Effect of Oxidative Stress on Membrane Proteins in Thalassemia and Iron Deficiency Anemia

Ariyurek, Sedefgul Yuzbasioglu; Aksoy, Kıymet

doi:10.1007/s12098-011-0547-1

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Erythrocyte ghosts were prepared by hypotonic lysis using the method of Dodge et al Solubilized membrane protein samples were analyzed according to the membrane protein profile and molecular weight . SDS-PAGE was performed by the Laemelli method .…”

Section: Methodsmentioning

confidence: 99%

Comparative Study on the Protective Effect of Chlorogenic Acid and 3-(3-Hydroxyphenyl) Propionic Acid against Cadmium-Induced Erythrocyte Cytotoxicity: In Vitro and In Vivo Evaluation

Cheng

Song

Ding

et al. 2021

J. Agric. Food Chem.

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The metabolism of chlorogenic acid (CGA) through the intestinal tract was studied. As cadmium is a well-known toxic heavy metal, this study was carried out to investigate the comparative protective effect of CGA and its representative intestinal metabolite (3-(3-hydroxyphenyl) propionic acid, HPPA) against Cd-induced erythrocyte cytotoxicity in vitro and in vivo. We found that CGA and its intestinal metabolite appreciably prevented erythrocyte hemolysis, osmotic fragility, and oxidative stress induced by Cd. Also, we found that HPPA had a stronger protective ability than CGA against Cd-induced erythrocyte injury in vivo, such as increasing the ratio of protein kinase C from 7.7% (CGA) to 12.0% (HPPA). Therefore, we hypothesized that CGA and its microbial metabolite had protective effects against Cd-induced erythrocyte damage via multiple actions including antioxidation and chelation. For humans, CGA supplementation may be favorable for avoiding Cd-induced biotoxicity.

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Section: Methodsmentioning

confidence: 99%

Comparative Study on the Protective Effect of Chlorogenic Acid and 3-(3-Hydroxyphenyl) Propionic Acid against Cadmium-Induced Erythrocyte Cytotoxicity: In Vitro and In Vivo Evaluation

Cheng

Song

Ding

et al. 2021

J. Agric. Food Chem.

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Significance of malondialdehyde in Iraqi women patients with iron deficiency anemia

Smesim,

Al-Sallami,

Al-janabi

et al. 2024

BIO Web Conf.

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Evidence from previous epidemiological and clinical studies suggests a possible relationship between antioxidant stress and anemia. Our study was conducted from February 2021 to May 2021 and the aim of the study is to evaluate oxidative stress by studying lipid peroxidation for women only in Najaf Governorate / Iraq with iron deficiency anemia compared to healthy controls. A case-control study was designed to evaluate malondialdehyde (MDA). The number of samples was 180, 90 of whom were IDA patients and the other 90 were normal control subjects. Serum levels of Malondialdehyde were assessed using enzyme-linked immunosorbent assay (ELISA). The results showed a stati .stically significant increase in malondialdehyde (MDA) levels (8.54 ± 2.5 (nmol/ml) versus 4.39 ± 0.83 (nmol/ml); P<0.001), in addition to an increase in lipid peroxidation in women with iron deficiency anemia.

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Effect of Oxidative Stress on Membrane Proteins in Thalassemia and Iron Deficiency Anemia

Abstract: Any significant relationship statistically was not found. This consequence may be due to priority removal of oxidatively injured cells from the circulation in thalassemic patients and therefore, significant increase wasn't determined in the concentration of MDA.

Cited by 2 publications

References 23 publications

Comparative Study on the Protective Effect of Chlorogenic Acid and 3-(3-Hydroxyphenyl) Propionic Acid against Cadmium-Induced Erythrocyte Cytotoxicity: In Vitro and In Vivo Evaluation

Comparative Study on the Protective Effect of Chlorogenic Acid and 3-(3-Hydroxyphenyl) Propionic Acid against Cadmium-Induced Erythrocyte Cytotoxicity: In Vitro and In Vivo Evaluation

Significance of malondialdehyde in Iraqi women patients with iron deficiency anemia

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