Effect of Ovary Lipid from Skipjack Tuna (Katsuwonus pelamis) on Brain Monoamines in Rats

Abstract

In our previous experiments with rats, ovary lipid from Skipjack Tuna (Katsuwonus pelamis) (OLS) was shown to have a mitigating effect on anxiety and/or fear in elevated T-maze tests. This suggests that OLS has some effect on the central nervous system (CNS) of rats. Thus, we performed experiments to examine the status of CNS in rats given OLS. The effect of OLS on chronic stress was also examined at the same time. The feed for control rats used oil and fat that have the same energy percentages for n-6 and n-3 fatty acids and the same n-6/n-3 ratio as OLS. As a result, rats given OLS for 28 days had lower serotonin levels in various brain areas regardless of stress application, showing that OLS affected the serotonin nervous system. From this, it was inferred that the ability of OLS to mitigate anxiety and/or fear resulted from its action on CNS, especially the serotonin nervous system. Substances other than the essential fatty acids may have been responsible for the action of OLS on monoamines and the metabolites. The effect of OLS on CNS, especially the serotonin nervous system, suggests that OLS may suppress anxiety.

Twelve Antioxidant Peptides From Protein Hydrolysate of Skipjack Tuna (Katsuwonus pelamis) Roe Prepared by Flavourzyme: Purification, Sequence Identification, and Activity Evaluation

“…Skipjack tuna (Katsuwonus pelamis) is the main resource of canned fish and shares of more than 70% of tuna catches (3,26,27). Many researches have utilized by-products of skipjack tuna to produce some functional components, such as collagens and gelatins (28,29), BPs (9,21,30), oil and lipid (11,31), and multiple sulfated polysaccharides (32). Roe is one of the main by-products of skipjack tuna and is rich in crude proteins with the content of 21.00 ± 0.06% of tuna roe (on a wet weight basis) (33).…”