Effect of Parenteral Antioxidant Supplementation During the Dry Period on Postpartum Glucose Tolerance in Dairy Cows

Abuelo, Ãngel; Alves-Nores, Victor; Hernández, Joaquín; Muíño, R.; Benedito, José Luís; Castillo, Cristina

doi:10.1111/jvim.13922

Cited by 39 publications

(32 citation statements)

References 41 publications

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“…Selenium (Se) is an essential trace element [ 1 , 2 ] that evinces antioxidant activity [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ], anti-inflammatory [ 2 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ], antimutagenic [ 26 , 27 ], anticarcinogenic [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ] or chemopreventive [ 2 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ], antiviral [ 2 ], antibacterial [ 45 , 46 , 47 , 48 ], antifungal [ 49 , 50 ] and antiparasitic effects [ 51 ,…”

Section: Biochemistry Of Seleniummentioning

confidence: 99%

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Hosnedlová

Kępińska

Skaličková

et al. 2017

IJMS

186

121

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Selenium is an essential trace element important for many physiological processes, especially for the functions of immune and reproductive systems, metabolism of thyroid hormones, as well as antioxidant defense. Selenium deficiency is usually manifested by an increased incidence of retention of placenta, metritis, mastitis, aborts, lowering fertility and increased susceptibility to infections. In calves, lambs and kids, the selenium deficiency demonstrates by WMD (white muscle disease), in foals and donkey foals, it is associated with incidence of WMD and yellow fat disease, and in pigs it causes VESD (vitamin E/selenium deficiency) syndrome. The prevention of these health disorders can be achieved by an adequate selenium supplementation to the diet. The review summarizes the survey of knowledge on selenium, its biological significance in the organism, the impact of its deficiency in mammalian livestock (comparison of ruminants vs. non-ruminants, herbivore vs. omnivore) and possibilities of its peroral administration. The databases employed were as follows: Web of Science, PubMed, MEDLINE and Google Scholar.

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Section: Biochemistry Of Seleniummentioning

confidence: 99%

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Hosnedlová

Kępińska

Skaličková

et al. 2017

IJMS

186

121

View full text Add to dashboard Cite

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“…The SeE [10 mL of SeE, 0.5 mg of Se as sodium selenite, and 56 IU of vitamin E as dl-α-tocopherol acetate per mL, a commercial product; Eurovet Vitamin 50E+SE (Eurovet Animal Health BV, Bladel, the Netherlands), registration number: 12,092,219] was intramuscularly injected first 21 d before the expected calving date, at parturition, and 21 d after calving. The nonsupplemented groups were intramuscularly injected with 10 mL of isotonic saline (Abuelo et al, 2016). All cows were transferred to calving pens bedded with straw near the parturition time.…”

Section: Animals Housing and Feedingmentioning

confidence: 99%

“…Antioxidant supplements can decrease negative effects of BCS loss after calving, and supplementation with Se-vitamin E (SeE) can reduce mastitis, retained placenta, days to estrus, and abortion in dairy cows (Hoedemaker et al, 2009). It was reported that SeE supplementation in the pre-calving period can increase insulin sensitivity, immune responses, and antioxidant capacity after parturition (Abuelo et al, 2016;Mehdi and Dufrasne, 2016). Pilarczyk et al (2012) reported that serum glutathione peroxidase (GSH-Px) had the highest activity in the first stage of lactation in dairy cows, which is reflective of biologically active Se level in the body.…”

Section: Introductionmentioning

confidence: 99%

Effects of close-up body condition score and selenium-vitamin E injection on lactation performance, blood metabolites, and oxidative status in high-producing dairy cows

Zahrazadeh

Ahmad

Farhangfar

et al. 2018

Journal of Dairy Science

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High-producing dairy cows with high pre-calving body condition score (BCS) are more susceptible to metabolic disorders and oxidative stress. The aim of present study was to evaluate the effects of close-up BCS and 3 times Se-vitamin E (SeE) injection on BCS change, blood metabolites, oxidative status, and milk yield in high-producing Holstein cows. A total of 136 multiparous cows were divided into 2 groups based on their BCS including high (HB = 4.00 ± 0.20) and moderate (MB = 3.25 ± 0.25) at 3 wk before expected calving time. Then, each group was divided into 2 subgroups: 3 rounds of SeE injection at 21 d before, and 0 and 21 d after calving (+SeE), and no SeE injection (-SeE). Four final experimental groups were HB+SeE, MB+SeE, HB-SeE, and MB-SeE (34 cows each). Results indicated that interaction effect of BCS and SeE affected serum glucose, and the MB+SeE group had the highest level. The HB cows lost more BCS compared with MB cows during the postcalving period. Moreover, serum insulin concentration increased after SeE injection. The HB cows had higher serum nonesterified fatty acids at 14 d after calving. The MB cows tended to have higher activity of blood glutathione peroxidase over the study period. Furthermore, the SeE-injected cows tended to have higher activity of blood glutathione peroxidase at 28 d after calving. Serum albumin level was increased by SeE injection. The HB cows had greater milk production than MB cows, and SeE-injected cows tended to have higher milk fat percentage and higher fat:protein ratio compared with nonsupplemented cows. It was concluded that SeE injection had beneficial effects on some blood metabolites, albumin as a blood antioxidative parameter, and lactation performance in high-producing dairy cows, especially cows with moderate close-up BCS.

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“…The values derive from calculations denoting glucose half-life time (GHLT), glucose area equivalent (GA), and the rate at which the metabolite is cleared from the blood, among others (Freyer et al, 2004). In cattle, ivGTT is commonly used to test for conditions such as insulin resistance (De Koster and Opsomer, 2013) or determine the levels of insulin sensitivity (Abuelo et al, 2016). The test can also predict changes in nonesterified fatty acids (Boston et al, 2008) and determine the effects of certain diets on energy metabolism (Kneeskern et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Influence of food deprivation on intravenous glucose tolerance test traits in Holstein Friesian heifers

González-Grajales

Pieper

Kremer

et al. 2017

Journal of Dairy Science

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Glucose is essential for numerous cellular functions due to its involvement in energy supply from early development to adulthood. In the lactating cow, glucose demands by the mammary gland significantly increase to support milk production when compared with other tissues. Thus, insufficient blood glucose levels might predispose dairy cows to metabolic disturbances. The intravenous glucose tolerance test (ivGTT) is a suitable tool to characterize glucose metabolism and insulin responses, but results must be reliable and repeatable. One factor influencing ivGTT is food deprivation period, which has been considered as an obligatory requirement before conduction of glucose tolerance studies in monogastric species, whereas it has been permissive in ruminants. The objective of this study was to determine the influence of 5 fasting periods (0, 12, 24, 36, and 48 h) on ivGTT traits and insulin responses in German Holstein heifers. A total of 140 tests were conducted in 28 females aged 12 to 19 mo. Blood samples were collected every 7 min within 1 h. Assessed glucose and insulin parameters included basal serum glucose and insulin concentration, maximum glucose and insulin concentration obtained between min 7 to 21, and concentrations at min 63 (last sampling) relative to glucose administration, glucose area equivalent (GA), glucose area under the curve (GAUC), insulin area equivalent (InsA), insulin area under the curve (InsAUC), and blood glucose half-life time (GHLT). Serum glucose and insulin concentration were measured according to the hexokinase colorimetric method and solid phase radio immunoassay, respectively. The generalized linear mixed model was used to test for significant differences in all glucose traits and insulin responses at different fasting periods. The model used season and weight as confounding variables. Glucose and insulin concentrations at 0, 7 to 21 (maximum concentration), and 63 min were affected by the duration of food deprivation. The GA, InsA, GAUC, InsAUC, and especially GHLT were also affected by fasting period. A positive linear relationship between GHLT and length of food deprivation was found. Significantly higher GA, GAUC, GHLT values, and glucose and insulin concentration at min 63 were obtained at increasing fasting periods. High intraclass correlation coefficient (0.48) was found for GHLT. The results demonstrate that GHLT might be used to reliably characterize an individual's glucose metabolism and the importance of standardizing food deprivation schedules when performing an ivGTT in nongestating Holstein heifers.

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Effect of Parenteral Antioxidant Supplementation During the Dry Period on Postpartum Glucose Tolerance in Dairy Cows

Cited by 39 publications

References 41 publications

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

A Summary of New Findings on the Biological Effects of Selenium in Selected Animal Species—A Critical Review

Effects of close-up body condition score and selenium-vitamin E injection on lactation performance, blood metabolites, and oxidative status in high-producing dairy cows

Influence of food deprivation on intravenous glucose tolerance test traits in Holstein Friesian heifers

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