Fiber Bragg grating (FBG) sensor technology is expected to make an important contribution to extending the lifetime of polymer electrolyte membrane (PEM) fuel cells. It allows accurate measurements of insitu operating temperature and humidity, which is essential for an accurate control of both. For these applications an accurate and reliable calibration is crucial. This paper demonstrates the successful use of a 2x2 factorial calibration method for calibration of two standard FBGs for application in a PEM fuel cell. The calibrated low-cost FBG sensor allows temperature and humidity measurements with a RMS error (RMSE) of 0.45°C and 4.8 %RH, respectively.