Effect of Parenteral Selenium Administration to Sheep on Prevalence and Recovery from Footrot

Hall, Jean A.; Bailey, Daniel; Thonstad, K.N.; Saun, Robert J. Van

doi:10.1111/j.1939-1676.2008.0253.x

Cited by 13 publications

(15 citation statements)

References 26 publications

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“…Selenium is an essential element in ruminant's diet which provides a significant source of antioxidant defence and plays an important role in optimising both the immune response and disease resistance (Spears and Weiss, 2008). Indeed, it has been demonstrated that footrot affected sheep have lower blood selenium concentration and that selenium supplementation resulted in a more rapid improvement of foot lesions (Hall et al, 2009). Albumin is a free radical scavenger but it is also the predominant oxidised protein contributing to AOPP formation (Celi, 2011b).…”

Section: Discussionmentioning

confidence: 98%

“…Selenium is an essential element in the diet of animals and is important in host antioxidant defense (Rivera et al, 2005). Recently, it has been shown that whole-blood selenium is decreased in footrot-affected sheep and that parenteral selenium supplementation accelerates recovery from footrot (Hall et al, 2009). Therefore, it seems that footrot could induce oxidative stress, leading to increase in formation of free radicals.…”

Section: Introductionmentioning

confidence: 98%

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The use of digital infrared thermography and measurement of oxidative stress biomarkers as tools to diagnose foot lesions in sheep

Talukder

Gabai

Celi

2015

Small Ruminant Research

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

The use of digital infrared thermography and measurement of oxidative stress biomarkers as tools to diagnose foot lesions in sheep

Talukder

Gabai

Celi

2015

Small Ruminant Research

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“…The second pattern develops after birth in lambs within 3-6 weeks of birth but may occur as late as 4 months after birth [5]. The importance and roles of Se, selenoproteins, and vit E in muscle function and other veterinary important viewpoints were presented [5][6][7][8][9]. However, beneficial effects of nutritional or parenteral administration of vit E and Se have not been universal among studies [10][11][12].…”

Section: Introductionmentioning

confidence: 98%

Parenteral Selenium and Vitamin E Supplementation to Lambs: Hematology, Serum Biochemistry, Performance, and Relationship with Other Trace Elements

Mohri

Ehsani

Norouzian

et al. 2010

Biol Trace Elem Res

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Most regions in Iran are generally selenium (Se) deficient and all mineral premixes which used in farm animals contain Se in the form of sodium selenite. The objective of this study was to evaluate the effects of injected Se and vitamin E (vit E) on hematology, serum proteins, and performance of lambs during the period which the animals are at risk of Se and/or vit E deficiency. The study also aims to determine the relationship between selenium injection and the levels of other trace elements in blood serum of lambs. A total of 16 lambs of Baloochi breed (age, 70 ± 7 days and weight, 15.2 ± 1.4) were enrolled in the study. The animals were divided into two groups. In the test group, vit E and Se injected at a dose of 0.2 ml/kg BW (Vetoquinol, Selepherol®, Lure Cedex, France, α-tocopherol acetate 3.82 g/100 ml plus sodium selenite 0.023 g/100 ml) at the enrollment. Control lambs were received equal amounts of normal saline as placebo. Blood was sampled from the jugular vein at the beginning of the study (enrollment, before injection of vit E and selenium and saline) and at days 7, 14, 21, and 28 of experiment. The amounts of total serum protein, albumin, glucose, iron, copper, zinc, creatine kinase (CK), and aspartate aminotransferase (AST) and Se were measured. The concentration of globulin was calculated as the difference between total serum protein and albumin. For evaluation of growth and health, body weight of all the lambs was measured at day 0 of the experiment and the sampling times and days of treatment for each lamb were recorded. Treatment with Se and vit E decreased the activities of CK and AST compared to the controls (p < 0.05). Age (sampling time) had significant effects on the values of Se, iron, zinc, AST, hemoglobin, total protein, glucose, weight, height, and length (p < 0.05). Significant interactions between sampling time and group were seen for CK, AST, iron, glucose, weight, and length. No significant differences were seen for total weight gain (control, 3.48 ± 0.75 kg; test, 3.85 ± 0.9 kg), and average daily gain (control, 0.12 ± 0.03 kg; test, 0.14 ± 0.03 kg) between trial groups.

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“…We reported previously that FR-affected sheep have lower whole-blood selenium (WB-Se) concentrations and that parenteral Se-supplementation in conjunction with routine control practices accelerates recovery from FR [12]. As a follow-up, we examined in this study the mechanisms by which Se may facilitate recovery from FR.…”

Section: Introductionmentioning

confidence: 99%

Higher whole-blood selenium is associated with improved immune responses in footrot-affected sheep

Hall

Sendek

Chinn

et al. 2011

Vet Res

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We reported previously that sheep affected with footrot (FR) have lower whole-blood selenium (WB-Se) concentrations and that parenteral Se-supplementation in conjunction with routine control practices accelerates recovery from FR. The purpose of this follow-up study was to investigate the mechanisms by which Se facilitates recovery from FR. Sheep affected with FR (n = 38) were injected monthly for 15 months with either 5 mg Se (FR-Se) or saline (FR-Sal), whereas 19 healthy sheep received no treatment. Adaptive immune function was evaluated after 3 months of Se supplementation by immunizing all sheep with a novel protein, keyhole limpet hemocyanin (KLH). The antibody titer and delayed-type hypersensitivity (DTH) skin test to KLH were used to assess humoral immunity and cell-mediated immunity, respectively. Innate immunity was evaluated after 3 months of Se supplementation by measuring intradermal responses to histamine 30 min after injection compared to KLH and saline, and after 15 months of Se supplementation by isolating neutrophils and measuring their bacterial killing ability and relative abundance of mRNA for genes associated with neutrophil migration. Compared to healthy sheep, immune responses to a novel protein were suppressed in FR-affected sheep with smaller decreases in FR-affected sheep that received Se or had WB-Se concentrations above 250 ng/mL at the time of the immune assays. Neutrophil function was suppressed in FR-affected sheep, but was not changed by Se supplementation or WB-Se status. Sheep FR is associated with depressed immune responses to a novel protein, which may be partly restored by improving WB-Se status (> 250 ng/mL).

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Effect of Parenteral Selenium Administration to Sheep on Prevalence and Recovery from Footrot

Cited by 13 publications

References 26 publications

The use of digital infrared thermography and measurement of oxidative stress biomarkers as tools to diagnose foot lesions in sheep

The use of digital infrared thermography and measurement of oxidative stress biomarkers as tools to diagnose foot lesions in sheep

Parenteral Selenium and Vitamin E Supplementation to Lambs: Hematology, Serum Biochemistry, Performance, and Relationship with Other Trace Elements

Higher whole-blood selenium is associated with improved immune responses in footrot-affected sheep

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