Effect of partial denervation on motor units in the ageing rat medial gastronemius

Einsiedel, L.J.; Luff, A. R.

doi:10.1016/0022-510x(92)90148-e

Cited by 42 publications

(26 citation statements)

References 28 publications

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“…Maximal tension in adult and old rats was obtained at 150 Hz compared to 200 Hz in young animals. With increasing frequency of stimulation from 200 to 300 Hz we observed an increased occurrence of tetanic fade 7,22,23 in control muscle of adult and old rats (Figs. 3 and 4).…”

Section: Mainmentioning

confidence: 79%

“…Force for the 250-ms contraction time was determined for each contraction, and an average obtained for the four contractions. The extent of tetanic fade at 300 Hz was quantified by calculating a ''vulnerability index'' defined as the ratio of the force developed at the end of the 250-ms stimulation period to the peak force 7 ( Fig. 5A).…”

Section: Methodsmentioning

confidence: 99%

“…Decreases in axoplasmic transport, 3 speed of nerve regeneration, 17 and collateral sprouting to reinnervate denervated muscle fibers 7 are observed in old rats. Whole motor units are presumed to be lost in aged rats, 18 with corresponding decreases in the number of muscle fibers 2 and the overall mass of the muscle.…”

Section: Accepted 1 February 1998mentioning

confidence: 96%

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The force-frequency relationship is altered in regenerating and senescent rat skeletal muscle

Marsh¹,

Hinds²,

Lester³

et al. 1998

Muscle Nerve

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Section: Mainmentioning

confidence: 79%

Section: Methodsmentioning

confidence: 99%

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The force-frequency relationship is altered in regenerating and senescent rat skeletal muscle

Marsh¹,

Hinds²,

Lester³

et al. 1998

Muscle Nerve

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“…Several groups have reported skeletal muscle denervation and re-innervation, motor unit remodelling or loss in aging rodents or humans (Hashizume et al ., 1988;Kanda & Hashizume, 1989, 1992Einsiedel & Luff, 1992;Doherty et al ., 1993;Johnson et al ., 1995;Zhang et al ., 1996). Motor unit remodelling leads to changes in fibre-type composition (Pette & Staron, 2001).…”

Section: Neural Influences On Aging Skeletal Musclementioning

confidence: 99%

Neural control of aging skeletal muscle

2003

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SummaryFunctional and structural decline in the neuromuscular system with aging has been recognized as a cause of impairment in physical performance and loss of independence in the elderly. Alterations in spinal cord motor neurones and at the neuromuscular junction have been identified as evidence of denervation in skeletal muscles from aging mammals, including humans. However, the reciprocal influences of neurones on gene expression in muscle and of muscle on age-related neurodegeneration are poorly understood, and, as a result, interventions aimed at delaying or preventing degeneration of the neural component in aging muscle have been largely unsuccessful. The present article discusses the evidence for neural influence on age-related impairments of skeletal muscle, including a role in excitation-contraction uncoupling. The role of nerves in regulating the trophic actions of insulin-like growth factor-1 (IGF-1) and other neurotrophic factors is considered as a novel influence on the effects of aging on the neuromuscular junction. A better understanding of nerve-muscle interactions will allow for more rational interventions in the aging neuromuscular system.

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“…Studies to determine whether the age-related loss of muscle fibers is associated with loss of motor units in man and rodents indicate that substantial net loss of whole motor units occurs with increasing age in both species (28). Data indicate that in both species, net motor neuron loss occurs in parallel with muscle fiber loss and loss of muscle function (29), but it is unclear which of these is the primary event (14,28,52).…”

Section: Aging Is Associated With Loss Of Whole Motor Unitsmentioning

confidence: 99%

Interactions Between Reactive Oxygen Species Generated by Contractile Activity and Aging in Skeletal Muscle?

Jackson

2013

Antioxidants & Redox Signaling

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Significance: Aging leads to a loss of skeletal muscle mass and function that causes instability, increased risk of falls, and need for residential care. This is due to a reduction in the muscle mass and strength that is primarily due caused by a decrease in the number of muscle fibers, particularly, type II fibers, and atrophy and weakening of those remaining. Recent Advances: Although increased oxidative damage was originally thought to be the key to the aging process, data now indicate that reactive oxygen species (ROS) may be one of the several components of the degenerative processes in aging. The skeletal muscle shows important rapid adaptations to the ROS generated by contractions that are attenuated in aged organisms and transgenic studies have indicated that overcoming these attenuated responses can prevent the age-related loss of muscle mass and function. Critical Issues: Elucidation of the mechanisms by which the skeletal muscle adapts to the ROS generated to contractions and the way in which these processes are attenuated by aging is critical to the development of logical approaches to prevent age-related loss of muscle mass and function. Future Directions: Future studies are likely to focus on the redox regulation of adaptive pathways and their maintenance during aging as an approach to maintain and improve muscle function. Antioxid. Redox Signal. 19, 804-812.

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Effect of partial denervation on motor units in the ageing rat medial gastronemius

Cited by 42 publications

References 28 publications

The force-frequency relationship is altered in regenerating and senescent rat skeletal muscle

The force-frequency relationship is altered in regenerating and senescent rat skeletal muscle

Neural control of aging skeletal muscle

Interactions Between Reactive Oxygen Species Generated by Contractile Activity and Aging in Skeletal Muscle?

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