Effect of Oxidative Stress on Membrane Structure: Small-Angle X-Ray Diffraction Analysis

Mason, R. Preston; Walter, Mary; Mason, Pamela E.

doi:10.1016/s0891-5849(97)00101-9

Cited by 109 publications

(66 citation statements)

References 25 publications

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“…The free radicals produced can then react with different cellular components, causing the oxidation of lipids and proteins and DNA damage, and leading eventually to cell death. Lipid peroxidation results in significant changes in the structure and organization of membrane lipids, which can cause further alterations in numerous membrane functions, and consequently, in the functions of different membrane proteins (Mason et al 1997;Vígh et al 2005;Escribá et al 2008). ROS can also denature proteins, which results in changes in protein structure leading to protein aggregation and the loss of enzymatic activity.…”

Section: The Effects Of Alcohol On Cellular Physiologymentioning

confidence: 99%

Alcohol stress, membranes, and chaperones

Tóth

Vı́gh

Sántha

2014

Cell Stress and Chaperones

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Ethanol, which affects all body organs, exerts a number of cytotoxic effects, most of them independent of cell type. Ethanol treatment leads to increased membrane fluidity and to changes in membrane protein composition. It can also interact directly with membrane proteins, causing conformational changes and thereby influencing their function. The cytotoxic action may include an increased level of oxidative stress. Heat shock protein molecular chaperones are ubiquitously expressed evolutionarily conserved proteins which serve as critical regulators of cellular homeostasis. Heat shock proteins can be induced by various forms of stresses such as elevated temperature, alcohol treatment, or ischemia, and they are also upregulated in certain pathological conditions. As heat shock and ethanol stress provoke similar responses, it is likely that heat shock protein activation also has a role in the protection of membranes and other cellular components during alcohol stress.

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Section: The Effects Of Alcohol On Cellular Physiologymentioning

confidence: 99%

Alcohol stress, membranes, and chaperones

Tóth

Vı́gh

Sántha

2014

Cell Stress and Chaperones

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“…Increased oxidation of myofibrilar proteins impacts the function of the contractile system, which might eventually lead to heart failure (reviewed in Bayeva and Ardehali, 2010). In addition, even modest changes in the redox status of membranes are associated with alterations in the molecular organization of the lipid bilayer, affecting the function of integral membrane proteins and disrupting membrane integrity (Mason et al, 1997). Consequently, increases in levels of oxidized proteins and/or lipids in heart ventricles of icefishes in response to exposure to CT max , rather than differences in absolute levels between species, might be problematic for icefishes and contribute to their lower thermal tolerance compared with red-blooded species.…”

Section: Levels Of Oxidized Macromoleculesmentioning

confidence: 99%

Exposure to critical thermal maxima causes oxidative stress in hearts of white- but not red-blooded Antarctic notothenioid fishes

Mueller

Devor

Grim

et al. 2012

Journal of Experimental Biology

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SUMMARYAntarctic icefishes have a significantly lower critical thermal maximum (CT max ) compared with most red-blooded notothenioid fishes. We hypothesized that the lower thermal tolerance of icefishes compared with red-blooded notothenioids may stem from a greater vulnerability to oxidative stress as temperature increases. Oxidative muscles of icefishes have high volume densities of mitochondria, rich in polyunsaturated fatty acids, which can promote the production of reactive oxygen species (ROS). Moreover, icefishes have lower levels of antioxidants compared with red-blooded species. To test our hypothesis, we measured levels of oxidized proteins and lipids, and transcript levels and maximal activities of antioxidants in heart ventricle and oxidative pectoral adductor muscle of icefishes and red-blooded notothenioids held at 0°C and exposed to their CT max . Levels of oxidized proteins and lipids increased in heart ventricle of some icefishes but not in red-blooded species in response to warming, and not in pectoral adductor muscle of any species. Thus, increases in oxidative damage in heart ventricles may contribute to the reduced thermal tolerance of icefishes. Despite an increase in oxidative damage in hearts of icefishes, neither transcript levels nor activities of antioxidants increased, nor did they increase in any tissue of any species in response to exposure to CT max . Rather, transcript levels of the enzyme superoxide dismutase (SOD) decreased in hearts of icefishes and the activity of SOD decreased in hearts of the red-blooded species Gobionotothen gibberifrons. These data suggest that notothenioids may have lost the ability to elevate levels of antioxidants in response to heat stress.

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“…The fatty acyl chains, which elicit the most in¯uence, such as AA, EPA and DHA, contain double bonds, which are exclusively in the cis conformation. The replacement of even a single double bond in these PUFAs is sucient to exert a profound eect on the physical properties of the membrane [28,82]. However, it cannot be taken as axiomatic that there is a simple linear relationship between the physical properties and the number of double bonds.…”

Section: Membrane Structure and Function: Relation To Fatty Acid Pro®lementioning

confidence: 99%

Essential fatty acids and the brain: possible health implications

Youdim

Martín

Joseph

2000

Intl J of Devlp Neuroscience

431

273

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Linoleic and a-linolenic acid are essential for normal cellular function, and act as precursors for the synthesis of longer chained polyunsaturated fatty acids (PUFAs) such as arachidonic (AA), eicosapentaenoic (EPA) and docosahexaenoic acids (DHA), which have been shown to partake in numerous cellular functions aecting membrane¯uidity, membrane enzyme activities and eicosanoid synthesis. The brain is particularly rich in PUFAs such as DHA, and changes in tissue membrane composition of these PUFAs re¯ect that of the dietary source. The decline in structural and functional integrity of this tissue appears to correlate with loss in membrane DHA concentrations. Arachidonic acid, also predominant in this tissue, is a major precursor for the synthesis of eicosanoids, that serve as intracellular or extracellular signals. With aging comes a likely increase in reactive oxygen species and hence a concomitant decline in membrane PUFA concentrations, and with it, cognitive impairment. Neurodegenerative disorders such as Parkinson's and Alzheimer's disease also appear to exhibit membrane loss of PUFAs. Thus it may be that an optimal diet with a balance of n-6 and n-3 fatty acids may help to delay their onset or reduce the insult to brain functions which these diseases elicit. Published by Elsevier Science Ltd.

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Effect of Oxidative Stress on Membrane Structure: Small-Angle X-Ray Diffraction Analysis

Cited by 109 publications

References 25 publications

Alcohol stress, membranes, and chaperones

Alcohol stress, membranes, and chaperones

Exposure to critical thermal maxima causes oxidative stress in hearts of white- but not red-blooded Antarctic notothenioid fishes

Essential fatty acids and the brain: possible health implications

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