Effect of Paternal Age on Reproductive Outcomes of Intracytoplasmic Sperm Injection

Wu, Yixuan; Kang, Xiangjin; Zheng, Haiyan; Liu, Haiying; Huang, Qing; Liu, Jianqiao

doi:10.1371/journal.pone.0149867

Cited by 40 publications

(41 citation statements)

References 21 publications

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“…However, paternal age did not seem to affect ART outcomes when ICSI and good quality oocytes were used [82] . APA negatively influenced the number of high-quality embryos but did not affect pregnancy outcomes in couples undergoing ICSI cycles [83] .…”

Section: Resultsmentioning

confidence: 88%

Lifestyle causes of male infertility

Durairajanayagam

2018

Arab Journal of Urology

280

176

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ObjectiveTo examine the potential effects of lifestyle factors on male reproductive health. Evidence of a global decline in human sperm quality over recent decades has been accumulating. Environmental, occupational, and modifiable lifestyle factors may contribute to this decline. This review focuses on key lifestyle factors that are associated with male infertility such as smoking cigarettes, alcohol intake, use of illicit drugs, obesity, psychological stress, advanced paternal age, dietary practices, and coffee consumption. Other factors such as testicular heat stress, intense cycling training, lack of sleep and exposure to electromagnetic radiation from mobile phone use are briefly discussed.Materials and methodA comprehensive literature search was performed to identify and synthesise all relevant information, mainly from within the last decade, on the major lifestyle factors associated with male infertility and semen quality. Database searches were limited to reports published in English only. A manual search of bibliographies of the reports retrieved was conducted to identify additional relevant articles.ResultsIn all, 1012 articles were identified from the database search and after reviewing the titles and abstract of the reports, 104 articles met the inclusion criteria. Of these, 30 reports were excluded as the full-text could not be retrieved and the abstract did not have relevant data. The remaining 74 reports were reviewed for data on association between a particular lifestyle factor and male infertility and were included in the present review.ConclusionThe major lifestyle factors discussed in the present review are amongst the multiple potential risk factors that could impair male fertility. However, their negative impact may well be mostly overcome by behaviour modification and better lifestyle choices. Greater awareness and recognition of the possible impact of these lifestyle factors are important amongst couples seeking conception.

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Section: Resultsmentioning

confidence: 88%

Lifestyle causes of male infertility

Durairajanayagam

2018

Arab Journal of Urology

280

176

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“…Nevertheless, above this age, sperm quality may compromise fertilization and affect IVF success rate though the practice of sperm freezing at a younger age will no doubt be getting further attention in the future (Wu, Lipshultz, & Kovac, ). In the other hand, a large European multicenter study showed that the risk of infertility is significantly increased in male patients older than 40, when the female partner age is over 39 years of age (De La Rochebrochard & Thonneau, ; Wu, Kang, et al, ).…”

Section: Discussionmentioning

confidence: 99%

Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years

Kaarouch

Bouamoud

Madkour

et al. 2018

Molecular Reproduction Devel

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This study assessed sperm quality declining on relation to paternal age and its impact on in vitro fertilization (IVF) outcomes in order to estimate the APA (Advanced Paternal Age) cutoff. For this, 83 couples undergoing IVF treatment for male factor infertility were enrolled. The women age was ≤39 years, whereas the men were divided in two groups: APA (n = 41; age ≥ 40 years) and young (Y) (n = 42; age < 40 years). Conventional semen parameters (volume, concentration, motility, vitality, and morphology) were analyzed in the collected sperm samples. Furthermore, sperm genome decays (SGD) was assessed by TUNEL assay (DNA fragmentation), aniline blue staining (chromatin decondensation), and fluorescent in situ hybridization (aneuploidy). No significant difference was found concerning the conventional semen parameters between APA and Y groups. Conversely, SGD analysis showed increased DNA fragmentation; chromatin decondensation and sperm aneuploidy rates in the APA group (respectively, 41%, 43%, and 14% vs. 25%, 23%, and 4% in Y group). IVF outcomes also were affected by paternal age as indicated by the rates of cancelled embryo transfers, clinical pregnancy and miscarriage in the two groups APA and Y (29%, 17%, and 60% vs. 10%, 32%, and 42%). Finally, statistical analysis of the results suggests that the age of 40 should be considered as the APA cutoff during ART attempts.

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“…The rate of ongoing pregnancy was only 1.3% with initial serum hCG level < 100 mIU/ml. We didn't analyze the impact of paternal age here because our previous study proved that paternal age had little effect on pregnancy outcomes [29].…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Outcomes of Patients with Low Serum β-hCG Level 14 Days After Fresh Embryo Transfer

Wu¹,

Liu²

2020

Preprint

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Background: Although previous studies had successfully illustrated different pregnancy outcomes by different serum β-hCG levels after embryo transfer, prognosis of pregnancy outcomes remains elusive when the serum β-hCG level is extremely low (e.g., < 100 mIU/ml 14 days after embryo transfer). Therefore, the purpose of our study is to investigate the pregnancy outcomes of patients with low serum β-hCG level 14 days after day 3 embryo transfer. Methods: A retrospective study was performed with 723 patients with a serum β-hCG level between 5 and 100 mIU/ml 14 days after day 3 fresh embryo transfer. Pregnancy outcomes (ongoing pregnancy, early miscarriage, biochemical pregnancy loss, and ectopic pregnancy) were analyzed according to the female patients’ age. Receiver operating characteristic (ROC) curves were plotted to indicate the threshold for prediction of clinical pregnancy and ongoing pregnancy. Sensitivity and specificity were calculated according the ROC curves as well. Results: Of the 723 patients with serum β-hCG level <100 mIU/mL 14 days after day 3 embryo transfer, 85.6% (619) had biochemical pregnancy, and only 14.4% (104) had clinical pregnancy (including 4.7% with ongoing pregnancy, 3.7% with ectopic pregnancy, and 5.9% with early miscarriage). The rate of ongoing pregnancy was significantly lower in ≥ 38-year group compared with < 38-year group (1.3% vs. 5.6%, P =0.029). The serum β-hCG level to predict clinical pregnancy was 44.7 mIU/ml (sensitivity, 91.3%; specificity, 82.1%; area under the ROC curve (AUROC), 0.908). For ongoing pregnancy, the serum β-hCG level was 53.7 mIU/ml (sensitivity, 94.1%; specificity, 81.4%; AUROC, 0.902). Conclusions: Initially low serum β-hCG level 14 days after day 3 embryo transfer indicated poor prognosis with minimal likelihood of ongoing pregnancy. Keywords: assisted reproductive technology; human chorionic gonadotropin; pregnancy; live birth; embryo transfer

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Effect of Paternal Age on Reproductive Outcomes of Intracytoplasmic Sperm Injection

Cited by 40 publications

References 21 publications

Lifestyle causes of male infertility

Lifestyle causes of male infertility

Paternal age: Negative impact on sperm genome decays and IVF outcomes after 40 years

Pregnancy Outcomes of Patients with Low Serum β-hCG Level 14 Days After Fresh Embryo Transfer

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