Effect of oxidative stress on fluoride-induced apoptosis in primary cultured Sertoli cells of rats

Yang, Yang; Huang, Hui; Ba, Yue; Cheng, Xuemin; Cui, Liuxin

doi:10.1080/09603123.2014.883595

Cited by 27 publications

(13 citation statements)

References 21 publications

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“…Our previous studies documented fluoride-induced oxidative damage and pathological injury in liver [ 10 , 11 ], kidney [ 12 ], and intestine [ 13 - 16 ] in broiler chickens. Fluoride can induce oxidative damage, apoptosis and DNA damage in human osteosarcoma cells and in rat sertoli cells [ 17 , 18 ]. In recent years, more studies have focused on the effect of fluorine on the immune system.…”

Section: Introductionmentioning

confidence: 99%

Effects of sodium fluoride on blood cellular and humoral immunity in mice

et al. 2017

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Exposure to high fluorine can cause toxicity in human and animals. Currently, there are no systematic studies on effects of high fluorine on blood cellular immunity and humoral immunity in mice. We evaluated the alterations of blood cellular immunity and humoral immunity in mice by using flow cytometry and ELISA. In the cellular immunity, we found that sodium fluoride (NaF) in excess of 12 mg/Kg resulted in a significant decrease in the percentages of CD3+, CD3+CD4+, CD3+CD8+ T lymphocytes in the peripheral blood. Meanwhile, serum T helper type 1 (Th1) cytokines including interleukin (IL)-2, interferon (IFN)-γ, tumor necrosis factor (TNF), and Th2 cytokines including IL-4, IL-6, IL-10, and Th17 cytokine (IL-17A) contents were decreased. In the humoral immunity, NaF reduced the peripheral blood percentages of CD19+ B lymphocytes and serum immunoglobulin A (IgA), immunoglobulin G (IgG) and immunoglobulin M (IgM). The above results show that NaF can reduce blood cellular and humoral immune function in mice, providing an excellent animal model for clinical studies on immunotoxicity-related fluorosis.

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Section: Introductionmentioning

confidence: 99%

Effects of sodium fluoride on blood cellular and humoral immunity in mice

et al. 2017

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“…Plants react to soil and air pollution, urbanization, weather and environmental conditions, which can influence the pollen allergenicity (Lázaro et al 2014 ; Todea et al 2013 ; Koenig and Tabb 1980 ). The pollen collection sites exhibited different concentration and type of air pollutants and degree of urbanization.…”

Section: Discussionmentioning

confidence: 99%

“…This period coincides with the heating season in Central Europe, when increased levels of contaminants such as SO 2 , NO 2 , CO 2 and O 3 are observed. Numerous studies correlating the increase in number of people suffering from allergy with morphological and biochemical changes within the pollen grain caused by air pollutants have been conducted (Emberlin et al 1993 ; D’Amato 2000 ; Ackaert et al 2014 ; Lázaro et al 2014 ; Todea et al 2013 ). These changes can cause a more frequent occurrence of inhalant allergies or more severe allergic reactions (Pasqualini et al 2015 ; Tedeschini et al 2015 ).…”

Section: Introductionmentioning

confidence: 99%

FTIR analysis of molecular composition changes in hazel pollen from unpolluted and urbanized areas

et al. 2016

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In this study, the effect of urbanization and environmental pollution on qualitative (structural) and quantitative changes of the Corylus avellana (hazel) pollen was investigated using scanning electron microscopy, Fourier Transform Infrared (FTIR) spectroscopy and curve-fitting analysis of amide I profile. The obtained spectroscopic results show significant variations in the fraction of proteins in the hazel pollen, which probably depend on various degrees of anthropopression. Our results suggest that alterations in the chemical composition of pollen, induced by urbanization and air pollutants, may intensify the allergenic potential and may cause the increase in the incidence of allergies in people. Mutations in nucleic acids are accompanied by a number of molecular changes leading to the formation of allergenic proteins. It seems that the type of habitat, where the pollen grew, affects the individual differentiation. Indeed, it was found that in the site exhibiting low pollution, the hazel pollen contain a lower amount of proteins than to the ones from a site with high anthropopression. Hence, FTIR spectroscopy and curve-fitting analysis of amide I profile can be successfully applied as tools for identifying quantitative and qualitative changes of proteins in hazel pollen.Graphical Abstract Anthropogenic factors such as air pollution and urbanization lead to changes in structure and chemical composition of hazel pollen. Fourier Transform Infrared spectroscopy (FTIR) and Gaussian analysis showed structural changes in hazel pollen collected from sites with different absorbance values of individual chemical functional groups and changes in the secondary structure of proteins of the pollen.

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“…Reproductive cells. When Sertoli cells were exposed do fluoride in vitro, endoplasmic reticulum stress, decreased cell viability and apoptosis was detected at varying doses (58).…”

Section: In Vitro Studiesmentioning

confidence: 99%

“…The endoplasmic stress as evidenced by up-regulated glucose-regulated protein 78 kDa (GRP78), PKR-like ER kinase (PERK), phosphorylation of eukaryotic translation initiation factor 2α (p-eIF2α) and CCAAT/enhancer-binding protein-homologous protein (CHOP), without affecting total eukaryotic translation initiation factor 2α (eIF2α) (59). In addition, NaF facilitated the accumulation of ROS and increased nuclear translocation of nuclear factor erythroid 2related factor 2 (Nrf2) in Sertoli cells (58,59). The levels of FasL protein and mRNA decreased with the increase of fluoride concentration in mouse sertoli cells (60).…”

Section: In Vitro Studiesmentioning

confidence: 99%

Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies

Ribeiro

Cardoso

Yujra

et al. 2017

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Apoptosis is genetically programmed cell death, an irreversible process of cell senescence with characteristic features different from other cellular mechanisms of death such as necrosis. In the last years, apoptosis has been extensively studied in the scientific literature, because it has been established that apoptosis plays a crucial role following the time course of chronic degenerative diseases, such as cancer. Thus, several researchers have strugged to detect what chemical agents are able to inter fere with the apoptotic process. Thus, the purpose of this literature review is to assess if fluoride induces apoptosis in mammalian cells using in vivo and in vitro test systems. Certain mammalian cell types such as oral cells, blood and brain were exetensively investigated; the results showed that fluoride is able to induce apoptosis in both intrinsinc and extrinsic pathways. Moreover, other cells types have been poorly investigated such as bone, kidney and reproductive cells with conflicting results so far. Therefore, this area needs further investigation for the safety of human populations exposed to fluoride in a chronic way, as for example in developing countries.

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Effect of oxidative stress on fluoride-induced apoptosis in primary cultured Sertoli cells of rats

Cited by 27 publications

References 21 publications

Effects of sodium fluoride on blood cellular and humoral immunity in mice

Effects of sodium fluoride on blood cellular and humoral immunity in mice

FTIR analysis of molecular composition changes in hazel pollen from unpolluted and urbanized areas

Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies

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