Effect of Papaya Leaves (Carica papaya L.) Extract on Immune Response (TLR-7, TLR-9) and Inflammation (COX-2) in Rats Induces DMBA (7,12-Dimethylbenz[a]antrasen)

Beneficial Role of Carica papaya Extracts and Phytochemicals on Oxidative Stress and Related Diseases: A Mini Review

“…Meanwhile, Aruoma and colleagues demonstrated that fermented papaya preparation (FPP) inhibited H 2 O 2 -induced phosphorylation of Akt and p38, as well as downregulating MAPK pathway [16]. An in vivo study showed that Carica papaya leaf extract at a dose of 1.32 µg/mL demonstrated immune modulation properties [17]. In vitro antioxidant enzyme assay Aqueous extract of papaya unripe peel at 2 mg dry weight/mL increased SOD activity by 21.9%.…”

“…High phenolic and flavonoid content in papaya seed extracts were proposed to act as free radical scavengers and metal ion chelators [15]. Phytochemicals including tocopherols and quercetin are showed to enhance AMP-activated protein kinase (AMPK) activation, as well as the inhibition of COX-2 expression [17]. In addition, a range of phytochemicals with great strength of anti-inflammatory effect, such as benzyl isothiocyanate (BiTC), β-carotene, lycopene, and vitamin C could be found in various parts of papaya fruits, in either pulp or seeds.…”

Therapeutic potential of Carica papaya leaf extract for the treatment of dengue

“…Numerous studies that have been published have found a connection between platelet count and the prognosis of dengue6. Furthermore, papaya leaf extract can boost the immune system and lower inflammation7. According to a meta-analysis, a viable option for raising the platelet count in dengue patients was Carica papaya leaf extract8.…”