2023
DOI: 10.1016/j.jormas.2022.09.013
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Effect of ozone therapy on the modulation of inflammation and on new bone formation in critical defects of rat calvaria filled with autogenous graft

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Cited by 6 publications
(4 citation statements)
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“…The application of gaseous ozone was reported to improve bone metabolism and homeostasis in a zoledronate-treated rat model of osteoporosis, which showed a synergistic effect between zoledronate and ozone associated with increased bone regeneration ( 87 ). This ozone-induced biostimulatory effect was further confirmed by other previous studies that reported increased bone regeneration of calvarial defects of both healthy rats and rats with diabetes mellitus ( 88 , 89 ). Diabetes mellitus and hyperglycemia are associated with impaired healing processes due to activation of the NF-κB pathway, as well as increased alkaline phosphatase expression and suppressed osteocalcin, MMP-13, VEGF and glycolytic enzyme levels in osteoblasts, resulting in osteoporosis ( 90 , 91 ).…”
Section: Biostimulation Of Dental and Periodontal Structuressupporting
confidence: 87%
“…The application of gaseous ozone was reported to improve bone metabolism and homeostasis in a zoledronate-treated rat model of osteoporosis, which showed a synergistic effect between zoledronate and ozone associated with increased bone regeneration ( 87 ). This ozone-induced biostimulatory effect was further confirmed by other previous studies that reported increased bone regeneration of calvarial defects of both healthy rats and rats with diabetes mellitus ( 88 , 89 ). Diabetes mellitus and hyperglycemia are associated with impaired healing processes due to activation of the NF-κB pathway, as well as increased alkaline phosphatase expression and suppressed osteocalcin, MMP-13, VEGF and glycolytic enzyme levels in osteoblasts, resulting in osteoporosis ( 90 , 91 ).…”
Section: Biostimulation Of Dental and Periodontal Structuressupporting
confidence: 87%
“…33 In vitro and in vivo studies found that the use of oxygen-releasing techniques can decrease apoptosis and necrosis by providing sufficient oxygen for a prolonged period, potentially increasing vascularization and angiogenesis events. 11,31 The use of ozone when evaluated for the treatment of wounds in diabetic foot found that the treatment can improve the levels of transforming growth factors-β (TGF-β)-which is present in the processes of bone neoformation, stimulating the production of collagen (important constituent of bone) and platelet-derived growth factor (PDGF), which are known to accelerate tissue regeneration. 36 As disadvantages of using therapeutic ozone, the risks of severe oxidation, generation of free radicals and lipid peroxidation must be considered.…”
Section: The Role Of Oxygen To Enhance Bone Formation and Regenerationmentioning
confidence: 99%
“…antimicrobial, anti-inflammatory, healing, immunostimulant, antihypoxic, analgesic, detoxifying, bioenergetic and biosynthetic situations. 10,11 As mentioned so far, ozone therapy has emerged as a field of vast knowledge for the activation of regenerative processes. Its use as a tool to increase the biological potential of regenerative 3D biomanufatured scaffolds for the treatment of critical size defects should be considered.…”
mentioning
confidence: 99%
“…Ozone is now another suitable option for intra-articular injection in treating stifle osteoarthritis [9]. Ozone has been shown to reduce pain and inflammation associated with stifle osteoarthritis [10,11,12]. Upon interacting with bodily fluids, by inducing the release of various factors from endothelial cells and restoring an equilibrium of the cells redox balance, O₃ serves as a bioregulation component [13].…”
Section: Introductionmentioning
confidence: 99%