Effect of parathyroidectomy on bone tissue biomarkers and body composition in patients with chronic kidney disease and secondary hyperparathyroidism

Siqueira, Flávia; Oliveira, Karin Carneiro de; Dominguez, Wagner Vasques; Truyts, César Augusto Madid; Moysés, Rosa Maria Affonso; Reis, Luciene M. dos; Jorgetti, Vanda

doi:10.1038/s41430-020-00829-7

Cited by 8 publications

(3 citation statements)

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“…These findings supported the idea of hyperparathyroidism causing PEW and removal of excess PTH could improve nutritional status. Other small uncontrolled observational studies have reported similar observation (8)(9)(10)(11)30). Although the findings on the changes in the BMI were not consistent in the primary analysis, further analyses on the degree of the changes revealed a more frequent and a more substantial increase in the BMI in the PTX group compared with the two control groups.…”

Section: Discussionsupporting

confidence: 63%

“…The recent investigation by our group also revealed worsening nutritional impairment among maintenance HD patients with severe hyperparathyroidism despite stable dietary protein intake (7). Other small studies have reported an increase in body weight, muscle strength and serum albumin after parathyroidectomy (8)(9)(10)(11). These findings suggested adverse impacts of hyperparathyroidism on nutritional status and parathyroidectomy might convey favorable nutritional outcome.…”

Section: Introductionmentioning

confidence: 52%

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Improvement of nutritional status after parathyroidectomy in patients receiving maintenance hemodialysis

et al. 2023

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Aims/IntroductionParathyroidectomy is associated with improved survival in patients with end-stage kidney disease. Protein-energy wasting (PEW) is common in patients with kidney failure and predicts poor outcomes. Recent clinical trials have linked hyperparathyroidism to PEW. The present retrospective cohort study examined whether parathyroidectomy was associated with improvement in nutritional status in maintenance hemodialysis patients.Materials and methodsOne hundred twenty-nine maintenance hemodialysis patients who had successful parathyroidectomy during 2012–2018 were identified (PTX group) and matched 1:1 to 479 patients with parathyroid hormone (PTH) levels ≤1,000 pg./mL (non-PTX control group) and 187 patients with PTH levels >1,000 pg./mL (pre-PTX control group) by propensity score. The matchings yielded 120 matched pairs from PTX and non-PTX groups (cohort 1) and 76 matched pairs from PTX and pre-PTX groups (cohort 2). Baseline and follow-up nutritional parameters associated with PEW were compared over the 12-month study period.ResultsIn cohort 1, substantially lower serum albumin and serum creatinine/body surface area (Cr/BSA) and higher proportions of patients with serum albumin ≤38 g/L (low albumin) and serum Cr/BSA ≤380 μmol/L/m2 (low Cr/BSA) were observed in the PTX group. These parameters improved significantly after parathyroidectomy. Total lymphocyte count (TLC) was comparable at baseline but the percentage of patients with TLC <800 cells/mm3 (low TLC) decreased substantially after parathyroidectomy. At follow-up, serum albumin, serum Cr/BSA and proportions of patients with low albumin and Cr/BSA became comparable with the non-PTX control group. The percentage of patients with low TLC became lower in the PTX group. Mixed-models analysis confirmed significant differences in the changes in serum albumin, serum Cr/BSA, and proportions of patients with low albumin and TLC between the two groups. In cohort 2, nutritional parameters were comparable at baseline. At follow-up, serum Cr/BSA was higher and proportions of patients with body mass index ≤18.5 kg/m2, low TLC and low Cr/BSA were lower in the PTX group. Weight gain was more frequent and of greater magnitude in the PTX group in both cohorts. A substantial reduction in blood pressure was also observed in the PTX group.ConclusionSevere hyperparathyroidism was associated with nutritional impairment which improved considerably after parathyroidectomy.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 52%

Improvement of nutritional status after parathyroidectomy in patients receiving maintenance hemodialysis

et al. 2023

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“…The sustained and fast growth of modern industry has led to severe environmental contamination that has had a severe influence on the continuing progress of the whole community; in particular, water pollution has become the primary focus of the array of global environmental problems. , The main contaminants in water resources include various anions and cations, organic solvents and dyes, antibiotics, and microorganic pollutants, which pose latent health risks to living things. − In particular, heavy metal ions are some of the most common water pollutants, because they are highly environmentally poisonous and oncogenic and they bioaccumulate. They easily accumulate in organisms via the food cycle and destroy the regular physical activities of organisms, producing a great threat to the environment and humans.…”

Section: Introductionmentioning

confidence: 99%

Porphyrin-Based Conjugated Microporous Polymers for Highly Efficient Adsorption of Metal Ions

et al. 2022

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The capture and elimination of anions and cations from water have attracted a great deal of attention and are quite vital for clean production and environmental remediation. In this work, we present the synthesis of four porphyrin (Por)-based conjugated microporous polymers (CMPs, namely, Por-CMP-1–4), which were produced through a Sonogashira–Hagihara linked response using porphyrin and acetylene aromatic compounds as building blocks and used as absorbents to eliminate metal ions from water. The as-synthesized Por-CMP-1–4 exhibit an amorphous porous structure and outstanding caloric and physicochemical properties. Taking advantage of their larger specific surface areas, i.e., 541.47, 614.58, 382.38, and 677.90 m2 g–1 for Por-CMP-1–4, respectively, and their chelating active site that originated from the porphyrin ring, Por-CMP-1–4 show better Zn2+, Cu2+, and Pb2+ adsorption ability. Among them, Por-CMP-3 has the greatest adsorbability of 640 mg g–1 for Zn2+, with an adsorption efficiency of 80%, whereas its adsorption capacities for Cu2+ and Pb2+ ions were both 334 mg g–1, with an adsorption efficiency of 42% for Cu2+ and Pb2+. Employing Por-CMP-3 as a representative example, its adsorption kinetics has been systematically investigated. The adsorption behavior of Por-CMP-3 with respect to the Zn2+ ion is shown to exhibit pseudo-first-order kinetics and Langmuir isotherm modes. Meanwhile, the adsorption mechanism is discussed in detail, and it was thought it might be chelation, in which the nitrogen atoms with a single pair of electrons on the porphyrin ring interacted with metal ions to form stable chelation coordination bonds, thus removing metal ions selectively and effectively. Furthermore, Por-CMP-3 exhibited good reusability, retaining 60% of its Zn2+ removal rate after four continuous adsorptions.

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Circulating Osteocalcin Fractions are Associated with Vascular Calcification and Mortality in Chronic Hemodialysis Patients

Lin,

Hsieh,

Huang

et al. 2023

Calcif Tissue Int

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Effect of parathyroidectomy on bone tissue biomarkers and body composition in patients with chronic kidney disease and secondary hyperparathyroidism

Cited by 8 publications

References 44 publications

Improvement of nutritional status after parathyroidectomy in patients receiving maintenance hemodialysis

Improvement of nutritional status after parathyroidectomy in patients receiving maintenance hemodialysis

Porphyrin-Based Conjugated Microporous Polymers for Highly Efficient Adsorption of Metal Ions

Circulating Osteocalcin Fractions are Associated with Vascular Calcification and Mortality in Chronic Hemodialysis Patients

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