Effect of ozone pretreatment on characteristics of dissolved organic matter formed in aerobic and anaerobic digestion of waste-activated sludge

Du, Haixia; Wu, Yifan; Wu, Haixia; Li, Fusheng

doi:10.1007/s11356-020-10596-4

Cited by 15 publications

(3 citation statements)

References 36 publications

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“…Protein UV absorbance comes mainly from the aromatic residues tryptophan and tyrosine. 39 The binding site of PSI-697 and THCMA on P-selectin is surrounded by multiple tyrosine residues: Tyr5, Tyr10, Tyr18, Tyr44, Tyr45, Tyr48, Tyr49, and Tyr94 ( Figure 2G ). The hypochromic effect of P-selectin on UV absorbance could have been the influence of the binding of PSI-697 or THCMA.…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models

Feng¹,

Wang²,

Muhtar³

et al. 2021

IJN

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Purpose: To assess whether the newly designed small-molecule oral P-selectin inhibitor 3S-1,2,3,4-tetrahydro-β-carboline-3-methyl aspartyl ester (THCMA) as a nanomedicine enhances antithrombosis, anti-inflammation, and antitumor activity more than the clinical trial drug PSI-697. Methods: THCMA was designed as an amphiphile containing pharmacophores of PSI-697. Its nanofeatures were explored with TEM, SEM, Tyndall effect, ζ-potential, FT-ICR-MS, and NOESY 2D 1 H NMR. The P-selectin inhibitory effect of THCMA was demonstrated with molecular docking, ultraviolet (UV) spectra, and competitive ELISA. In vivo and in vitro assays -anti-arterial thrombosis, anti-venous thrombosis, anti-inflammation, antitumor growth, anti-platelet aggregation, rat-tail bleeding time, anticoagulation index, soluble P-selectin (sP-selectin) expression, and serum TNFα expression -were performed to explore bioactivity and potential mechanisms. Water solubility of THCMA was measured using UV-absorption spectra. Results: THCMA self-assembled into nanorings of approximately 100 nm in diameter. Its water solubility was about 1,030-fold that of PSI-697. THCMA exhibited more potent P-selectin inhibitory effect than PSI-697. The oral efficacy of THCMA was 100-fold that of PSI-697 in inhibiting arterial and venous thrombosis and tenfold in inhibiting inflammation. THCMA inhibited thrombosis at a dose that produces no coagulation disorders and no bleeding risk. THCMA exhibited enhanced antitumor activity over PSI-697 without systemic chemotherapy toxicity. THCMA significantly inhibited platelet aggregation in vitro and downregulated the expression levels of serum sP-selectin and TNFα in vivo. Conclusion:A new small-molecule P-selectin inhibitor, THCMA, has been successfully designed as a nanomedicine with largely enhanced oral efficacy compared to the clinical trial drug PSI-697, and thus might be developed for the oral treatment of arterial thrombosis, venous thrombosis, inflammation, and cancer-associated thrombosis.

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Section: Resultsmentioning

confidence: 99%

Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models

Feng¹,

Wang²,

Muhtar³

et al. 2021

IJN

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“…3 ), although an addition of polynomial terms is required to improve prediction performances. Ozone is generally consumed by organic contaminants in water ( Park et al., 2001 ), and the established models lack variables related to disinfectant-consuming substances ( e.g., DOC and SS) ( Sohn et al., 2004 ; Du et al., 2020 ), so the polynomial terms might compensate for the missing but essential variables. However, in this study, only the small number of variables was available and thus an addition of polynomial terms does not always support the prediction, which might attribute to the lack of fit to some datasets.…”

Section: Discussionmentioning

confidence: 99%

Predictive water virology using regularized regression analyses for projecting virus inactivation efficiency in ozone disinfection

et al. 2021

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Wastewater reclamation and reuse have been practically applied to water-stressed regions, but waterborne pathogens remaining in insufficiently treated wastewater are of concern. Sanitation Safety Planning adopts the hazard analysis and critical control point (HACCP) approach to manage human health risks upon exposure to reclaimed wastewater. HACCP requires a predetermined reference value (critical limit: CL) at critical control points (CCPs), in which specific parameters are monitored and recorded in real time. A disinfection reactor of a wastewater treatment plant (WWTP) is regarded as a CCP, and one of the CCP parameters is the disinfection intensity ( e.g. , initial disinfectant concentration and contact time), which is proportional to the log reduction value (LRV) of waterborne pathogens. However, the achievable LRVs are not always stable because the disinfection intensity is affected by water quality parameters, which vary among WWTPs. In this study, we established models for projecting virus LRVs using ozone, in which water quality and operational parameters were used as explanatory variables. For the model construction, we used five machine learning algorithms and found that automatic relevance determination with interaction terms resulted in better prediction performances for norovirus and rotavirus LRVs. Poliovirus and coxsackievirus LRVs were predicted well by a Bayesian ridge with interaction terms and lasso with quadratic terms, respectively. The established models were relatively robust to predict LRV using new datasets that were out of the range of the training data used here, but it is important to collect LRV datasets further to make the models more predictable and flexible for newly obtained datasets. The modeling framework proposed here can help WWTP operators and risk assessors determine the appropriate CL to protect human health in wastewater reclamation and reuse.

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“…On the other hand, biological methods have received a signi cant awareness of the scienti c community during the last decades, because of their many advantages, in terms of pro tability, environmental benignity and simple operation (Sponza et al 2005). These biological processes are based, on the processes of bioremediation, in which the main example of the most used wastewater treatment in the world is the activated sludge process (Du et al 2020;Zeghioud et al 2021). Microorganisms are used for subsequent treatment in an aerated bioreactor.…”

Section: Introductionmentioning

confidence: 99%

Activated Sludge-Assisted Phytoremediation For Dye Removal

Hocini

Benabbas

Khellaf

et al. 2021

Preprint

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We report the biodegradation of dye pollutants by a green process that combines the microbial activity of activated sludge with phytoremediation ability of the aquatic plant L. gibba. The obtained results showed that the combination of the two processes when the pollutant was present at concentration of 50 mg/L, lead to a dye removal of 95 and 70% for VB-20 and DR-89, respectively. The biodegradability index based on COD and BOD5 measurement was equal to 3.1 for DR-89 and 2.0 for VB-20, confirming that DR-89 was removed by biosorption phenomena and only VB-20 was transformed into biodegradable compounds. UV-visible, FT-IR and LC/MS analysis were used as a tool for the monitoring of the biodegradation metabolite and the results showed that VB-20 biodegradation occurred by the cleavage of anthraquinone cycle and transformation of aromatic compounds to light hydrocarbon chain; this was further confirmed by the calculation of Fukui index using DFT method. This study highlighted the synergy between the phytoremediation and biodegradation process for organic dye removal.

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Effect of ozone pretreatment on characteristics of dissolved organic matter formed in aerobic and anaerobic digestion of waste-activated sludge

Cited by 15 publications

References 36 publications

Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models

Nanoparticles of a New Small-Molecule P-Selectin Inhibitor Attenuate Thrombosis, Inflammation, and Tumor Growth in Two Animal Models

Predictive water virology using regularized regression analyses for projecting virus inactivation efficiency in ozone disinfection

Activated Sludge-Assisted Phytoremediation For Dye Removal

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