Effect of particle size and diluent type on critical parameters for disintegration of tablets containing croscarmellose sodium as a disintegrant

Tonglairoum, Prasopchai; Ngawhirunpat, Tanasait; Akkaramongkolporn, Prasert; Opanasopit, Praneet; Nattapulwat, Nattawat

doi:10.4314/tjpr.v16i6.2

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…The objective is to disperse the amiodarone in water in order to integrate it into a compote or the content of a baby bottle. It has been observed by Patrojanasophon et al that the size of the particles present in tablets can influence the disintegration time [72]. This is why the disintegration time will be tested as a function of the D-Sorbitol incorporated in the formulations.…”

Section: Three-dimensional Printing Of Fast Disaggregation Oral Formsmentioning

confidence: 99%

D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

et al. 2021

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Fused filament fabrication (FFF) is a process used to manufacture oral forms adapted to the needs of patients. Polyethylene oxide (PEO) filaments were produced by hot melt extrusion (HME) to obtain a filament suitable for the production of amiodarone hydrochloride oral forms by FFF 3D printing. In order to produce personalized oral forms adapted to the patient characteristics, filaments used by FFF must be controlled in terms of mass homogeneity along filament. This work highlights the relation between filament mass homogeneity and its diameter. This is why the impact of filler excipients physical properties was studied. It has been showed that the particle’s size distribution of the filler can modify the filament diameter variability which has had an impact on the mass of oral forms produced by FFF. Through this work it was shown that D-Sorbitol from Carlo Erba allows to obtain a diameter variability of less than 2% due to its unique particle’s size distribution. Using the filament produced by HME and an innovating calibration method based on the filament length, it has been possible to carry out three dosages of 125 mg, 750 mg and 1000 mg by 3D printing with acceptable mass uniformity.

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Section: Three-dimensional Printing Of Fast Disaggregation Oral Formsmentioning

confidence: 99%

D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

et al. 2021

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“…This occurred even though other studies have found an increase in the disintegration time of the tablets after exceeding a threshold proportion of 2 % CC for CP tablets. This threshold was attributed to the fact that increasing the amount of CC in the formulation also increased the hardness of the tablets [21]. In the same way, it was observed that increasing concentrations of the disintegrant Starch 1500 increased the percentage of Norfloxacin dissolved after 30 min, until a maximum is reached at about 12% Starch 1500.…”

Section: Effect Of the Excipients On The Disintegration Profile Of Ib...mentioning

confidence: 80%

Effect of Components and Deposition on Technological Performance of Ibuprofen Tablets

Velasco¹,

Robles²

2018

Int J App Pharm

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Objective: This work evaluated the influence of the technological properties of polyvinylpyrrolidone (PVP), calcium phosphate (CP) and cross-linked sodium carboxymethylcellulose (CC) as well as the deposition of a solid dispersion, through the solvent evaporation method, on the technological parameters that define the properties of ibuprofen tablets. Methods: The powder flow rate through an orifice, bulk volume and tapped volume of powders, tablet hardness, disintegration time and dissolution profile of the tablets were determined on individual components, their physical mixtures, granules obtained by deposition and solvent evaporation, and tablets obtained at different compaction pressures. Results: The very poor flowability of CP and the high compactibility of PVP were transferred to the powder mixtures, which showed poor flowability, and ibuprofen tablets with twice the compactibility. The tablets disintegration was high with a low proportion of CC (0.5%), but decreased linearly by increasing the proportion of the disintegrant up to 10%. At the same time, the dissolution of the drug after 30 min increased from 3% to 80%. The agglomeration of CP through the deposition of an alcoholic solution of the drug and PVP improved the flow properties and tripled the hardness of the tablets. However, the dissolution after 30 min decreased from 80% to 18%. Conclusion: The physical mixture was the best option to improve the dissolution, while the deposition on an adsorbent, of a solid dispersion of drug-PVP, was the best option to improve the compactibility and flow properties.

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“…The solubility depends on the chemical composition and physical form of the APIs (Active Pharmaceutical Ingredients). The rate at which drugs soluble in the biological fluids of the body is affected by the disintegration of the tablet 2 .…”

Section: Introductionmentioning

confidence: 99%

Immediate-release dosage form; focus on disintegrants use as a promising excipient

Kute,

Patil,

Kute

et al. 2023

J. Drug Delivery Ther.

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Disintegrants are materials or mixtures of substances added in the drug formulations, which make easier dispersion or breakup of tablets and ingredients of capsules in small-scale particles for fast dissolution then it comes in contact with water in the GI tract. Immediate drug release dosage forms disintegrate rapidly after administration with an enhanced rate of dissolution. The superdisintegrants provide instantaneous disintegration of tablets after administration in the stomach. In this field, immediate-release liquid dosage forms and parenteral dosage forms have also been introduced for treating patients. The oral route is the most convenient route for the administration of solid dosage form, about 85% of solid dosage is administered by the oral route because of its advantages over others. The therapeutic activity of these formulations is obtained through a typical manner like disintegration followed by dissolution. Hence disintegration has a major role in facilitating drug activity. Diverse categories of superdisintegrants such as synthetic, semi-synthetic, natural, co-processed blends, multifunctional superdisintegrants, etc. have been employed to develop effectual orodispersible tablets and to overcome the limitations of conventional tablet dosage forms. The objective of the present review article is to highlight the various kinds of traditional, Natural crude drugs containing gum and mucilage, Co-processed, semisynthetic and synthetic disintegrants along with a concentration in tablet and capsule disintegration and effect on drug release, which are being used in the formulation to provide the safer, effective drug delivery with patient compliance. Also highlights the mechanism and use of disintegrants in the immediate release dosage form. Keywords: Disintegrants, Natural, Co-processed, Immediate release

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Effect of particle size and diluent type on critical parameters for disintegration of tablets containing croscarmellose sodium as a disintegrant

Cited by 4 publications

References 15 publications

D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

D-Sorbitol Physical Properties Effects on Filaments Used by 3D Printing Process for Personalized Medicine

Effect of Components and Deposition on Technological Performance of Ibuprofen Tablets

Immediate-release dosage form; focus on disintegrants use as a promising excipient

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