Effect of Parquetina nigrescens (Afzel.) Leaves on Letrozole-Induced PCOS in Rats: a Molecular Insight into Its Phytoconstituents

Femi-Olabisi, Joy Fehintoluwa; Ishola, Ahmed Adebayo; Olujimi, Folakemi Omolara

doi:10.1007/s12010-023-04537-3

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…for female fertility and menstruation. [16][17][18] Natural products like pheoniflorin, catechins, licorice, and isosorbol have been shown in numerous scientific investigations to be promising as an alternate treatment for PCOS. [19][20][21][22][23][24][25][26] Treatment of syndromes with signs and symptoms linked to one another and with a disease is one area of medical practice where doctors frequently encounter difficulty.…”

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confidence: 99%

Evaluation of the anti‐PCOS Potential of Ethanolic Extract of Ocimum Gratissimum (Linn.) Leaf in Letrozole‐Induced Polycystic Ovarian Syndrome in Wistar Rats

Joy,

Adebayo,

Ola

et al. 2024

ChemistrySelect

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This study investigated the effect of ethanolic extract of Ocimum gratissimum leaves (EEOGL) on letrozole‐induced polycystic ovarian syndrome (PCOS) and determine the possible binding effects of compounds identified in EEOGL using molecular docking method. After the induction using letrozole (1 mg/kg), normal (n=4) and PCOS (n=16; 4 groups of 4 animals/group) were treated for 14 days orally with distilled water (1 ml/kg), metformin (500 mg/kg), clomiphene‐citrate (2 mg/kg), and EEOGL (50 and 100 mg/kg). 47 compounds were docked to androgen receptor (AR), estrogen receptor (ER), fructose‐1,6‐bisphosphate (FBP), and phosphoenolpyruvate‐carboxykinase (PEPCK) using Vina. The result obtained revealed that letrozole‐induced PCOS rats exhibited altered oestrous cycle and administration of the EEOGL at 50 mg/kg significantly (p<0.05) decreased the serum insulin, testosterone, luteinizing hormone (LH), Low Density Lipoprotein (LDL), total cholesterol (TC), triglyceride while serum concentration of Follicle stimulating hormone (FSH), estradiol, and High‐Density Lipoprotein (HDL) were significantly (p<0.05) increased compared to the control. However, administration of 100 mg/kg of the EEOGL did not reverse elevated insulin and LH levels. Molecular docking revealed four compounds with at high binding affinity for at least one of the proteins studied compared to standard drugs. Ethanolic extracts of O. gratissimum has the potential to regulate the reproductive‐induced alterations in PCOS rats.

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