Effect of Particle Size of Nano-Oxides on Color Stability and Mechanical Properties of Maxillofacial Silicone Elastomers: An In Vitro Study

Mohan, Ashika S; Manju, .; Babu, Anna Serene; Krishnapriya, V

doi:10.11607/ijp.6593

Cited by 5 publications

(6 citation statements)

References 9 publications

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“…This may be attributed to the fact that CeO 2 /BSA nanoclusters in the 0.8 BSA group had a smaller size of 2 nm. This affected the chemical and biological properties of CeO 2 /BSA nanoclusters, which is consistent with previous studies. , Therefore, the synthesis ratio of CeO 2 /BSA nanoclusters in the 0.8 group was used in the following experiments. Overall, we found that the CeO 2 /BSA nanoclusters had excellent ROS-scavenging ability in a concentration-dependent manner (Figure i–k).…”

Section: Resultssupporting

confidence: 87%

“…This affected the chemical and biological properties of CeO 2 /BSA nanoclusters, which is consistent with previous studies. 21,22 Therefore, the synthesis ratio of CeO 2 /BSA nanoclusters in the 0.8 group was used in the following experiments. Overall, we found that the CeO 2 /BSA nanoclusters had excellent ROS-scavenging ability in a concen- We constructed a PH cell model using PMECs under hypoxic conditions.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

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CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

Zhao,

Wu,

et al. 2024

ACS Appl. Nano Mater.

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Endothelial dysfunction is one of the main pathogenetic mechanisms of pulmonary hypertension (PH). In the pathological microenvironment, excess reactive oxygen species (ROS) further induce pulmonary microvascular endothelial cell (PMEC) dysfunction. Recently, there has been an extreme lack of drugs that specifically target and eliminate ROS within the microenvironment. Although some nanomaterials are known as effective ROS-scavenging agents and can further alleviate disease progression, few nanomaterials have been reported in the endothelial dysfunction of PH. Based on the above situation, we synthesized a kind of novel nanoclusters (cerium dioxide/bovine serum albumin, CeO 2 /BSA), which can not only effectively scavenge ROS but also inhibit hypoxia-induced PMEC overproliferation, migration, and apoptosis resistance. CeO 2 /BSA nanoclusters were proved to be enriched in the lung, which effectively relieved pulmonary vascular remodeling, reduced the pressure of the pulmonary artery, and finally significantly improved cardiac function. Through in-depth mechanism analysis, we found that CeO 2 /BSA nanoclusters may be involved in Th1 and Th2 differentiation pathways mainly by effectively scavenging high levels of ROS in the pulmonary artery. In addition, the good biocompatibility of CeO 2 /BSA nanoclusters increased the possibility of their clinical application in the treatment of PH. In conclusion, this work provides a novel and effective solution to improve the dilemma of the ROS target and elimination in the treatment of PH.

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Section: Resultssupporting

confidence: 87%

Section: ■ Experimental Sectionmentioning

confidence: 99%

CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

Zhao,

Wu,

et al. 2024

ACS Appl. Nano Mater.

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“…The increase in tear strength values after aging is consistent with the results of some studies of Nobrega et al [ 21 ], Fatalla et al [ 22 ] and Bates et al [ 23 ]; and not in alignment with others [ 13 , 14 , 16 , 25 ]. Reason for such contrasting result can be attributed to difference in the silicone elastomer used, fillers used, and the method and duration of aging.…”

Section: Discussionsupporting

confidence: 91%

“…The hardness values of TiO 2 and PTFE incorporated groups was found to be significantly higher than that of the control group both before; (TiO 2 : P = 0.000; PTFE: P = 0.001) and after weathering (TiO 2 P = 0.000; PTFE: P = 0.000). This result is similar with the results of studies conducted by Abdul-Ameer [ 8 ], Abdelfattah et al [ 10 ], Shaqir and Abdul-ameer [ 11 ], Park [ 16 ], Radey et al [ 20 ], and Mohan et al [ 25 ]. This increase in hardness can be attributed to the structural changes brought by the incorporated nanoparticles in the silicone elastomer such as increased cross-linking density by TiO 2 nanoparticles and formation of nodes and fibres by PTFE nanoparticles [ 11 , 16 ].…”

Section: Discussionsupporting

confidence: 91%

Effect of Organic and Inorganic Nanoparticles on Colour Stability and Mechanical Properties of Heat Vulcanised Maxillofacial Silicone Elastomer: a Comparative Study

Khanna,

Sehgal,

Singla

et al. 2024

JOMR

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Objectives The purpose of this comparative study in vitro was to evaluate the effect of organic and inorganic nanoparticles on colour stability, tear strength and hardness of maxillofacial silicone elastomer at baseline and when subjected to outdoor weathering for 6 months. Material and Methods A total of 240 specimens were fabricated using M511 platinum silicone which were divided into total 4 groups (n = 60) based on the type of nanoparticles (control, polytetrafuoroethylene [PTFE], titanium dioxide [TiO 2 ], zinc oxide [ZnO]) added and each group was further divided into 3 subgroups (n = 20) for colour, tear strength (TS) and hardness (H) testing. The tests were conducted and data was obtained both before and after outdoor weathering of 6 months. Results Minimum colour change after weathering was observed in PTFE group (∆E = 2.23). TiO 2 group showed maximum TS (12.01 N/mm) followed by PTFE group (10.85 N/mm) before weathering. After weathering, maximum TS was shown by TiO 2 group (12.9 N/mm) and PTFE group (12.54 N/mm). TiO 2 group showed maximum hardness (24.15 shore A) before weathering and PTFE group showed maximum hardness (33.43 shore A) after weathering. Conclusions Within the limitations of this study, it can be concluded that the addition of polytetrafuoroethylene nanoparticles to the polymer enhances both the optical as well as mechanical properties and can be considered favourable for the extended life of the prosthesis.

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“…Silicones showed increased roughness after either nonthermal plasma treatment (NTP TT) or accelerated aging. This indicates surface disintegration due to sorption and solubility over an extended period of use because of exposure to environmental influences, body fluids and secretions, and cleansing or disinfecting solutions, causing the material to harden and change color ( Table 1 ) [35] , [36] , [37] , [38] , [39] .…”

Section: Resultsmentioning

confidence: 99%

Frequently used extraoral maxillofacial prosthetic materials and their longevity – A comprehensive review

Annamma,

Hattori,

Ali

et al. 2024

Japanese Dental Science Review

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Effect of Particle Size of Nano-Oxides on Color Stability and Mechanical Properties of Maxillofacial Silicone Elastomers: An In Vitro Study

Cited by 5 publications

References 9 publications

CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

Effect of Organic and Inorganic Nanoparticles on Colour Stability and Mechanical Properties of Heat Vulcanised Maxillofacial Silicone Elastomer: a Comparative Study

Frequently used extraoral maxillofacial prosthetic materials and their longevity – A comprehensive review

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Effect of Particle Size of Nano-Oxides on Color Stability and Mechanical Properties of Maxillofacial Silicone Elastomers: An In Vitro Study

Cited by 5 publications

References 9 publications

CeO2/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

CeO2/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

Effect of Organic and Inorganic Nanoparticles on Colour Stability and Mechanical Properties of Heat Vulcanised Maxillofacial Silicone Elastomer: a Comparative Study

Frequently used extraoral maxillofacial prosthetic materials and their longevity – A comprehensive review

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CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension

CeO₂/Bovine Serum Albumin Nanoclusters with Robust Reactive Oxygen Species Scavenging and Improved Endothelial Dysfunction Abilities for the Treatment of Pulmonary Hypertension