Effect of paracetamol and coxib with or without dexamethasone after laparoscopic cholecystectomy

Tiippana, Elina; Bachmann, M.; Kalso, Eija; Péré, P.

doi:10.1111/j.1399-6576.2008.01650.x

Cited by 42 publications

(26 citation statements)

References 44 publications

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“…The efficacy of intravenous paracetamol was similar to other analgesics comprising coxibs and codeine tablets. This similar efficacy corroborates findings of two previous clinical studies with a randomized design (5,11). It should however be underscored that in the present study setting of patients with limited past experience of analgesics, parecetamol had similar efficacy to the other agents.…”

Section: Discussionsupporting

confidence: 80%

Intravenous Paracetamol as an Antipyretic and Analgesic Medication: the Significance of Drug Metabolism

Giamarellos‐Bourboulis

Spyridaki

Savva

et al. 2014

J Pharmacol Sci

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Abstract.One prospective, open-label, non-randomized study was conducted in 100 patients to define the antipyretic and analgesic effect of a new intravenous formulation of 1 g of paracetamol; 71 received paracetamol for the management of fever and 29 received paracetamol for pain relief after abdominal surgery or for neoplastic pain. Serial follow-up measurements of core temperature and of pain intensity were done for 6 h. Additional rescue medications were recorded for 5 days. Blood was sampled for the measurement of free paracetamol (APAP) and of glucuronide-APAP and N-sulfate-APAP by an HPLC assay. Defervescence, defined as core temperature below or equal to 37.1°C, was achieved in 52 patients (73.2%) within a median time of 3 h. Patients failing to become afebrile with the first dose of paracetamol became afebrile when administered other agents as rescue medications. Analgesia was achieved in 25 patients (86.4%) within a median time of 2 h. Serum levels of glucuronide-APAP were greater among non-responders to paracetamol. The presented results suggest that the intravenous formulation of paracetamol is clinically effective depending on drug metabolism.

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Section: Discussionsupporting

confidence: 80%

Intravenous Paracetamol as an Antipyretic and Analgesic Medication: the Significance of Drug Metabolism

Giamarellos‐Bourboulis

Spyridaki

Savva

et al. 2014

J Pharmacol Sci

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“…14 Effect of paracetamol and coxib with or without dexamethasone after laparoscopic cholecystectomy was evaluated and it has been suggested that paracetamol was as effective as parecoxib/valdecoxib for pain after laparoscopic cholecystectomy. 17 In our study, the verbal and visual pain evaluation scores of the paracetamol group are significantly lower than control group. Time of extubation, eye opening, orientation and mobility, and frequency of postoperative nausea, and vomiting are evaluated as parameters of recovery characteristics.…”

Section: Discussionmentioning

confidence: 74%

Evaluation of Intravenous Paracetamol Administration on Postoperative Pain and Recovery Characteristics in Patients Undergoing Laparoscopic Cholecystectomy

Salihoğlu¹,

Yıldırım²,

Demiroluk³

et al. 2009

Surgical Laparoscopy, Endoscopy &Amp; Percutaneous Techniques

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Purpose: In this study, the effects of intravenous paracetamol treatment on early postoperative period analgesia and recovery characteristics after laparoscopic cholecystectomy have been evaluated.Methods: Forty patients whose American Society of Anesthesiologists physical status I or II underwent laparoscopic cholecystectomy and randomly divided into 2 equal groups. In the first group, 1 g paracetamol was given to the patients intravenously after intubation before start of the surgery in 15 minutes. The 100 mL 0.9% NaCl was infused intravenously for the control group in 15 minutes. Postoperative pain was evaluated and recovery characteristics were evaluated.Results: Verbal and visual pain scores of the paracetamol group were significantly lower than control group (P<0.05). First morphine requirement and total administered morphine dose and duration of staying in recovery room were significantly decreased in the paracetamol group (P<0.05).Conclusions: Beside its effective analgesic properties, paracetamol administration during per operative period supports effective and faster recovery.

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“…One hundred sixty patients who underwent elective laparoscopic cholecystectomy were randomized by Tiippana and colleagues to four groups of 40 patients [123]. Groups 1 and 3 received parecoxib 40 mg i.v.…”

Section: Comparative Studiesmentioning

confidence: 99%

Perioperative Intravenous Acetaminophen and NSAIDs

Smith

2011

Pain Med

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Effect of paracetamol and coxib with or without dexamethasone after laparoscopic cholecystectomy

Abstract: Paracetamol was as effective as parecoxib/valdecoxib for pain after LCC. Dexamethasone decreased the need of oxycodone in phase 2 PACU. The effect of dexamethasone was similar in paracetamol and parecoxib/valdecoxib patients.

Cited by 42 publications

References 44 publications

Intravenous Paracetamol as an Antipyretic and Analgesic Medication: the Significance of Drug Metabolism

Intravenous Paracetamol as an Antipyretic and Analgesic Medication: the Significance of Drug Metabolism

Evaluation of Intravenous Paracetamol Administration on Postoperative Pain and Recovery Characteristics in Patients Undergoing Laparoscopic Cholecystectomy

Perioperative Intravenous Acetaminophen and NSAIDs

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