Effect of oxidation on Ca2+-ATPase activity and membrane lipids in lens epithelial microsomes

Ahuja, R.P; Borchman, Douglas; Dean, William L.; Paterson, Christopher A.; Zeng, Junwen; Zhang, Z; Ferguson-Yankey, Stacey R.; Yappert, Marta C.

doi:10.1016/s0891-5849(99)00068-4

Cited by 37 publications

(18 citation statements)

References 50 publications

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“…The major lipids of the SR membrane are PCs, PEs and phosphatidylinositols (Krainev et al 1995;Dalton et al 1998). The activity of ATPase is dependent on the chemical structure and physical phase of its surrounding phospholipids (Dalton et al 1998;Lee 1998;Ahuja et al 1999;Karlovska et al 2006Karlovska et al , 2007. For example, high ratios of ω-6 to ω-3 polyunsaturated fatty acids increase the activity of SERCA in the SR of the heart (Ruf and Arnold 2008).…”

Section: Discussionmentioning

confidence: 99%

Oxidative injury induced by hypochlorous acid to Ca-ATPase from sarcoplasmic reticulum of skeletal muscle and protective effect of trolox

Štrosová

Karlovska²,

Spickett

et al. 2009

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Abstract. Hypochlorous acid (HOCl) concentration-dependently decreased ATPase activity and SH groups of pure Ca-ATPase from sarcoplasmic reticulum (SERCA) of rabbit skeletal muscle with IC 50 of 150 µmol/l and 6.6 µmol/l, respectively. This indicates that SH goups were not critical for impairment of Ca-ATPase activity. Pure Ca-ATPase activity was analysed individually with respect to both substrates, Ca 2+

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Section: Discussionmentioning

confidence: 99%

Oxidative injury induced by hypochlorous acid to Ca-ATPase from sarcoplasmic reticulum of skeletal muscle and protective effect of trolox

Štrosová

Karlovska²,

Spickett

et al. 2009

gpb

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“…Neuronal iron deposition causes oxidative stress via the Fenton reaction, which might contribute to elevated oxidative stress observed in the AD brain [109]. Iron-induced oxidative stress has been shown to initiate several apoptotic signaling pathways in neurons [110], and damage proteins such as Ca 2+ -ATPase [111][112][113][114], glutamate transporter [115][116][117], apolipoprotein E [118,119], and Na + /K + -ATPase [111,114,120,121], as well as N-methyl-D-aspartate (NMDA) receptor [122][123][124], and lipids such as cholesterol [125][126][127], ceramides [128,129], and unsaturated fatty acids [130][131][132][133], as well as sphingomyelin [134,135]. Oxidative damage to proteins and lipids by iron can cause synaptic dysfunction and neuronal cell death [136].…”

Section: Ironmentioning

confidence: 99%

Biometals and Their Therapeutic Implications in Alzheimer's Disease

2015

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No disease modifying therapy exists for Alzheimer's disease (AD). The growing burden of this disease to our society necessitates continued investment in drug development. Over the last decade, multiple phase 3 clinical trials testing drugs that were designed to target established disease mechanisms of AD have all failed to benefit patients. There is, therefore, a need for new treatment strategies. Changes to the transition metals, zinc, copper, and iron, in AD impact on the molecular mechanisms of disease, and targeting these metals might be an alternative approach to treat the disease. Here we review how metals feature in molecular mechanisms of AD, and we describe preclinical and clinical data that demonstrate the potential for metal-based drug therapy.

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“…For the fillets pretreated with YAP, the decrease in ATPase activity along with the storage time was significantly (P < 0.05) retarded from Day 0 to Day 4, and this retarding effect showed a concentration-dependent relationship. As the fact that lipid oxidation is one important factor affecting the ATPase activity (Ahuja, Borchman, & Dean, 1999;Thanonkaew, Benjakul, Visessanguan, & Decker, 2006), and that YAP was shown to retard the fish lipid oxidation process (Table 3), the protective effect on ATPase activity by YAP may also be attributed to its antioxidation property.…”

Section: Effect Of Yap On Atpase Activitymentioning

confidence: 99%

Antioxidant activities of young apple polyphenols and its preservative effects on lipids and proteins in grass carp (Ctenopharyngodon idellus) fillets

Sun

Meng

et al. 2016

CyTA - Journal of Food

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The aim of this study was to study the antioxidant and antibacterial activities of young apple polyphenols (YAP) and to investigate the application of YAP in grass carp fillets (GCF) stored at 4°C for retarding lipid and protein degradation. The results indicated that YAP had high antioxidant activities in vitro, and the addition of YAP to GCF during low-temperature storage could significantly inhibit the microbial growth; retard the decrease in contents of fatty acids for both unsaturated and saturated ones; and minimize the degradation of salt-soluble myofibrillar protein and sulfhydryl group. The profiles of GCF in the presence and absence of YAP under a scanning electron microscope indicated that YAP could protect GCF from destruction that was resulted from fish deterioration. Therefore, YAP may be developed as natural antioxidants to control lipid and protein degradation and to extend shelf life of freshwater fish fillets.Actividades antioxidantes de polifenoles de manzanas verdes y sus efectos conservantes en los lípidos y las proteínas de filetes de carpa herbívora (Ctenopharyngodon idellus) RESUMEN El objetivo de este trabajo fue estudiar las actividades antioxidantes y antibacterianas de los polifenoles de manzanas verdes (YAP) e investigar la aplicación de YAP en los filetes de carpa herbívora (GCF) almacenados a 4°C para retardar la degradación lipídica y proteínica. Los resultados indicaron que YAP tenían una actividad antioxidante in vitro alta, además la adición de YAP a GCF durante el almacenamiento a baja temperatura podría inhibir significativamente el crecimiento microbiano, retardar la disminución de los contenidos de ácidos grasos insaturados y saturados, además de minimizar la degradación de la proteína miofibrilar soluble en sal y el grupo sulfhídrico. Los perfiles de GCF en presencia y ausencia de YAP bajo microscopio electrónico de barrido indicaron que YAP podría proteger a GCF de la destrucción debida a la deterioración del pescado. Por lo tanto, YAP podrían ser desarrollados como antioxidantes naturales para controlar la degradación lipídica y proteínica, además de extender el tiempo de almacenamiento de los filetes de pescado de agua dulce. ARTICLE HISTORY

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Effect of oxidation on Ca2+-ATPase activity and membrane lipids in lens epithelial microsomes

Cited by 37 publications

References 50 publications

Oxidative injury induced by hypochlorous acid to Ca-ATPase from sarcoplasmic reticulum of skeletal muscle and protective effect of trolox

Oxidative injury induced by hypochlorous acid to Ca-ATPase from sarcoplasmic reticulum of skeletal muscle and protective effect of trolox

Biometals and Their Therapeutic Implications in Alzheimer's Disease

Antioxidant activities of young apple polyphenols and its preservative effects on lipids and proteins in grass carp (Ctenopharyngodon idellus) fillets

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