced signicant alterations in liver mitochondrial function which included a signicant fall of the mean values of the respiratory control ratio and of state 3 of respiration using three substrates, 3-hydroxybutyrate, malate-glutamate and succinate, and a signicant increase of the mean damping factor of the oscillatory osmotic variations (with valinomycin as the K + ionophore and succinate as the substrate). 183 The oophorectomized STZ diabetic rats showed signicantly higher values of the respiratory control ratio and of state 3 of respiration and signicantly lower damping factors than female rats with chronic diabetes. 183 The restitution treatment in the oophorectomized rats with restitution therapy of 17-beta-estradiol restored the mitochondrial functions assayed to values similar to female rats with chronic diabetes.…”

Section: (B) Beta Estradiolmentioning

confidence: 99%

The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver

2013

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Several antioxidants and agents having similar antioxidant effects are known to exert beneficial effects in ameliorating the injurious effects of hyperglycemia on liver in different diabetic in vitro and in vivo models. The review deals with some of the agents which have been shown to exert protective effects on liver against hyperglycemic insult and the various mechanisms involved. The different classes of agents which protect the diabetic liver or decrease the severity of hyperglycemia mediated injury include flavonoids, catechins, and other polyphenolic compounds, curcumin and its derivatives, certain vitamins, hormones and drugs, trace elements, prototypical antioxidants and amino acids. Some of the pronounced changes mediated by the antioxidants in liver exposed to hyperglycemia include decreased oxidative stress, and alterations in carbohydrate and lipid metabolism. Other mechanisms through which the agents ameliorate hyperglycemia mediated liver injury include decrease in oxidative DNA and protein damage, restoration of mitochondrial structural and functional integrity, decrease in inflammation and improved insulin signaling. Thus, antioxidants may prove to be an important mode of defense in maintaining normal hepatic functions in diabetes.

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“…Oophorectomy of diabetic rats significantly improved all the parameters measured to assess mitochondrial function, while administration of 17‐ β estradiol to these rats restored the diabetic alterations of the mitochondrial function158. Furthermore, treatment of intact diabetic animals with tamoxifen (an estrogen antagonist) reproduced the ameliorating effect of oophorectomy upon the impaired liver mitochondrial function159–163. Similarly, bilateral adrenalectomy of diabetic rats or their treatment with a specific glucocorticoid antagonist (RU 38486) produced significant improvement of mitochondrial function.…”

Section: Basic Researchmentioning

confidence: 95%

An overview of Argentine contributions to diabetes research in the decade of the 1990s

Gagliardino

2000

Diabetes Metab. Res. Rev.

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Argentina has a longstanding tradition of diabetes research, beginning with the seminal work of Prof. Bernardo A. Houssay, who was awarded the first Nobel Prize in Medical Sciences for his studies on the relationship between diabetes and pituitary function. Prof. Luis F. Leloir, who was also awarded the Nobel Prize for his work in carbohydrate metabolism, also inspired younger generations of biologists to work in the field of diabetes research. The aim of this paper is to provide a review of the contributions of Argentine researchers during the 1990s. This manuscript includes only reports of Argentine researchers working on diabetes in local laboratories and quoted in Medline. Thus, important contributions not reported in journals included in Medline or produced by Argentine researchers working abroad may have been omitted. The material consists of a brief description of clinical research (epidemiology and costs, metabolic control, associated risk factors, immunological aspects, and other clinical studies) and basic research (animal model with spontaneous diabetes, islet morphology and function in normal and pathological conditions, insulin action, metabolic disorders related to diabetes, and some miscellaneous effects related to drug‐induced diabetes). Altogether, a broad idea of the continuous contribution of our national research to the international field of diabetes is provided, as well as a list of Argentine researchers and research centers devoted to the study of diabetes. Copyright © 2000 John Wiley & Sons, Ltd.

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Effect of ovarian hormones upon liver mitochondrial function in diabetic rats

Cited by 4 publications

References 30 publications

Improving Effects Obtained by the Ovariectomy or Treatment with Tamoxifen of Female Diabetic Rats over the Function and Enzyme Activities of Liver Mitochondria

Improving Effects Obtained by the Ovariectomy or Treatment with Tamoxifen of Female Diabetic Rats over the Function and Enzyme Activities of Liver Mitochondria

The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver

An overview of Argentine contributions to diabetes research in the decade of the 1990s

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