Effect of particulate matter-bound metals exposure on prothrombotic biomarkers: A systematic review

Signorelli, Salvatore Santo; Conti, Gea Oliveri; Zanobetti, Antonella; Baccarelli, Andrea A.; Fiore, Maria

doi:10.1016/j.envres.2019.108573

Cited by 75 publications

(22 citation statements)

References 82 publications

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“…Air pollution has been identified as the largest environmental cause of disease and premature death in the world ( GBD, 2018 ). Ambient particulate matter (PM) induces its pro-inflammatory and thrombogenic effects through the generation of oxidative stress by its chemical compounds and metals ( Li et al, 2008 ; Signorelli et al, 2019 ). The recent identification of environmentally persistent free radicals (EPFRs) in the PM, resulting from a mixture of combustion sources, theorize its role in the increase of disease severity of lower respiratory tract infections (LRTI) ( Jaligama et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review

Copat

Cristaldi

Fiore

et al. 2020

Environmental Research

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328

240

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A new coronavirus (SARS-CoV-2) has determined a pneumonia outbreak in China (Wuhan, Hubei Province) in December 2019, called COVID-19 disease. In addition to the person-to person transmission dynamic of the novel respiratory virus, it has been recently studied the role of environmental factors in accelerate SARS-CoV-2 spread and its lethality. The time being, air pollution has been identified as the largest environmental cause of disease and premature death in the world. It affects body's immunity, making people more vulnerable to pathogens. The hypothesis that air pollution, resulting from a combination of factors such as meteorological data, level of industrialization as well as regional topography, can acts both as a carrier of the infection and as a worsening factor of the health impact of COVID-19 disease, has been raised recently. With this review, we want to provide an update state of art relating the role of air pollution, in particular PM 2.5 , PM 10 and NO 2 , in COVID-19 spread and lethality. The Authors, who first investigated this association, often used different research methods or not all include confounding factors whenever possible. In addition, to date incidence data are underestimated in all countries and to a lesser extent also mortality data. For this reason, the cases included in the reviewed studies cannot be considered conclusive. Although it determines important limitations for direct comparison of results, and more studies are needed to strengthen scientific evidences and support firm conclusions, major findings are consistent, highlighting the important contribution of PM 2.5 and NO 2 as triggering of the COVID-19 spread and lethality, and with a less extent also PM 10 , although the potential effect of airborne virus exposure it has not been still demonstrated.

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Section: Introductionmentioning

confidence: 99%

The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review

Copat

Cristaldi

Fiore

et al. 2020

Environmental Research

Self Cite

328

240

View full text Add to dashboard Cite

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“…MDA is one of the products of lipid peroxidation and is considered as a marker of damage caused by free radicals, and its increase is a sign of free radical accumulation and oxidative damage [34][35][36].There is evidence that the components of cement dust such as Cr, silica and Al can cause overproduction of free radicals and oxidative stress [37][38][39]. Other studies have also shown that cement dust increases level of MDA [12,40,41], and some studies have reported that exposure to noise more than the threshold limit leads to increase in MDA levels in plasma and increased oxidative stress [21,42,43].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Oxidative Stress and Biochemical Biomarkers, and Psychological Parameters in Cement Plant Workers

Darabi¹,

Keshavarzi²,

Abdullah³

et al. 2020

Preprint

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BackgroundThe cement industry is one of the main world industries with exposure to a wide range of hazardous chemical and physical occupational agents that can increase free radicals and cause diseases. The aim of this study was to evaluate oxidative stress, and biochemical markers and psychological parameters among cement plant workers who were exposed to variety of hazardous occupational agents.MethodsIn this cross-sectional study 40 workers exposed to cement and 40 office employees, were selected as the exposed and control group, respectively. Exposure to cement dust, silica and noise were respectively assessed using the NIOSH 0600, NIOSH 7601 and noise dosimetry methods. Oxidative stress biomarkers including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAC), and biochemical parameters were measured in the serum of all participants. Depression, anxiety and stress were assessed by Depression Anxiety Stress Scales (DASS-21) questioner. Statistical analysis was performed by SPSS22 software. Independent t-test, Mann-Whitney U, Chi-square were used to evaluate the relation between variables. ResultsThe results demonstrated that the level of MDA as a marker of oxidative stress was significantly higher in the exposed group.Antioxidant enzymes including SOD and CAT were significantly higher, and TAC was insignificantly lower in the exposed group. Alkaline phosphatase (ALP), aspartate transaminase (AST), depression and stress were also significantly higher in the exposure group. It seems like working in cement plants, can have hazardous effects on liver function, enzyme activity and mental health.

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“…Metals in fine and ultrafine suspended particles have been associated with an increase in the risk of thrombosis; for example, Zhu et al (2020) reported that elevated concentrations of certain metals (iron (Fe), copper (Cu), zinc (Zn), cadmium (Cd), and antimony) increased the risk of atherosclerotic cardiovascular disease and thrombosis. Signorelli et al (2019) conclude in a systematic review that exposure to PM and inhalable metals can increase prothrombotic and platelet activation biomarkers. Furthermore, there are several studies that explore the toxic effects of metals on platelets that will later be discussed in this article.…”

Section: The Role Of Pm and Metals In Thrombosismentioning

confidence: 99%

A brief review of the biology of megakaryocytes and platelets and their role in thrombosis associated with particulate air pollution

et al. 2021

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Air pollution is a worldwide public health issue and it is associated with millions of premature deaths due to cancer, thrombosis, and pulmonary and cardiovascular diseases. Thrombosis is the excessive clotting that blocks a blood vessel, and its etiology is multifactorial. In recent years, growing evidence has linked air pollution, especially particulate matter (PM) and metals, to the development of thrombosis. PM and metals induce lung and systemic inflammation and oxidative stress that are frequent mechanisms in thrombosis. Platelets are important effectors of physiological hemostasis and pathological thrombosis. They are responsible for the formation of the initial plug and are important in the cellular model of coagulation. Therefore, any changes in their morphology or function or an increase in activation could be extremely relevant in thrombosis. Megakaryocytes (MKs) in the bone marrow and in the lungs are the precursor cells of platelets, and the latter is the first organ injured by air pollution. There is substantial evidence of the effect that PM and metals have on platelets, but there is almost no research about the effect of PM and metals on MKs. It is very likely that the alterations produced by air pollution originate in these cells. In this article, we review the biology of MKs and platelets and their role in particulate air pollution-related thrombosis to emphasize the need for further research in this field.

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Effect of particulate matter-bound metals exposure on prothrombotic biomarkers: A systematic review

Cited by 75 publications

References 82 publications

The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review

The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review

Evaluation of Oxidative Stress and Biochemical Biomarkers, and Psychological Parameters in Cement Plant Workers

A brief review of the biology of megakaryocytes and platelets and their role in thrombosis associated with particulate air pollution

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