Effect of Oxidized Soybean Oils on Oxidative Status and Intestinal Barrier Function in Broiler Chickens

Tan, Lulin; Du, Rong; Yang, Ying; Zhang, B

doi:10.1590/1806-9061-2017-0610

Cited by 33 publications

(38 citation statements)

References 47 publications

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“…However, dietary oxidized oil was not able to affect broiler growth during the early growth phase in our study. Similar results were found in the study of Tan et al (2018) . Moderately thermo-oxidized oil did not impair the nutrient digestibility of diet, and there was no significant effect of oxidized oil on digestibility coefficients of crude protein and ether extract ( Açıkgöz et al., 2011 ).…”

Section: Discussionsupporting

confidence: 91%

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Effects of dietary quercetin on the antioxidative status and cecal microbiota in broiler chickens fed with oxidized oil

2020

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This study was conducted to evaluate the effects of quercetin on the antioxidant ability, intestinal barrier functions, and cecal microbiota in broiler chickens fed with oxidized soya oil. Four hundred eighty male Arbor Acres broilers were randomly assigned to 5 treatments, each involving 8 cages (12 birds per cage). The treatment groups were as follows: the control group, birds fed with basal diets containing oxidized oil, and birds fed with basal diets containing oxidized oil and supplemented with 200 ppm of quercetin, 400 ppm of quercetin, and 800 ppm of quercetin. The results showed that dietary supplementation with quercetin at a dose of 400 ppm or 800 ppm alleviated the increased serum malondialdehyde ( MDA ) level induced by oxidized oil on day 11 ( P = 0.005) and reversed the increased MDA level in the mucosa on day 11 ( P = 0.021). Quercetin significantly upregulated the transcription of nuclear factor erythroid 2–related factor 2 ( Nrf2 ) and its downstream genes such as catalase ( P < 0.001), superoxide dismutase 1 ( P < 0.001), glutathione peroxidase 2 ( P = 0.018), heme oxygenase-1 ( HO-1 ) ( P = 0.0), and thioredoxin ( P = 0.002) and reversed the mRNA expression of HO-1 ( P = 0.007) in the ileal mucosa. Tight junction protein 1 was only downregulated by oxidized oil ( P = 0.013). In addition, quercetin (800 ppm) alleviated the decreased mRNA expression of mucin 2 ( MUC2 ), which contributed to the intestinal chemical barrier ( P = 0.039). The supplemental dose of 400 ppm of quercetin was able to promote Lactobacillus in the cecum, which enhanced the gastrointestinal tract health. In summary, these results indicated that quercetin ameliorated the oxidized oil–induced oxidative stress by upregulating the transcription of Nrf2 and its downstream genes to restore redox balance and reinforced the intestinal barrier via higher expression and secretion of MUC2 and facilitating the growth of Lactobacillus in the cecum. Therefore, quercetin could be a potential feed additive that can be applied in poultry production for amelioration of oxidative stress caused by oxidized oil and preventing the potential invasion of exogenous pathogens.

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Section: Discussionsupporting

confidence: 91%

“…Oil is commonly used in poultry feed to meet the energy requirement, especially during summer to alleviate acute heat stress ( Tan et al., 2018 ). However, high contents of unsaturated fatty acids in soybean oils make them prone to oxidation in hot climates.…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary quercetin on the antioxidative status and cecal microbiota in broiler chickens fed with oxidized oil

2020

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“…These results are consistent with the study by Leskovec et al (2018), who found that the broilers exposed to the oxidative stress were induced by a high n À 3 dietary polyunsaturated fatty acids showed the higher MDA contents in breast muscle and lower whole blood GPx activity. Also, similar results have been found in other studies (Tavarez et al 2011;Delles et al 2014;Liang et al 2015;Tan et al 2018;Lindblom et al 2019). Our results regarding the effects of dietary WS on the antioxidant indices are in line with the previous findings of Khalil et al (2015), who showed that oral pre-treatment of the rats with WS leaf extract (100 mg/kg BW) for 4 weeks alleviated the oxidative stress induced by the isoproterenol via reducing the MDA levels and elevating the SOD and GPx activities in the heart tissues.…”

Section: Discussionsupporting

confidence: 93%

“…These results are consistent with a previous study of Tan et al (2019), who reported that the dietary supplementation of the oxidised fish oil did not influence the morphology of the small intestine. It has also been demonstrated that the dietary oxidised soybean oil did not influence the morphological characteristics of the jejunum and ileum (Tan et al 2018).…”

Section: Discussionmentioning

confidence: 98%

Hydroalcoholic extract of Withania somnifera leaf and α-tocopherol acetate in diets containing oxidised oil: effects on growth performance, immune response, and oxidative status in broiler chickens

Azimi¹,

Mirakzehi²,

Saleh³

2020

Italian Journal of Animal Science

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This study was conducted to evaluate the effects of hydroalcoholic leaf extract of Withania somnifera (WS) and a-tocopherol acetate (a-Toc) in the diets containing oxidised oil on the growth performance, immune response, and oxidative status in the broiler chickens. A 3-way factorial design (2 Â 3 Â 2) was applied consisting of the oxidised oil (0 and 2%), WS (0, 100 and 200 mg/ kg diet), and a-Toc (0 and 200 mg/kg). In total, 600 one-day-old male broilers were randomly subjected to 12 treatments with 5 replicates (10 birds/replicate). Broilers were provided with feed and water ad libitum during the 42-day experimental period. On day 42, one bird per each replicate was killed to measure the lymphoid organ weights, intestinal morphometric parameters, and MDA content in the thigh meat. Dietary oxidised oil reduced the FI, and BWG (p < .05). In contrast, dietary WS at a concentration of 200 mg/kg alleviated the negative effects of the oxidised oil on the BWG. Birds fed with the dietary oxidised oil revealed lower titres of antibody against the SRBC (p < .05). Antibody titres were significantly increased by the supplementary WS (p < .05), except for IgG, and IgM during primary and secondary responses, respectively. Dietary supplementation of WS at the concentrations of 100 or 200 mg/kg resulted in a higher CBH response after 12 h (p < .01). Birds fed with the diet supplemented with WS exhibited significantly higher spleen weight than those fed with the non-WS-supplemented diets (p < .01). Dietary oxidised oil significantly increased the MDA content in thigh meat, and inversely reduced the activity of serum antioxidant enzymes (p < .05). Birds fed with the WS-supplemented diets showed significantly lower levels of MDA content in thigh meat, and conversely higher values of serum GPx and SOD activities (p < .05). The GPx activity values were significantly higher for the birds fed with the dietary a-Toc compared to those fed with the nona-Toc-supplemented diets (p < .05). Our findings showed that the presence of WS in the broilers diets as an alternative to a-Toc could be a good approach to improve the performance, immune response, and meat oxidative stability under oxidative stress conditions. HIGHLIGHTS Dietary oxidised oil reduced the FI, and BWG, and the diets supplemented with WS leaf extract alleviated the deleterious effects of the oxidised oil on the BWG. Dietary WS revealed the immunostimulatory effects. The birds fed with the WS-supplemented diets showed a higher antibody titre against the SRBC. Dietary inclusion of WS in the broilers diets negated the negative effects of the oxidised oil by reducing the MDA content in thigh meat and increasing the activity of the antioxidant enzymes.

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“…However, polyunsaturated fatty acids are highly sensitive towards oxidation during storage that could be detrimental for the growth and health of broilers (Jakobsen et al, 1993;Engberg et al, 1996;Anjum et al, 2004;Tan et al, 2018;Yang et al, 2019). A lot of work has been done to evaluate the effect of oxidized oil on the broiler production, however, the results of oxidized oils on the broilers production are conflicting (Jakobsen et al, 1993;Engberg et al, 1996;Anjum et al, 2004;Tan et al, 2018;Tan et al, 2018). Oertel & Hartfiel (1982) reported that the addition of oxidized soybean oil @ 7% in the diet of broilers had no effect on feed intake, weight gain, and feed conversion ratio of growing broilers.…”

Section: Introductionmentioning

confidence: 99%

Effect of Fat Sources and Emulsifier Supplementation in Broiler Starter, Grower and Finisher Diets on Performance, Nutrient Digestibility, and Carcass Parameters

Jamil

Mehmood

Rahman

et al. 2020

Braz. J. Poult. Sci.

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The purpose of this study was to evaluate the effect of fat sources and emulsifier supplementation in different phases on growth performance of broilers. Treatments were; (T1) basal ration (BR) which contained soy oil (SO) and had inclusion of emulsifier for whole life, (T2) BR which contained poultry fat (PO) and had inclusion of emulsifier for whole life, (T3) BR which contained oxidized oil (OO) and had inclusion of emulsifier for whole life, (T4) BR which contained SO and had inclusion of emulsifier during starter phase (T5) BR which contained PO and had inclusion of emulsifier during the starter phase, (T6) BR which contained OO and had inclusion of emulsifier during the starter phase, (T7) BR which contained SO and had inclusion of emulsifier during the starter phase (T8) BR which contained PO and had inclusion of emulsifier during the grower phase, (T9) BR which contained OO and had inclusion of emulsifier during the grower phase, (T10) BR which contained SO and had inclusion of emulsifier during the finisher phase, (T11) BR which contained PO and had inclusion of emulsifier during the finisher phase (T12) BR which contained OO and had inclusion of emulsifier during the finisher phase. The Basal ration which contained SO and supplemented emulsifier during the grower phase and throughout life increased the body weight gain. The supplementation of emulsifier in the finisher phase and throughout life in a diet which contained SO had better feed conversion ratio. The supplementation of emulsifier in the finisher phase and throughout life in SO based diet increased the dry matter and crude fat digestibility. We recommend emulsifier supplementation in the finisher phase for the economic point of view.

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Effect of Oxidized Soybean Oils on Oxidative Status and Intestinal Barrier Function in Broiler Chickens

Cited by 33 publications

References 47 publications

Effects of dietary quercetin on the antioxidative status and cecal microbiota in broiler chickens fed with oxidized oil

Effects of dietary quercetin on the antioxidative status and cecal microbiota in broiler chickens fed with oxidized oil

Hydroalcoholic extract of Withania somnifera leaf and α-tocopherol acetate in diets containing oxidised oil: effects on growth performance, immune response, and oxidative status in broiler chickens

Effect of Fat Sources and Emulsifier Supplementation in Broiler Starter, Grower and Finisher Diets on Performance, Nutrient Digestibility, and Carcass Parameters

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