Effect of parathyroid hormone and uremic sera on the autoagglutination and sedimentation of human red blood cells

Earon, Yehoshua; Blum, Miriam; Bogin, E.

doi:10.1016/0009-8981(83)90284-x

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Bogin et al (4)(5)(6)(7)(8) have shown that high levels of the hormone are toxic to biological Systems. Because of the common use of Ca 2+ blockers äs therapeutic agents in the management of cardiac arrhythmias and coronary diseases, attention should be paid to blood levels of parathyroid hormone, especially in patients with renal failure.…”

Section: Discussionmentioning

confidence: 99%

“…High parathyroid hormone levels, which are commonly seen in uraemic patients (3), were shown to be toxic to many biological Systems (4)(5)(6)(7)(8) and were postulated to be one of the toxic factors responsible for some of the observed clinical Symptoms of uraemia. Calcium antagonists are a diverse class of organic compounds used äs theräpeutic agents in the management of cardiac arrhythmias and coronary disease.…”

Section: Introductionmentioning

confidence: 99%

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Short Communication/Kurzmitteilung

1987

Clinical Chemistry and Laboratory Medicine

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The effects of the Ca antagonist, verapamil, on the behaviour of parathyroid hormone was studied in normal and uraemic male Wistar räts.Parathyroidectomy was by cautery. Acute uraemia was induced by bilateral nephrectomy, and mqderate uraemia by s. c. injection of gentamicin (200 mg/kg). Ethylendiamine tetracetic acid (50 mg/kg · d) was injected subcutaneously.Parathyroid hormone was determined by radioimmunoassay. The degree of üraemiä was determined from plasma urea levels.Renal failure resulted in a significant increase in plasma parathyroid honnone (x ± SEM, ng/1) (84 ±6, n = 10, in the control; 277 ± 39, n = 7, in the moderate uraemies and 667 ± 128, n = 6, in the acute uraemies).Injection of verapamil significantly increased plasma levels of parathyrpid hormone, ranging from 21% in the controls to 62% in the moderate uraemia group.In the acute uraemies, parathyröid hormone levels were very high and verapamil did not eause any further elevation of the hormone in the blood.Parathyroidectomy significantly lowered plasma paräthyroid hormone, and verapamil resulted in a mean increase of 29%.EDTA caused an increase of 64%, eompared with the control group.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Short Communication/Kurzmitteilung

1987

Clinical Chemistry and Laboratory Medicine

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“…Levels of parathyroid hormone used in this study are comparable to levels seen in the blood of chronic renal failure patients on dialysis. Furthermore, the observed effects of parathyroid hormone on the agglutination of red blood cells were mimicked by ultrafiltrates obtained from sera of uraemic patients (11). It is reasonable to postulate that since the pregnancy period of rabbits is significantly shorter than the lifetime of circulating erythrocytes, the blood of newborn rabbits contains a relatively larger Proportion of young cells in comparison to adult rabbits.…”

mentioning

confidence: 97%

Effect of Parathyroid Hormone on the Fragility and Enzyme Activities of Red Blood Cells from Young and Mature Rabbits

Bogin¹,

Malachi²,

Djaldeti³

et al. 1987

Clinical Chemistry and Laboratory Medicine

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Summary:The effect of parathyroid hormone on erythrocytes from newborn and adult rabbits was studied in relation to the fragility pattern in hypotonic salt Solutions and the activities of Ca-and Mg-dependent ATPases. Mediän osmotic fragility of red blood cells from newborn rabbits was significantly higher than in red blood cells from mature rabbits. Parathyroid hormone increased the mean osmotic fragility of red blood cells from newborn and adult rabbits, but showed the greater effect on those from newborns.

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The relationship of calcium and parathyroid hormone in their effect on heart cells

Bogin

Harary

1987

Mol Cell Biochem

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Parathyroid hormone (PTH), the plasma concentration of which is raised in uremia, has been suggested as one of the agents responsible for the myocardial changes commonly seen in uremia. The effect of intact PTH on rat heart cells grown in tissue culture has been studied. Addition of the hormone to the media significantly stimulated beating rate. The stimulation was directly proportional to the amount of PTH in the medium. Excessively high concentration of PTH caused immediate cessation of the beating, which was reversed by the addition of calcium to the medium. The extent of stimulation by PTH was inversely proportional to the calcium concentrations in the medium. Isoproterenol and phenylephrine at excessively high concentrations in the medium did not mimic the PTH effect either alone or together with PTH. When beating ceased due to verapamil the effect was not reversed by the addition of calcium to the medium. Calcium added to the myocytes seen after beating ceased reversed the effect and the cells started to beat again. Cells kept for a longer period in the arrested state were not revived by the addition of calcium.

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Effect of parathyroid hormone and uremic sera on the autoagglutination and sedimentation of human red blood cells

Cited by 6 publications

References 20 publications

Short Communication/Kurzmitteilung

Short Communication/Kurzmitteilung

Effect of Parathyroid Hormone on the Fragility and Enzyme Activities of Red Blood Cells from Young and Mature Rabbits

The relationship of calcium and parathyroid hormone in their effect on heart cells

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