Effect of Particle Size, Composition, and Thermal Treatment on the Crystalline Structure of Polycaprolactone Nanoparticles

Cho, Eun Chul; Cho, Kilwon; Ahn, Jong Kun; Kim, Junoh; Chang, Ih-Seop

doi:10.1021/bm050883s

Cited by 16 publications

(26 citation statements)

References 24 publications

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“…The increasing trend of the mean micelle size with the increase in the homopolymer content is consistent with recent relevant experimental observations. 10,12,13 Furthermore, with the increase of H , the peak value of the H-block density φ H increases (Figure 3b), whereas those of Aand B-block density profiles decrease (Figure 3c,d). This can be easily understood by considering the relative change of the number of homopolymer and diblock copolymer molecules under the condition that their total number is constant in all the simulations.…”

Section: Resultsmentioning

confidence: 93%

“…Different structures of drug delivery vehicles exhibit different ability in drug encapsulation efficiency, drug release rate, and cellular uptake efficiency. [8][9][10][11][12][15][16][17][18][19] This study is helpful for optimal design of novel drug delivery vehicles with controlled shape and size, which have promising applications in the field of nanomedicine.…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10][11][12] Controlling the shape and size of nanostructures is a fundamental and crucial issue in the design of nanosized drug delivery vehicles. Therefore, much effort has also been directed toward studying internal structures composed of amphiphilic block copolymers.…”

Section: Introductionmentioning

confidence: 99%

“…In the case that a diblock copolymer self-assembles into rodlike micelles or vesicles, the addition of a homopolymer can also modulate their morphologies. 13,14 Besides the stoichiometry of polymers, the composition of copolymers is another important factor that influences not only the particle size 12,[15][16][17][18][19] but also the drug encapsulation efficiency, drug release rate, and cellular uptake. [15][16][17][18][19] For amphiphilic block copolymer micelles, in general, a higher fraction of hydrophobic chain will raise the micelle size.…”

Section: Introductionmentioning

confidence: 99%

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Self-Assembled Nanostructures of Homopolymer and Diblock Copolymer Blends in a Selective Solvent

Feng

2010

J. Phys. Chem. B

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Self-assembled nanostructures of amphiphilic block copolymers hold great promise for applications in nanomedicine. Blending polymers provides an effective way to produce multifunctional drug delivery vesicles at micro- and nanoscales. Here we investigate the self-assembly of homopolymer and diblock copolymer blends in a selective solvent by using the self-consistent field method. It is found that self-assembled nanostructures of different sizes and shapes (e.g., vesicles, circle- and line-like micelles, and their mixtures) can be obtained by varying the concentration and composition of the diblock copolymer. As the chain length or concentration of the homopolymer changes, morphological transitions may occur among the different nanostructures. On the basis of a number of simulations under various conditions, a phase diagram of aggregate morphologies is constructed with respect to the mixture ratio and the homopolymer chain length. The theoretical method presented here could be used to design novel nanomedicine carriers and to optimize their sizes and shapes for specific biomedical applications.

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Section: Resultsmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Self-Assembled Nanostructures of Homopolymer and Diblock Copolymer Blends in a Selective Solvent

Feng

2010

J. Phys. Chem. B

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“…4c; 111 nm based on PCS) [28]. The images showed dots characteristic of solid nanoparticles and micelles [29] between 50 and 70 nm in diameter. This is different from the structure of vesicles (Figs.…”

Section: Effect Of the P(maac-co-sma30)-26k Concentration On The Strumentioning

confidence: 99%

Effect of polymer characteristics on structure of polymer–liposome complexes

Cho

Lim

Shim

et al. 2007

Journal of Colloid and Interface Science

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Evaluation of electron beam‐induced crosslinking of poly(ε‐caprolactone)—Effect of elevated temperatures

Huang

Gohs²,

Müller

et al. 2019

J of Applied Polymer Sci

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The effect of elevated temperatures (40, 80, and 170 °C) on the electron beam (EB)‐induced crosslinking and degradation of poly(ε‐caprolactone) (PCL) in nitrogen atmosphere without adding crosslinking agents has been investigated. The increased mass average molecular mass of EB modified masticated PCL (mPCL) samples were measured by size exclusion chromatography. The sol–gel investigation showed that mPCL tended to dominating crosslinking at a temperature of 170 °C. At this temperature, the maximum gel content of 56% was observed for an EB treatment with a dose of 100 kGy. In addition, the ratio of chain scission density to density of crosslinked units amounted to 0.25. The dynamic rheological test demonstrated that EB treatment at 170 °C led to the most remarkable elasticity enhancement behavior with enhanced viscosity, modulus, and decreased loss factor (tan δ). The occurrence of branching structure was evidently detected by van Gurp–Palmen plot in combination with the Cole–Cole plot for dose values ≤50 kGy. Less δ and a broadened relaxation process can be observed due to the introduction of some branched structures into mPCL. The results of enhanced molar mass and gel content analysis were confirmed by the dynamic rheological measurements. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47866.

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Effect of Particle Size, Composition, and Thermal Treatment on the Crystalline Structure of Polycaprolactone Nanoparticles

Cited by 16 publications

References 24 publications

Self-Assembled Nanostructures of Homopolymer and Diblock Copolymer Blends in a Selective Solvent

Self-Assembled Nanostructures of Homopolymer and Diblock Copolymer Blends in a Selective Solvent

Effect of polymer characteristics on structure of polymer–liposome complexes

Evaluation of electron beam‐induced crosslinking of poly(ε‐caprolactone)—Effect of elevated temperatures

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