Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats

Tian, Zhihao; Pang, Huanhuan; Du, Shouying; Lu, Yang; Zhang, Lin; Wu, Huichao; Guo, Shuang; Wang, Min; Zhang, Qiang

doi:10.1016/j.jchromb.2016.12.007

Cited by 41 publications

(30 citation statements)

References 37 publications

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“…Aspirin is rapidly decomposed into salicylic acid in the blood and gastrointestinal tract after drug administration. At present, the pharmacokinetic study of aspirin is often quantified by salicylic acid [10]. Subsequently, we demonstrated that the hypoxic environment of the plateau increases the bioavailability of aspirin by attenuating the metabolic activity of the gut flora (Fig 4), which is consistent with the metabolic effects of fecal suspensions on aspirin.…”

Section: Plos Onesupporting

confidence: 77%

Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Sun¹,

Zhang²,

Zhao³

et al. 2020

PLoS ONE

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Since hypobaric hypoxia significantly affects metabolic characteristics of intestinal flora, which plays an important role in the biotransformation of aspirin, high altitudes may influence the pharmacokinetics and therapeutic effects of aspirin in the intestines. In the present study, to test alterations of intestinal microbiota at high altitude comparing to that at low altitude, we analyzed rat feces from plain group and high-altitude group by 16S rRNA analysis. To detect concentrations of aspirin and salicylic acid, we established a reliable liquid chromatography tandem mass spectrometry method to measure aspirin and salicylic acid concentrations in fecal suspensions and plasma. Our study found that the plateau hypoxic environment caused a significant increase in Bacteroides in rat feces, while Corynebacterium, Prevotella, and Coprococcus were declined. In addition, compared with the plain group, the metabolic activity of fecal suspensions from the plateau group on aspirin was significantly reduced. More importantly, these changes in the intestinal microbiota led to increasing absorption of aspirin in the rats after rapidly ascent to the plateau, and a reduction in the pharmacodynamic index TXB2, which would possibly result in bleeding. In conclusion, our research provides new ideas for changes in plateau pharmacokinetics, and then guide the corresponding reduction in aspirin dose for the population quickly entering the plateau.

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Section: Plos Onesupporting

confidence: 77%

Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Sun¹,

Zhang²,

Zhao³

et al. 2020

PLoS ONE

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“…The results showed that the values of AUC and Cmax of salicylic acid were greater in the three co-administration groups of rosella water extract and aspirin than in the single aspirin group. Previous studies investigating the interaction between aspirin and Panax notoginseng showed an increase in AUC of salicylic acid when given in combination, but this increase was not statistically significant 16 . Based on the value of elimination half-life (t ½) salicylic acid in the co-administration group has increased compared to the single aspirin group, this means that the presence of an aqueous extract of Hibiscus sabdariffa L results in slower elimination of salicylic acid, but this increase is not statistically significant.…”

Section: Discussionmentioning

confidence: 63%

Pharmacokinetics of Salicylic Acid in an Interaction Study of Aqueous Extract of Hibiscus Sabdariffa L With Aspirin in Rat Plasma

Zahriah¹,

Saputri²,

Harahap³

2019

Int Res J Pharm

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This study intends to find out whether co-administration of aqueous extract of Hibiscus sabdariffa L and aspirin would affect the pharmacokinetics profile of aspirin's metabolite, namely salicylic acid. Four groups of Sprague Dawley rats (n=6/group) received aspirin alone (10 mg/kg orally), aqueous extract of Hibiscus sabdariffa L 62.5 mg/kg with Aspirin 10 mg/kg, orally, aqueous extract of Hibiscus sabdariffa L 125 mg/kg with Aspirin 10 mg/kg, orally, and aqueous extract of Hibiscus sabdariffa L 250 mg/kg with Aspirin 10 mg/kg, orally. Aqueous extract of Hibiscus sabdariffa L was given once daily for seven days. On the 7th day, 30 minutes after administration of aqueous extract of Hibiscus sabdariffa L followed by administration of aspirin, then the plasma sample was taken at a different point. HPLC-UV method was used to identify the pharmacokinetics profile of salicylic acid contained in rat plasma. Co-administration of aqueous extract of Hibiscus sabdariffa L and aspirin showed an increase in AUC, Cmax, and t1/2 of salicylic acid, but the increase was not significant (p>0.05). In conclusion, aqueous extract of Hibiscus sabdariffa L does not affect the pharmacokinetics profile of salicylic acid

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“…These have been used for more than a thousand years with generally carry a low risk of negative side effects. Panax notoginseng, as traditional Chinese medicine has a long history of high clinical value, such as anti-inflammatory [16,20,31,32], antioxidation, inhibition of platelet aggregation, regulation of blood glucose [27,33,34] and blood pressure [35][36][37], inhibition of neuronal apoptosis [14,38,39] and neuronal protection. Currently, Panax notoginseng may improve mental function, have anti-insomnia and anti-depression effects, alleviate anxiety, and decrease neural network excitation [25,26].…”

Section: Discussionmentioning

confidence: 99%

“…And there are others reported to be flavonoids, cyclopeptides, saccharides and inorganic elements [30]. Pharmacological studies have shown that notoginseng and its extracts have many functions, such as anti-inflammatory [16,20,31,32], anti-oxidation, inhibition of platelet aggregation, regulation of blood glucose [27,33,34], blood pressure [35][36][37], inhibition of neuronal apoptosis [14,38,39] and neuronal protection [30].…”

Section: Introductionmentioning

confidence: 99%

“…Experiments also have shown that PNS modulates Na + currents and Ca 2+ concentrations, increases nestin and brain-derived neurotrophic factor (BDNF) [14,19,29,[43][44][45][46][47]. Moreover, PNS or single compounds exerted antidepressant-like effects by regulating the release of interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α or anti-inflammatory cytokines IL-4 and IL-10 [10,20,29,31,32,36,[48][49][50][51][52][53][54][55][56]. Such breakthroughs have been made, there is antidepressant effects on estrogen in the human body.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

Xie¹,

Meng²,

Zhai³

et al. 2018

Preprint

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Panax notoginseng, as traditional Chinese medicine, has a long history of high clinical value, such as anti-inflammatory, anti-oxidation, inhibition of platelet aggregation, regulation of blood glucose and blood pressure, inhibition of neuronal apoptosis and neuronal protection, and its main ingredients are Panax notoginseng saponins (PNS). Currently, Panax notoginseng may improve mental function, have anti-insomnia and anti-depression effects, alleviate anxiety, and decrease neural network excitation. However, the underlying effects and the mechanisms of Panax notoginseng and its containing chemical constituents (PNS) on these depression-related or anxiety-related diseases has not been completely established. This review summarized the antidepressant or anxiolytic effects and mechanisms of PNS, and analyzed network targets of antidepressant or anxiolytic actions with network pharmacology tools to provide directions and references for further pharmacological studies and new ideas for clinical treatment of nervous system diseases and drug studies and development.

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Effect of Panax notoginseng saponins on the pharmacokinetics of aspirin in rats

Cited by 41 publications

References 37 publications

Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Effects of intestinal flora on the pharmacokinetics and pharmacodynamics of aspirin in high-altitude hypoxia

Pharmacokinetics of Salicylic Acid in an Interaction Study of Aqueous Extract of Hibiscus Sabdariffa L With Aspirin in Rat Plasma

Panax Notoginseng Saponins: A Review of Its Mechanisms of Antidepressant or Anxiolytic Effects and Network Analysis on Phytochemistry and Pharmacology

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