Effect of Papaverine on the Flow of Left Internal Thoracic (Mammary) Artery for Coronary Artery Bypass Grafting

Siddiqeh, Musfireh

doi:10.26717/bjstr.2018.04.0001022

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…ITA use is especially of value in diabetic patients due to reduced incidence of postoperative cardiac events. [1][2][3][4][11][12][13][14][15][16][17] ITA is a branch of subclavian artery. ITA has more nutrient supply to its wall, quick removal of metabolites, production of prostacyclin and nitric acid from its wall all play a role in reducing the incidence of adverse cardiac effects.…”

Section: Discussionmentioning

confidence: 99%

Frequency of deep infection of the sternal wound in diabetic patients utilizing skeletonized versus pedicled harvesting technique of internal thoracic artery after CABG surgery.

Tanveer

Khan

Musharaf

et al. 2019

TPMJ

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Objectives: After coronary artery bypass graft (CABG) surgery, infection of the sternum is a serious issue as it would adversely affect the mortality of patient. Left internal thoracic artery (LITA) has significant benefits but after its utilization occurrence of sternal infection is documented especially in diabetic patients due to impairment in blood flow of sternum. Our objective was to document the frequency of deep infection of the sternal wound in patients with diabetes utilizing skeletonized versus pedicled harvesting technique of the left ITA after CABG Surgery in our population. Study Design: An observational study was retrospectively done. Setting: National Institute of Cardiovascular Diseases, Karachi. Period: January 2013 to October 2015. Material and Methods: The sample size of the study was determined to be a total of two hundred and twenty patients who had primary, isolated and elective CABG surgery. One hundred and ten patients were included in whom skeletonized left ITA was utilized and in one hundred and ten patients pedicled left ITA was utilized. We used the statistical Chi square test and p < 0.05 was considered significant. Results: Deep infection of the sternal wound occurred in 3.64% of the patients with diabetes in whom the pedicled left ITA was utilized and did not occur in any of the diabetic patients in whom the skeletonized left ITA was utilized. Post CABG surgery frequency of deep infection of the sternal wound was greater in those patients in whom the LITA was harvested utilizing the pedicled technique (p<0.05). Conclusion: There is decreased frequency of deep infection of the sternal wound in patients with diabetes utilizing the skeletonized harvesting technique of the left ITA after CABG Surgery.

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Section: Discussionmentioning

confidence: 99%

Frequency of deep infection of the sternal wound in diabetic patients utilizing skeletonized versus pedicled harvesting technique of internal thoracic artery after CABG surgery.

Tanveer

Khan

Musharaf

et al. 2019

TPMJ

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“…Dregelid et al 13 revealed that an intraluminal injection of a papaverine solution and external papaverine exposure provide a greater blood flow rate and distal dilation but at a significant risk of mechanical wall injury. Siddiqeh 14 demonstrated that papaverine was a safe and effective vasodilator for raising the mean blood flow of the LIMA/left internal thoracic artery (LITA) for CABG. Koramaz et al 15 demonstrated that papaverine increased the flow rates of the grafts 30 minutes after papaverine injection.…”

Section: Effect Of Papaverine On Blood Flow and Spasm Of The Imamentioning

confidence: 99%

Use of papaverine in harvesting internal mammary graft in coronary artery bypass grafting: An update

Jannati

2022

Surgical Practice

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The left internal mammary artery (LIMA) graft is the main arterial graft that is used in coronary artery bypass grafting (CABG). The spasm of LIMA is a complication that frequently occurs while harvesting the LIMA and may lead to morbidity and mortality in patients after CABG. Clinically, papaverine is the most frequently used vasodilator. In this review, we evaluated the administration of papaverine in IMA grafts during CABG. It was shown that administration of papaverine into the LIMA improves the blood flow and abolishes vasospasm of the LIMA. Moreover, the intraluminal and perivascular administrations of papaverine are more effective than topical administration. Higher concentrations of papaverine should be used with caution because it may lead to endothelial damage.

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Effect of Papaverine on the Flow of Left Internal Thoracic (Mammary) Artery for Coronary Artery Bypass Grafting

Cited by 2 publications

References 12 publications

Frequency of deep infection of the sternal wound in diabetic patients utilizing skeletonized versus pedicled harvesting technique of internal thoracic artery after CABG surgery.

Frequency of deep infection of the sternal wound in diabetic patients utilizing skeletonized versus pedicled harvesting technique of internal thoracic artery after CABG surgery.

Use of papaverine in harvesting internal mammary graft in coronary artery bypass grafting: An update

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