Effect of ovarian steroids on migration of uterine lumenal neutrophils and on chemokinetic factors in uterine secretions from mares

Watson, E.D.

doi:10.1111/j.2042-3306.1988.tb01547.x

Cited by 8 publications

(3 citation statements)

References 10 publications

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“…Alterations in the hormonal levels may predispose mares, cows and rats to uterine infection (Hawk et al 1961;Hawk et al 1964;Ganjam et al 1982;Nishikawa and Baba 1985a;Nishikawa 1985). Ovarian hormones have also been shown to influence bacterial adhesion to the mucosa, which is the first step to infection (Nishikawa and Baba 1985b;Maslow et al 1988;Watson 1988). In the mare, bacterial attachment to endometrium with high degree of fibrosis was reported to be higher during oestrus (Ferreira-Dias et al 1994).…”

Section: Introductionmentioning

confidence: 99%

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Peripheral Blood Neutrophil Function and Lymphocyte Subpopulations in Cycling Mares

Costa¹,

Carvalho²,

Agricola³

et al. 2003

Reprod Domestic Animals

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The purpose of this study was to evaluate different parameters of the immune status in the mare, during the follicular and the luteal phases of the oestrous cycle, in two consecutive years. Functional competence of peripheral blood neutrophils, such as chemotaxis, phagocytosis and oxidative burst was assessed under physiological cyclic conditions (Exp. I). In the second year of this study (Exp. II), besides peripheral blood neutrophil phagocytosis and oxidative burst analysis, circulating lymphocyte subsets were also characterized. The reproductive status in a total of 17 adult cycling mares was evaluated by ultrasonography and further confirmed by plasma progesterone levels. Chemotaxis tests were performed using porous membranes inserted in transwell chambers. Lipopolysaccharide (LPS) from Escherichia coli and N-formyl-Met-Leu-Phe (fMLP) were used as chemoattractants. Measurement of phagocytosis and oxidative burst in blood neutrophils were assessed by flow cytometry using commercially available kits. Quantification of T-lymphocyte subsets was assessed by indirect immunofluorescence staining after incubation with monoclonal antibodies specific for CD2, CD3, CD4 and CD8 cell markers by flow cytometry. Natural killer cells and B cells were estimated mathematically. No significant difference was found in migration, phagocytosis and oxidative burst at either phase of the oestrous cycle. Statistical analysis of total white blood cell counts also showed no significant difference between either phase of the oestrous cycle, although there was a tendency for blood neutrophils to increase in number under the progesterone influence (p = 0.09). Lymphocytic subpopulations did not differ throughout the oestrous cycle. Overall, our results suggest that luteal and follicular phases in cycling mares may not influence the immune status of the mare.

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Section: Introductionmentioning

confidence: 99%

“…Ovarian hormones have also been shown to influence bacterial adhesion to the mucosa, which is the first step to infection (Nishikawa and Baba 1985b; Maslow et al. 1988; Watson 1988). In the mare, bacterial attachment to endometrium with high degree of fibrosis was reported to be higher during oestrus (Ferreira‐Dias et al.…”

Section: Introductionmentioning

confidence: 99%

Peripheral Blood Neutrophil Function and Lymphocyte Subpopulations in Cycling Mares

Costa¹,

Carvalho²,

Agricola³

et al. 2003

Reprod Domestic Animals

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“…A complex relationship between the reproductive steroid hormone levels and immune system has been described [ 24 ], and the susceptibility of the uterus to infection reportedly increases during the luteal phase of the estrous cycle in rabbits [ 2 ] and cows [ 28 ]. Ovarian hormones influence bacterial adhesion to the mucosa, which is the first step of infection [ 38 ]. Few reports are available regarding hematological changes and estrous cycles in farm animals.…”

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confidence: 99%

Long-term monitoring of circulating progesterone and its relationship to peripheral white blood cells in female false killer whales <i>Pseudorca crassidens</i>

Funasaka

Yoshioka

Koga

et al. 2018

The Journal of Veterinary Medical Science

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Long-term monitoring of circulating progesterone levels in three captive female false killer whales, Pseudorca crassidens, was conducted to characterize their reproductive events and to reveal the relationship between their estrous cycles or pregnancies and peripheral white blood cell (WBC) counts. Blood samples were collected at 2–3-day intervals or on a weekly-to-monthly basis for up to 10 years, from 2006 to 2017. In two mature females (initial body lengths of 4.22 and 4.07 m), some cyclic progesterone elevations were detected during the study period; the estimated mean (± SE) estrous cycle length was 40.5 ± 0.7 days (n=12). The seasonality of ovulation, estimated from the elevation of progesterone levels, varied among individuals or years, and ovulation did not occur every year. The third female (3.26 m) showed progesterone elevations, despite irregular cycles after sexual maturity, and became pregnant. The progesterone levels during pregnancy ranged from 7.3 to 42.2 ng/ml, and the gestation period lasted for 14 months until parturition. The mean WBC counts during estrous cycles were the lowest before the progesterone levels began to increase and then gradually increased toward the luteal phase. The WBC counts were significantly higher during pregnancy than before and were particularly high in early pregnancy. To the best of our knowledge, this is the first report of the relationship between the estrous cycle or pregnancy and WBC counts in cetaceans.

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Making sense of equine uterine infections: The many faces of physical clearance

Causey

2006

The Veterinary Journal

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Effect of ovarian steroids on migration of uterine lumenal neutrophils and on chemokinetic factors in uterine secretions from mares

Cited by 8 publications

References 10 publications

Peripheral Blood Neutrophil Function and Lymphocyte Subpopulations in Cycling Mares

Peripheral Blood Neutrophil Function and Lymphocyte Subpopulations in Cycling Mares

Long-term monitoring of circulating progesterone and its relationship to peripheral white blood cells in female false killer whales <i>Pseudorca crassidens</i>

Making sense of equine uterine infections: The many faces of physical clearance

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