Effect of Panax ginseng extract (G115) on angiotensin-converting enzyme (ACE) activity and nitric oxide (NO) production

Inhibitory effect of phenolic compounds from grape seeds (Vitis vinifera L.) on the activity of angiotensin I converting enzyme

“…An analogous behavior on the activity of ACE was referred by Persson, Dong, and Persson (2005), who studied the combination of low non-effective concentrations of ginseng (0.1 mg/mL) with enalaprilat (10 À11 mol/L), another ACE inhibitor. Results showed a significant reduction of ACE activity in human cultured endothelial cells from umbilical cords (HUVEC) in relation to that measured with enalaprilat alone, specifically from 5.5 to nearly 2 mmol/(L min).…”

Korean red ginseng inhibits arginase and contributes to endothelium-dependent vasorelaxation through endothelial nitric oxide synthase coupling

“…Ginseng extract exerts a direct vasodilatory effect by releasing NO in an endothelium-dependent manner [35]. Furthermore, the beneficial effects of ginseng on vascular system may be dependent on the activation of Akt/PI3K signal transduction [8], inhibition of angiotensin converting enzyme [36], and inhibition of calcium ion influx resulting from the blockade of the calcium ion channel [37]. Here, we demonstrate that arginase is a novel target protein for KG-WE.…”

Angiotensin I-converting enzyme (ACE) inhibition and nitric oxide (NO)-mediated antihypertensive effect of octaphlorethol A isolated from Ishige sinicola: In vitro molecular mechanism and in vivo SHR model

“…It is known that the production of angiotensin II from angiotensin I and the degradation of bradykinin play a key role in the development of hypertension (Lee et al, 2014). Many natural products have been investigated for their ability to inhibit the activation of ACE and enhance NO generation (Park et al, 2012;Persson, Dong, & Persson, 2006). In the present study, we examined the effect of OPA, a phlorotannin compound isolated from I. sinicola, on ACE inhibition and NO production, as well as its underlying mechanism of action.…”

“…Therefore, interest in alternative therapies and therapeutic natural products, particularly those derived from herbs, for hypertension is growing (Kim et al, 2011;Lorenz et al, 2004;Persson et al, 2006). After oral administration of the OPA, the SBP of SHR decreased by 21.9 mmHg in 6 h, indicating that the compound has an intense effect on the reduction of blood pressure in mammals.…”