Effect of Para-Aminobenzoic Acid on Murine Typhus a Clinical Study of 60 Cases

Diaz-Rivera, R S; Acosta, Catalina

doi:10.1097/00000441-194901000-00002

Cited by 5 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study retrospectively reviewed patients in the British Army Middle East Forces. The other included studies were a prospective study of an outbreak in Panama in 1947 [ 10 ], a trial of drug therapy with para-aminobenzoic acid compared with no treatment in Puerto Rico [ 11 ], a retrospective chart review of patients presenting at a hospital in Israel from 1976 to 1985 [ 12 ], another reviewing patients at four hospitals in southern Texas from 1980 to 1987 [ 13 ], a prospective and retrospective study of patients in a hospital in Spain from 1979 to 1995 [ 14 ], a second study from Spain reviewing patients presenting at a hospital in the Canary islands from 2000 to 2002 [ 15 ], a prospective study of Bedouin children presenting at a hospital in Israel from 2003 to 2005 [ 16 ], a retrospective study of patients diagnosed in a district in New Zealand in 2006 [ 17 ], a retrospective outbreak investigation in Texas conducted by the CDC and Texas authorities in 2008 [ 18 ], a retrospective study of patients diagnosed in Tunisia from 2006 to 2008 [ 19 ] and a retrospective chart review of patients presenting at two hospitals in Texas from 2013 to 2016 [ 20 ]. All included studies were published in English.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of the untreated mortality of murine typhus

Doppler

Newton

2020

PLoS Negl Trop Dis

View full text Add to dashboard Cite

Murine typhus is an acute febrile, flea-borne disease caused by the bacteria Rickettsia typhi. The disease occurs worldwide but is likely underrecognized due to its non-specific symptoms, causing significant morbidity. A systematic review found disease complications in one-fourth of all patients and a long fever duration in those untreated. Although mortality in treated cases is estimated to be very low, some case series have shown a notably higher mortality in untreated patients. This study aimed to describe the outcomes and estimate the mortality of untreated murine typhus through a comprehensive systematic literature review. We systematically searched the literature for articles describing untreated murine typhus patients, excluding cases with no laboratory assay confirmed diagnosis, those who received efficacious treatment, had incomplete information on primary outcome and articles describing less than 10 patients and performed a narrative synthesis of the study findings. The study protocol followed the PRISMA guidelines and was part of a more extensive protocol registered at PROSPERO (CRD42018101991). Twelve studies including a total of 239 untreated patients matched the eligibility criteria. Only a single study reported one death in 28 patients, giving a patient series mortality of 3.6% and an overall mortality of 0.4% in 239 untreated patients. Complications were reported in 10 of the 12 studies and included involvement of the central nervous system, kidney and lung, with a hospitalisation rate of 70% and ICU admission rate of 27% in one study. The mean duration of fever in untreated patients was 15 days in two and 12.7 days in one study. Although the untreated mortality in this study was low, the sample size was small. Murine typhus caused significant morbidity when untreated, leading to high hospitalisation rates and highlighting the importance of early diagnosis and treatment of this neglected disease to reduce disease burden and health-care related costs.

show abstract