Effect of panthetine on postheparin lipolytic activity ad lipid peroxidation in the myocardium

Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals ‐ The role of glutathione

“…These results obtained with cells in vitro as well as literature reports on the beneficial effects of pantothenic acid and its derivatives in various pathologies [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] prompted us to investigate whether these compound may protect whole animals against low doses of γ-radiation. One of the mechanisms of the damaging effects of ionising radiation is the generation of ROS [27,28].…”

Protective effect of vitamin B5 (dexpanthenol) on cardiovascular damage induced by streptozocin in rats

“…Serum MDA level decreased by 500 mg/kg DEX, hence testicular tissue injury alleviated in ischemia-perfusion model (14). Pantethine MDA reducing effect has been found in 57.4 % in myocardium (15). Furthermore, ATP synthesis increased in cardiac (16) and lymphoblastoic cells by PA treatment (17).…”

“…Although many earlier researches revealed that panthothenic acid (PA) and its precursor dexpanthenol (DEX) had a benefi cial effect in several clinical or experimental conditions including Pantothenate kinase-associated neurodegeneration (PKAN) (10), liver failure (11), radiation damage (12), ischemia-reperfusion injury of brain (13) and testicular tissue (14), the experimental data focusing on cardio protective effect are still very limited. It has been reported that PA and derivatives should be considered as cardiac protectors throughout increasing ATP content, reducing lactate and malondialdehyde (MDA) level in isolated ischemiareperfusion heart model (15,16). Furthermore, the other studies indicate diverse functions of PA such as regulation of coenzyme A (CoA) (17,18), glutathione synthesis (12,17) and cholesterol synthesis of cell membranes (19).…”